Sero-positivity rate of rubella and associated factors among pregnant women attending antenatal care in Mwanza, Tanzania

BMC Pregnancy and Childbirth

Uwe Groß²  Charles Majinge¹  Domenica Morona⁴  Denna Michael³  Benson R Kidenya⁵  Anthony N Massinde¹  Stephen E Mshana⁴  Mariam M Mirambo⁴  Berno Mwambe¹ 

[1] Department of Obstetrics and Gynaecology, Catholic University of Health and Allied Sciences, Box 1464, Mwanza, Tanzania;Institute of Medical Microbiology, Göttingen University Medical Center, Göttingen, Germany;National Institute of Medical Research Mwanza, Ocean Road, P.O.BOX 9653, Dar es salaam 2448, Tanzania;Department of Microbiology/Immunology, Catholic University of Health and Allied Sciences, Box 1464, Mwanza, Tanzania;Department of Biochemistry and Molecular Biology, Catholic University of Health and Allied Sciences, Box 1464, Mwanza, Tanzania

关键词: Tanzania;    Mwanza;    Pregnancy;    Rubella;    Prevalence;   

Others  :  1127523
DOI  :  10.1186/1471-2393-14-95

 received in 2013-06-17, accepted in 2014-02-26,  发布年份 2014

【 摘 要 】

Background

Sero-positivity rates of the rubella virus among pregnant women vary widely throughout the world. In Tanzania, rubella vaccination is not included in the national immunization schedule and there is therefore no antenatal screening for this viral disease. So far, there are no reports on the sero-prevalence of rubella among pregnant women in Tanzania. As a result, this study was undertaken to establish the sero-positivity rate of rubella and rubella risk factors among pregnant women attending antenatal care clinics in Mwanza, Tanzania.

Methods

From November 2012 to May 2013 a total of 350 pregnant women were enrolled and their serum samples collected and analyzed using the AXSYM anti-rubella virus IgG/IgM-MEIA test. Demographic and clinical data were collected using a standardized data collection tool. Data analysis was done using STATA version 12.

Results

Of 342 pregnant women tested for rubella antibodies, 317 (92.6%) were positive for anti-rubella IgG while only 1 (0.3%) was positive for IgM. Higher sero-positivity rates were found in the age group of 25–44 years. Furthermore, it was observed that with each year increase in age, the risk of contracting rubella increases by 12% (OR = 1.12, 95% CI: 1.02-1.22, P = 0.019). Women involved in farming and business women were at a higher risk of contracting rubella infection compared to formally employed women (OR: 4.9, P = 0.011; OR 7.1, p = 0.003 respectively). In univariate analysis, the risk of contracting rubella virus infection was found to increase with gestational age with a statistical significance.

Conclusions

Sero-positivity rates of rubella are high in Mwanza and are significantly associated with an increase in age and being a farmer or a business woman. Screening of rubella and immunization of women at risk are highly recommended in this area with a high non-immune rate against rubella virus.

【 授权许可】

   
2014 Mwambe et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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