Association between HLA genes and American cutaneous leishmaniasis in endemic regions of Southern Brazil

BMC Infectious Diseases

Thaís GV Silveira³  Sueli D Borelli¹  Maria VC Lonardoni³  Waldir V da Silva⁴  Maria CG dos Santos²  Adriana D Ribas²  Rejane C Ribas-Silva² 

[1] Immunogenetics Laboratory, Department of Basic Health Sciences, Universidade Estadual de Maringá (UEM), Maringá, Paraná, Av. Colombo, 5.790 - Jd. Universitário, 87020-900, Brazil;Postgraduate Program in Health Science, Universidade Estadual de Maringá (UEM), Maringá, Paraná, Av. Colombo, 5.790 - Jd. Universitário, 87020-900, Brazil;Leishmaniases Laboratory, Department of Clinical Analyses and Biomedicine, Universidade Estadual de Maringá (UEM), Maringá, Paraná, Av. Colombo, 5.790 - Jd. Universitário, 87020-900, Brazil;Department of Biostatistics, Universidade Estadual de Maringá (UEM), Maringá, Paraná, Av. Colombo, 5.790 - Jd. Universitário, 87020-900, Brazil

关键词: Leishmania brasiliensis;    Leishmaniasis;    HLA;    Genetic susceptibility;   

Others  :  1148616
DOI  :  10.1186/1471-2334-13-198

 received in 2012-08-17, accepted in 2013-04-18,  发布年份 2013

【 摘 要 】

Background

The present study sought to investigate the association between HLA-A, HLA-B and HLA-DRB1 genes and susceptibility or resistance to the different clinical manifestations of American cutaneous leishmaniasis (ACL) in southern Brazil.

Methods

The sample consisted of 169 patients with a diagnosis of ACL and 270 healthy subjects for comparison. HLA-A, HLA-B and HLA-DRB1 were typed by PCR-SSO reverse dot blot.

Results

Results showed a trend towards susceptibility to cutaneous lesions for alleles HLA-DRB1*13 (P=0.0228; Pc=0.3420; OR=1.66; 95%CI=1.08 – 2.56), HLA-B*35 (P=0.0218; Pc=0.6758; OR=1.67; 95%CI=1.08 – 2.29) and HLA-B*44 (P=0.0290; Pc=0.8990; OR=1.67; 95%CI=1.05 – 2.64). Subjects with allele HLA-B*27 (P=0.0180; Pc=0.5580; OR=7.1111; 95%CI=1.7850 – 28.3286) tended towards susceptibility to mucocutaneous lesions, those with HLA-B*49 (P=0.0101; Pc=0.3131; OR=6.4000; 95%CI=1.8472 – 22.1743) to recurrent ACL, and HLA-B*52 (P=0.0044; Pc=0.1360; OR=12.61; 95%CI=3.08 – 51.66), to re-infection. Presence of HLA-B*45 (P=0.0107; Pc=0.3317) tended to provide protection against the cutaneous form of ACL. The most frequent haplotypes that may be associated with susceptibility to ACL were A*02 B*44 DRB1*07 (P = 0.0236) and A*24 B*35 DRB1*01 (P = 0.0236).

Conclusion

Some Class I and Class II HLA genes appear to contribute towards susceptibility to and protection against different clinical manifestations of ACL. Other genetic marker studies may contribute toward future prophylactic and therapeutic interventions in ACL.

【 授权许可】

   
2013 Ribas-Silva et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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