Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network)

BMC Infectious Diseases

Gláucia Paranhos-Baccalà^1,11  Philippe Vanhems⁸  Hubert Endtz^1,11  Guy Vernet^1,11  Florence Komurian-Pradel^1,11  Patricia Barreto⁴  Marilda M Siqueira⁴  Wilma Basualdo⁹  Graciela Russomando⁵  Budragchaagiin Dash-Yandag^1,14  Pagbajabyn Nymadawa^1,12  Souleymane Diallo^1,13  Maryam Sylla¹  Jonathan Hoffmann^1,16  Bénédicte Contamin^1,16  Annick Robinson^1,17  Sonali Sanghvi⁶  Ashish Bavdekar⁶  Nitin Pandey²  Shally Awasthi²  Vanessa Rouzier^1,15  Jean-William Pape^1,15  Kunling Shen^1,18  Jianwei Wang³  Tekchheng Eap⁷  Monidarin Chou^1,10  Jean-Noël Telles^1,11  Melina Messaoudi^1,11  Thomas Bénet⁸  Valentina Sanchez Picot^1,11 

[1] Gabriel Touré Hospital, Bamako, Mali;Chatrapati Shahuji Maharaj University, Lucknow, India;MOH Key Laboratory of Systems Biology of Pathogens and Dr. Christophe Mérieux Laboratory, IPB, CAMS-Fondation Mérieux, Institute of Pathogen Biology (IPB), Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College), Beijing, China;Respiratory virus Laboratory, Oswaldo Cruz Foundation, Hospital Bonsucesso, Rio de Janeiro, Brazil;Research Institute of Health, Asuncion, Paraguay;KEM Hospital Research Center, Pune, India;Department of Pneumology, National Pediatric Hospital, Phnom Penh, Cambodia;Epidemiology and Public Health Unit, University of Lyon 1, Lyon, France;Hospital Pediátrico “Niños de Acosta Ñu”, San Lorenzo, Paraguay;Faculty of Pharmacy, University of Health Sciences, Phnom Penh, Cambodia;Emerging Pathogens Laboratory – Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI) Inserm U1111, CNRS UMR5308, ENS de Lyon, UCBL1, 21, Avenue Tony Garnier, Lyon 69007, France;Mongolian Academy of Medical Sciences, Ulaanbaatar, Mongolia;Centre d’Infectiologie Charles Mérieux (CICM), Bamako, Mali;Bayanzurkh District General Hospital, Ulaanbaatar, Mongolia;GHESKIO (Groupe Haïtien d’Etude du Sarcome de Kaposi et des Infections Opportunistes) Centers, Port au Prince, Haiti;Fondation Mérieux, Centre d’Infectiologie Charles Mérieux (CICM), Antananarivo, Madagascar;Hôpital Femme-Mère-Enfant, Antananarivo, Madagascar;Key Laboratory of Major Diseases in Children and National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, China

关键词: Developing and emerging countries;    Etiology;    Case–control;    Children;    Pneumonia;   

Others  :  1118083
DOI  :  10.1186/s12879-014-0635-8

 received in 2014-08-11, accepted in 2014-11-17,  发布年份 2014

【 摘 要 】

Background

Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case–control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia.

Methods/design

A multicenter case–control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children <5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples.

Discussion

This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention.

【 授权许可】

   
2014 Picot et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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