Role of life events in the presence of colon polyps among African Americans

BMC Gastroenterology

Mehdi Nouraie¹  Adeyinka O Laiyemo¹  Cheryl L Holt²  Babak Shokrani³  Thomas Mellman¹  Hassan Brim³  Carla Williams¹  Teletia Taylor¹  Hassan Hassanzadeh Namin¹  Hassan Ashktorab¹ 

[1] Cancer Center and Department of Medicine, Howard University College of Medicine, 2041 Georgia Avenue, N.W. Washington, D.C. 20060, USA;Department of Behavioral and, Community Health, Center for Health Behavior Research, School of Public Health, University of Maryland, College Park, Maryland, USA;Department of Pathology, Howard University, college of Medicine, Washington, D.C., USA

关键词: African Americans;    Colon adenoma;    Life events;    Stress;   

Others  :  857898
DOI  :  10.1186/1471-230X-13-101

 received in 2013-02-13, accepted in 2013-05-23,  发布年份 2013

【 摘 要 】

Background

African Americans have disproportionately higher incidence and death rates of colorectal cancer among all ethnic groups in the United States. Several lifestyle factors (e.g. diet, physical activity and alcohol intake) have been suggested as risk factors for colorectal cancer. Stressful life events have also been identified as risk factors for colorectal cancer. The association between stressful life events and colon polyps, which are precursors of colorectal cancer, has yet to be determined.

We aimed to evaluate the relationship between stressful life events and the presence of colon polyps and adenomas in African American men and women.

Methods

In this cross-sectional study, 110 participants were recruited from a colon cancer screening program at Howard University Hospital. Participants completed an 82-item Life Events Questionnaire (Norbeck 1984), assessing major events that have occurred in the participants’ life within the past 12 months. Participants also reported whether the event had a positive or negative impact. Three scores were derived (total, positive, and negative).

Results

Total life events scores were higher (Median [M] = 29 and Interquartile range [IQR] = 18-43) in patients with one or more polyps compared to patients without polyps (M, IQR = 21,13-38; P = 0.029). Total, positive or negative Life Events scores did not differ significantly between normal and adenoma patients. Total, negative and positive Life Events scores did not differ between patients who underwent diagnostic colonoscopy (symptomatic) and patients who underwent colonoscopy for colon cancer screening (asymptomatic) and patients for surveillance colonoscopies due to a personal history of colon polyps. Linear regression analysis indicated that male gender is associated with 9.0 unit lower total Life Events score (P = 0.025).

Conclusion

This study suggests that patients who experienced total life events may be at higher risk of having colon polyps and adenomas which indicates an association between stress and the development of colorectal polyps.

【 授权许可】

   
2013 Ashktorab et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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