Effects of coffee, smoking, and alcohol on liver function tests: a comprehensive cross-sectional study

BMC Gastroenterology

Dong Ho Lee²  Nayoung Kim³  Jin-Wook Kim³  Jin Hyeok Hwang³  Young Soo Park³  Sang Hyub Lee³  Jaebong Lee¹  So Yeon Ahn¹  Hyun Young Kim²  Sung Ho Hwang³  Sook-Hyang Jeong³  Eun Sun Jang³ 

[1] Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 166 Gumi-ro, Bundang-gu, Seongnam-si, 463-707, Gyeonggi-do, Republic of Korea;Health Promotion Center, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 166 Gumi-ro, Bundang-gu, Seongnam-si, 463-707, Gyeonggi-do, Republic of Korea;Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 166 Gumi-ro, Bundang-gu, Seongnam-si, 463-707, Gyeonggi-do, Republic of Korea

关键词: Gamma-glutamyltransferase;    Liver function tests;    Smoking;    Alcohols;    Coffee;   

Others  :  858335
DOI  :  10.1186/1471-230X-12-145

 received in 2012-05-31, accepted in 2012-10-10,  发布年份 2012

【 摘 要 】

Background

Liver function tests (LFTs) can be affected by many factors and the proposed effects of coffee on LFT require a comprehensive evaluation. The aim of this study was to elucidate whether drinking coffee, smoking, or drinking alcohol have independent effects on LFTs in Korean health-check examinees.

Methods

We used the responses of 500 health-check examinees, who had participated in a self-administered questionnaire survey about coffee, alcohol drinking, and smoking habits.

Results

Coffee consumption was closely related to male gender, high body mass index (BMI), alcohol drinking, and smoking. On univariable and multivariable analyses, drinking coffee lowered serum levels of total protein, albumin, and aspartate aminotransferases (AST). On multivariable analyses, smoking raised serum γ-glutamyl transferase (GGT) level and decreased serum protein and albumin levels, while alcohol drinking raised GGT level after adjustment for age, gender, regular medication, BMI, coffee and alcohol drinking amounts, and smoking.

Conclusions

Coffee consumption, smoking, and alcohol drinking affect the individual components of LFT in different ways, and the above 3 habits each have an impact on LFTs. Therefore, their effects on LFTs should be carefully interpreted, and further study on the mechanism of the effects is warranted.

【 授权许可】

   
2012 Jang et al.; licensee BioMed Central Ltd.

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