Molecular mimicry, inflammatory bowel disease, and the vaccine safety debate

BMC Medicine

Jonathan Braun¹  Susy Yusung² 

[1] Department of Pathology and Laboratory Medicine, UCLA, 10833 Le Conte Ave, Los Angeles 90095, CA, USA;Department of Pediatrics, Harbor-UCLA Medical Center, 1000 W Carson St, Torrance 90502, CA, USA

关键词: epitope spreading;    humoral immunity;    Ulcerative Colitis;    Crohn’s Disease;   

Others  :  1121440
DOI  :  10.1186/s12916-014-0166-6

 received in 2014-08-29, accepted in 2014-08-29,  发布年份 2014

【 摘 要 】

Preventive immunization has provided one of the major advances in population health during the past century. However, a surprising cultural phenomenon is the emergence of concerns about immunization safety, in part due to prominently controversial biomedical studies. One ongoing theoretical safety concern is the possibility of human molecular mimicry by measles, mumps, rubella (MMR) antigens. The study of Polymeros et al. in this BMC Medicine presents a systematic evaluation and refutation of this safety concern. This provides significant new scientific evidence in support of the safety of pediatric vaccines, which will inform the ongoing policy and cultural understanding of this important public health measure.

Please see related research article: http://www.biomedcentral.com/1741-7015/12/139/abstract webcite.

【 授权许可】

   
2014 Yusung and Braun; licensee BioMed Central Ltd.

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