期刊论文详细信息
BMC Research Notes
Sudden cardiac death diagnosed with dilated cardiomyopathy in a Kuwaiti family: a case report
Maisa Mahmoud Kamkar1  Daisy Thomas1  Osama Alsmadi1  Kazem Behbehani3  Dinu Antony1  Bassam Bulbanat2 
[1] Genetics and Genomics Unit/Dasman Genome Center, Biomedical Research Department, Dasman Diabetes Institute, Kuwait City, Kuwait;Division of Cardiology, Al-Amiri Hospital, Ministry of Health, P.O. Box 1180, Dasman 15462, Kuwait;Dasman Diabetes Institute, Kuwait City, Kuwait
关键词: Sudden arrhythmic death;    Familial dilated cardiomyopathy;    Cardiomyopathies;   
Others  :  1091919
DOI  :  10.1186/1756-0500-7-914
 received in 2014-05-06, accepted in 2014-12-11,  发布年份 2014
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【 摘 要 】

Background

Dilated cardiomyopathy is myocardial disease characterized by dilatation and impaired contraction of the left ventricle or both left and right ventricle. The majority of these cases are secondary to coronary artery disease, hypertension and valvular cardiomyopathy. Patients diagnosed with dilated cardiomyopathy are further clinically evaluated for evidence of familial history of the disease. Those families have shown to have genetic predisposition to dilated cardiomyopathy; thus, currently there is no available single genetic test that allows comprehensive testing of all causative genes. We report a Kuwaiti case of dilated cardiomyopathy that was diagnosed at young age. The patient clinical presentation pointed out to the fact that this was a familial disease. This case is the first reported in Kuwait clinically presented with familial dilated cardiomyopathy implying a genetic susceptibility factor to be further investigated within the at-risk family members.

Case presentation

23-year-old Arab ethnicity Kuwaiti male with strong family history of dilated cardiomyopathy was admitted witnessed with sudden cardiac death. The patient presented with sudden arrhythmic death and survived with permanent anoxic brain injury. Transthoracic echocardiography revealed dilated cardiomyopathy with severe global left ventricular systolic dysfunction. After thorough investigation, the patient shown to have strong family history of dilated cardiomyopathy.

Conclusion

Familial dilated cardiomyopathy is poorly documented in Kuwait. We present this case with future plan to study the genetic map of his family.

【 授权许可】

   
2014 Bulbanat et al.; licensee BioMed Central.

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