Laxative effects of Salecan on normal and two models of experimental constipated mice

BMC Gastroenterology

Jianfa Zhang¹  Peng Chen¹  Yibei Zhan¹  Yue Zhao¹  Aihui Xiu¹  Jinping Chen¹  Ping Jia¹  Mengyi Zhou¹ 

[1] Center for Molecular Metabolism, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing, 210094, China

关键词: Clonidine;    Loperamide;    Intestinal motility;    Constipation;    Salecan;   

Others  :  858113
DOI  :  10.1186/1471-230X-13-52

 received in 2012-11-17, accepted in 2013-03-14,  发布年份 2013

【 摘 要 】

Background

Constipation is one of the most common gastrointestinal complaints with a highly prevalent and often chronic functional gastrointestinal disorder affecting health-related quality of life. The aim of the present study was to evaluate the effects of Salecan on fecal output and small intestinal transit in normal and two models of drug-induced constipation mice.

Methods

ICR mice were administrated intragastrically (i.g.) by gavage with 100, 200 and 300 mg/kg body weight (BW) of Salecan while the control mice were received saline. The constipated mice were induced by two types of drugs, loperamide (5 mg/kg BW, i.g.) and clonidine (200 μg/kg BW, i.g.), after Salecan treatment while the control mice were received saline. Number, weight and water content of feces were subsequently measured. Small intestinal transit was monitored by phenol red marker meal.

Results

Salecan (300 mg/kg BW) significantly increased the number and weight of feces in normal mice. In two models of drug-induced constipation, Salecan dose-dependently restored the fecal number and fecal weight. The water content of feces was markedly affected by loperamide, but not by clonidine. Treatment with Salecan significantly raised the fecal water content in loperamide-induced constipation mice. Moreover, Salecan markedly stimulated the small intestinal transit in both loperamide- and clonidine-induced constipation model mice.

Conclusions

These results suggest that Salecan has a potential to be used as a hydrophilic laxative for constipation.

【 授权许可】

   
2013 Zhou et al.; licensee BioMed Central Ltd.

【 图 表 】

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