Mobile-phone-based home exercise training program decreases systemic inflammation in COPD: a pilot study

BMC Pulmonary Medicine

Han-Pin Kuo¹  Kian Fan Chung²  Fu-Tsai Chung¹  Chien-Da Huang¹  Horng-Chyuan Lin¹  Shu-Chuan Ho³  Te-Fang Sheng¹  Li-Fei Chen¹  Wen-Ching Joa¹  Pai-Chien Chou¹  Chun-Hua Wang¹ 

[1] Department of Thoracic Medicine, Chang Gung Memorial Hospital, 199 Tun-Hwa North Road, Taipei, Taiwan;National Heart & Lung Institute, Imperial College, London, UK;School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan

关键词: Interleukin-8;    Biomarker;    Mobile phone;    Pulmonary rehabilitation;    Chronic obstructive pulmonary disease;   

Others  :  1109533
DOI  :  10.1186/1471-2466-14-142

 received in 2014-03-11, accepted in 2014-08-26,  发布年份 2014

【 摘 要 】

Background

Moderate-intensity exercise training improves skeletal muscle aerobic capacity and increased oxidative enzyme activity, as well as exercise tolerance in COPD patients.

Methods

To investigate whether the home-based exercise training program can reduce inflammatory biomarkers in patients with COPD, twelve patients using mobile phone assistance and 14 with free walk were assessed by incremental shuttle walk test (ISWT), spirometry, strength of limb muscles, and serum C-reactive protein (CRP) and inflammatory cytokines.

Results

Patients in the mobile phone group improved their ISWT walking distance, with decrease in serum CRP after 2 months, and sustained at 6 months. Patients in the control group had no improvement. Serum IL-8 in the mobile phone group was significantly reduced at 2, 3 and 6 months after doing home exercise training compared to baseline. IL-6 and TNF-α were significantly elevated at 3 and 6 months in control group, while there were no changes in mobile phone group. The strength of limb muscles was significantly greater compared to baseline at 3 and 6 months in the mobile phone group.

Conclusions

A mobile-phone-based system can provide an efficient home endurance exercise training program with improved exercise capacity, strength of limb muscles and a decrease in serum CRP and IL-8 in COPD patients. Decreased systemic inflammation may contribute to these clinical benefits. (Clinical trial registration No.: NCT01631019)

【 授权许可】

   
2014 Wang et al.; licensee BioMed Central Ltd.

【 图 表 】

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