The correlation between motor impairments and event-related desynchronization during motor imagery in ALS patients

BMC Neuroscience

Yoshihisa Masakado²  Harumichi Aramaki¹  Junichi Ushiba³  Yuki Ogawa³  Kentaro Terasaki³  Takashi Kasahara² 

[1] Department of Rehabilitation Medicine, National Hokone Hospital, 412 Kazamatsuri, Hokone, Kanagawa 250-0032, Japan;Department of Rehabilitation Medicine, Tokai University School of Medicine, Shimokasuya 143, Isehara, Kanagawa 259-1193, Japan;Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kouhoku-ku, Yokohama, Kanagawa 223-8522, Japan

关键词: Bulbar dysfunction;    Amyotrophic lateral sclerosis;    Brain-computer interface;   

Others  :  1170671
DOI  :  10.1186/1471-2202-13-66

 received in 2012-01-28, accepted in 2012-05-15,  发布年份 2012

【 摘 要 】

Background

The event-related desynchronization (ERD) in EEG is known to appear during motor imagery, and is thought to reflect cortical processing for motor preparation. The aim of this study is to examine the modulation of ERD with motor impairment in ALS patients. ERD during hand motor imagery was obtained from 8 ALS patients with a variety of motor impairments. ERD was also obtained from age-matched 11 healthy control subjects with the same motor task. The magnitude and frequency of ERD were compared between groups for characterization of ALS specific changes.

Results

The ERD of ALS patients were significantly smaller than those of control subjects. Bulbar function and ERD were negatively correlated in ALS patients. Motor function of the upper extremities did was uncorrelated with ERD.

Conclusions

ALS patients with worsened bulbar scales may show smaller ERD. Motor function of the upper extremities did was uncorrelated with ERD.

【 授权许可】

   
2012 Kasahara et al.; licensee BioMed Central Ltd; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

【 参考文献 】

• [1]Hecht M, Hillemacher T, Grasel E, Tigges S, Winterholler M, Heuss D, Hilz MJ, Neundorfer B: Subjective experience and coping in ALS. Amyotroph Lateral Scler Other Motor Neuron Disord 2002, 3:225-231.
• [2]Wolpaw JR, Birbaumer N, McFarland DJ, Pfurtscheller G, Vaughan TM: Brain-computer interfaces for communication and control. J Clin Neurophysiol 2002, 113:767-791.
• [3]Lebedev MA, Nicolelis MA: Brain-machine interfaces: past, present and future. Trends Neurosci 2006, 29:536-546.
• [4]Neuper C, Muller-Putz GR, Scherer R, Pfurtscheller G: Motor imagery and EEG-based control of spelling devices and neuroprostheses. Prog Brain Res 2006, 159:393-409.
• [5]Berger H: Über das Elektrenkephalogramm des MenschenII. J Psychol Neurol 1930, 40:160-179.
• [6]Pfurtscheller G: Graphical display and statistical evaluation of event-related desynchronization (ERD). Electroencephalogr Clin Neurophysiol 1977, 43:757-760.
• [7]Pfurtscheller G, Aranibar A: Event-related cortical desynchronization detected by power measurements of scalp EEG. Electroencephalogr Clin Neurophysiol 1977, 42:817-826.
• [8]Pfurtscheller G, Klimesch W: Functional topography during a visuoverbal judgement task studied with event-related desynchronization mapping. J Clin Neurophysiol 1992, 9:120-131.
• [9]Pfurtscheller G: Lopes da Silva FH. Event-related EEG/MEG synchronization and desynchronization: basic principles. Clin Neurophysiol 1999, 110:1842-1857.
• [10]Kalcher J, Flotzinger D, Neuper C, Golly S, Pfurtscheller G: Granz brain-computer interfaceII: towards communication between humans and computers based on online classification of three different EEG patterns. Med Biol Eng Comput 1996, 34:382-388.
• [11]Pfurtscheller G, Neuper C: Motor imagery activates primary sensorimotor area in humans. Neurosci Lett 1997, 239:65-68.
• [12]Francis K, Bach JR, DeLisa JA: Evaluation and rehabilitation of patients with adult motor neuron disease. Arch Phys Med Rehabil 1999, 80:951-963.
• [13]Kübler A, Birbaumer N: Brain-computer interfaces and communication in paralysis: extinction of goal directed thinking in completely paralysed patients? Clin Neurophysiol 2008, 119:2658-2666.
• [14]Lacomblez L, Bouche P, Bensimon G, Meininger V: A double-blind, placebo-controlled trial of high doses of gangliosides in amyotrophic lateral sclerosis. Neurology 1989, 39:1635-1637.
• [15]Santhosh J, Bhatia M, Sahu S, Anand S: Quantitative EEG analysis for assessment to ‘plan’ a task in amyotrophic lateral sclerosis patients: a study of executive functions (planning) in ALS patients. Cogn Brain Res 2004, 22:59-66.
• [16]Kübler A, Niiboer F, Mellinger J, Vaughan TM, Pawelzik H, Schalk G, McFarland DJ, Birbaumer N, Wolpaw JR: Patients with ALS can use sensorimotor rhythms to operate a brain-computer interface. Neurology 2005, 64:1775-1777.
• [17]Bai O, Lin P, Vorbach S, Floeter MK, Hattori N, Hallett M: A high performance sensorimotor beta rhythm-based brain-computer interface associated with human natural motor behavior. J Neural Eng 2008, 5:24-35.
• [18]Bai O, Lin P, Huang D, Fei DY, Floeter MK: Towards a user-friendly brain- computer interface: Initial tests in ALS and PLS patients. Clin Neurophysiol 2010, 121:1293-1303.
• [19]Eisen A, Entezari-Taher M, Stewart H: Cortical projections to spinal motoneurons: changes with aging and amyotrophic lateral sclerosis. Neurology 1996, 46:1396-1404.
• [20]Hamada T, Koshino Y, Tsubokawa M: Mu rhythm no nendaibestu syutugen hind. Rinsyo-byouri 1989, 22:194-198. in Japanese
• [21]Sailer A, Dichingans J, Gerloff C: The influence of normal aging on the cortical processing of a simple motor task. Neurology 2000, 55:979-985.
• [22]Labyt E, Szurhaj W, Bourriez JL, Cassim F, Defebvre L, Destee A, Guieu JD, Derambure P: Changes in oscillatory cortical activity related to a visuomotor task in young and elderly healthy subjects. Clin Neurophysiol 2003, 114:1153-1166.
• [23]Mai R, Facchetti D, Micheli A, Poloni M: Quantitative electroencephalography in amyotrophic lateral sclerosis. Electroencephalogr Clin Neurophysiol 1998, 1060:383-386.
• [24]Malouin F, Richards CL, Durand A, Doyon J: Reliability of mental chronometry for assessing motor imagery ability after stroke. Arch Phys Med Rehabil 2008, 89:311-319.
• [25]Marks DF, Issac AR: Topographical distribution of EEG activity accompanying visual and motor imagery in vivid and non-vivid imagers. Br J Psychol 1995, 86:271-282.
• [26]Endo T, Tezuka S, Sato Y: An Experimental study of a preventive measure against drowsiness in a car driving. J Transport Med 1982, 36:195-204. in Japanese
• [27]Wilkinson L, Scholey A, Wesnes K: Chewing gum selectively improves aspects of memory in healthy volunteers. Appetite 2002, 38:235-236.
• [28]Sakamoto K, Nakata H, Kakigi R: The effect of mastication on human cognitive processing: a study using event-related potentials. J Clin Neurophysiol 2009, 120:41-50.
• [29]Abrahams S, Goldstein LH, Chalabi AI, Pickering A, Morris RG, Passingham RE, et al.: Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 1997, 62:464-472.
• [30]Kim SM, Lee KM, Hong YH, et al.: Relation between cognitive dysfunction and reduced vital capacity in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2007, 78:1387-1389.
• [31]Stancak A, Pfurtscheller G: The effect of handness and type of movement on the contralateral preponderance of μ-rhythm desynchronisation. Electroencephalogr Clin Neurophysiol 1996, 99:174-182.
• [32]Derambure P, Defebvre L, dujardin K, Bourriez JL, Jacquesson JM, Destee A, Guieu JD: Effect of aging on the spatio-temporal pattern of event-related desynchonization during a voluntary movement. Electroencephalogr Clin Neurophysiol 1993, 89:197-203.
• [33]Labyt E, Szurhaj W, Bourriez JL, Cassim F, Defebvre L, Destee A, Derambure P: Influence of aging on cortical activity associated with a visuo-motor task. Neurobiol Aging 2004, 25:817-827.
• [34]World Federation of Neurology Research Group on Neuromuscular Diseases(1994): El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. J Neurol Sci 1994, 124:96-107.
• [35]Neuper C, Scherer R, Reiner M, Pfurtscheller G: Imagery of motor actions: differential effects of kinesthetic and visual-motor mode of imagery in single-trial EEG. Brain Res Cogn Brain Res 2005, 25:677-688.
• [36]Hjorth B: An on-line transformation of EEG scalp potentials into orthogonal source derivations. Electroencephalogr Clin Neurophysiol 1975, 39:526-530.
• [37]Welch PD: The use of fast fourier transform for the estimation of power spectra: a method based on time averaging over short, modified periodograms. IEEE Trans. Audio Electroacoust 1967, 15:70-73.