BMC Research Notes | |
An unusual case of a large fibroepithelial stromal polyp presenting as a nipple mass | |
William Merchant1  EPL Turton2  Abeer M Shaaban1  | |
[1] Department of Histopathology and Molecular Pathology, St James’s University Hospital, Level 5 Bexley Wing, Leeds LS9 7TF, UK;Department of Breast and Endocrine Surgery, St James’s Hospital, Leeds, UK | |
关键词: Fibroepithelial polyp; Nipple; Breast; | |
Others : 1141795 DOI : 10.1186/1756-0500-6-345 |
|
received in 2013-01-31, accepted in 2013-08-29, 发布年份 2013 | |
【 摘 要 】
Background
Fibroepithelial stromal polyps (FESP) are benign lesions that typically occur in the genital area and are known to represent a diagnostic challenge for pathologists. Not only do they have a spectrum of morphological changes that ranges from bland morphology to rather atypical appearances, but they also share morphological features with a number of benign and malignant lesions.
This is a report of a rare presentation of a FESP of the breast.
Case presentation
We describe an unusual case of a large polypoid mass arising from the nipple and connected to it by a long pedicle in a female of 45. The lesion comprised spindle and stellate shaped cells with bizarre stromal giant cells. The morphological and immunohistochemical diagnostic features are provided together with a discussion of possible mimics.
Conclusion
FESPs may occur in the female breast. It is important to differentiate the lesion from other benign and malignant spindle cell lesions particularly metaplastic carcinoma.
【 授权许可】
2013 Shaaban et al.; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
20150327141744439.pdf | 1074KB | download | |
Figure 2. | 173KB | Image | download |
Figure 1. | 107KB | Image | download |
【 图 表 】
Figure 1.
Figure 2.
【 参考文献 】
- [1]Nowak MA, Marzich CS, Scheetz KL, McElroy JB: Benign fibroepithelial polyps of the renal pelvis. Arch Pathol Lab Med 1999, 123(9):850-852.
- [2]McCluggage WG: A review and update of morphologically bland vulvovaginal mesenchymal lesions. Int J Gynecol Pathol 2005, 24(1):26-38.
- [3]Ostor AG, Fortune DW, Riley CB: Fibroepithelial polyps with atypical stromal cells (pseudosarcoma botryoides) of vulva and vagina. A report of 13 cases. Int J Gynecol Pathol 1988, 7(4):351-360.
- [4]Nielsen GP, Young RH: Mesenchymal tumors and tumor-like lesions of the female genital tract: a selective review with emphasis on recently described entities. Int J Gynecol Pathol 2001, 20(2):105-127.
- [5]Belli AK, Somuncu E, Aydogan T, Bakkaloglu D, Ilvan S, Aydogan F: Fibroepithelial polyp of the nipple in a woman. Breast J 2013, 19(1):111-112.
- [6]Piubello Q, Parisi A, Eccher A, Barbazeni G, Franchini Z, Iannucci A: Flat epithelial atypia on core needle biopsy: which is the right management? Am J Surg Pathol 2009, 33(7):1078-1084.
- [7]Souza LB, Andrade ES, Miguel MC, Freitas RA, Pinto LP: Origin of stellate giant cells in oral fibrous lesions determined by immunohistochemical expression of vimentin, HHF-35, CD68 and factor XIIIa. Pathology 2004, 36(4):316-320.
- [8]Lucas EW Jr, Branton P, Mecklenburg FE, Moawad GN: Ectopic breast fibroadenoma of the vulva. Obstet Gynecol 2009, 114(2 Pt 2):460-462.
- [9]Kazakov DV, Spagnolo DV, Kacerovska D, Michal M: Lesions of anogenital mammary-like glands: an update. Adv Anat Pathol 2011, 18(1):1-28.
- [10]Brogi E: Benign and malignant spindle cell lesions of the breast. Semin Diagn Pathol 2004, 21(1):57-64.
- [11]El-Sayed ME, Rakha EA, Reed J, Lee AH, Evans AJ, Ellis IO: Predictive value of needle core biopsy diagnoses of lesions of uncertain malignant potential (B3) in abnormalities detected by mammographic screening. Histopathology 2008, 53(6):650-657.
- [12]Behtash N, Mousavi A, Tehranian A, Khanafshar N, Hanjani P: Embryonal rhabdomyosarcoma of the uterine cervix: case report and review of the literature. Gynecol Oncol 2003, 91(2):452-455.