Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study

BMC Pregnancy and Childbirth

Kerin O’Dea^1,14  Paul Zimmet^1,11  Jonathan Shaw^1,11  Sue Sayers⁵  Jacqueline Boyle¹  Michael Lynch⁸  Michelle Dowden^1,18  Karen Dempsey^1,13  Chrissie Inglis⁴  Mark Harris^1,16  Monique Stone⁶  Sandra Eades^1,10  Sujatha Thomas²  Sridhar Chitturi⁹  Paula van Dokkum³  Stacey Svenson^1,15  Marie Kirkwood⁵  Sumaria Corpus⁹  Glynis Dent³  Danielle Longmore⁵  Elizabeth Moore^1,17  Cherie Whitbread⁹  Harold D McIntyre^1,12  Jeremy Oats⁷  Christine Connors^1,13  I-Lynn Lee⁵  Alex Brown^1,14  Louise J Maple-Brown⁹ 

[1] Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia;Department of Obstetrics and Gynaecology, Royal Darwin Hospital, Darwin, Australia;Alice Springs Hospital, Northern Territory, Alice Springs, Australia;Healthy Living NT, Darwin, Australia;Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina NT 0811, Darwin, Australia;Department of Paediatrics, Royal Darwin Hospital, Darwin, Australia;Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia;Pathology Network, Top End Health and Hospital Services, Darwin, Australia;Division of Medicine, Royal Darwin Hospital, Darwin, Australia;Sydney Medical School, The University of Sydney, Sydney, Australia;Baker IDI Heart and Diabetes Institute, Melbourne, Australia;Mater Research Institute, University of Queensland, Brisbane, Australia;Northern Territory Department of Health, Darwin, Australia;School of Population Health, University of South Australia, Adelaide, Australia;Baker IDI Heart and Diabetes Institute, Central Australia, Australia;Mater Children’s Hospital, South Brisbane, QLD, Australia;Aboriginal Medical Services Alliance Northern Territory, Darwin, Australia;Aboriginal Health Council of West Australia, Perth, Australia

关键词: Aboriginal;    Indigenous Australian;    Anthropometry;    Neonatal body composition;    Birth weight;    Antenatal care;    Gestational diabetes;    Diabetes in pregnancy;   

Others  :  1131948
DOI  :  10.1186/1471-2393-13-221

 received in 2013-11-03, accepted in 2013-11-22,  发布年份 2013

【 摘 要 】

Background

Diabetes in pregnancy carries an increased risk of adverse pregnancy outcomes for both the mother and foetus, but it also provides an excellent early opportunity for intervention in the life course for both mother and baby. In the context of the escalating epidemic of chronic diseases among Indigenous Australians, it is vital that this risk is reduced as early as possible in the life course of the individual. The aims of the PANDORA Study are to: (i) accurately assess rates of diabetes in pregnancy in the Northern Territory (NT) of Australia, where 38% of babies are born to Indigenous mothers; (ii) assess demographic, clinical, biochemical, anthropometric, socioeconomic and early life development factors that may contribute to key maternal and neonatal birth outcomes associated with diabetes in pregnancy; and (iii) monitor relevant post-partum clinical outcomes for both the mothers and their babies.

Methods/Design

Eligible participants are all NT women with diabetes in pregnancy aged 16 years and over. Information collected includes: standard antenatal clinical information, diagnosis and management of diabetes in pregnancy, socio-economic status, standard clinical birth information (delivery, gestational age, birth weight, adverse antenatal and birth outcomes). Cord blood is collected at the time of delivery and detailed neonatal anthropometric measurements performed within 72 hours of birth. Information will also be collected regarding maternal post-partum glucose tolerance and cardio-metabolic risk factor status, breastfeeding and growth of the baby up to 2 years post-partum in the first instance.

Discussion

This study will accurately document rates and outcomes of diabetes in pregnancy in the NT of Australia, including the high-risk Indigenous Australian population. The results of this study should contribute to policy and clinical guidelines with the goal of reducing the future risk of obesity and diabetes in both mothers and their offspring.

【 授权许可】

   
2013 Maple-Brown et al.; licensee BioMed Central Ltd.

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