Peritumoral ductular reaction: a poor postoperative prognostic factor for hepatocellular carcinoma

BMC Cancer

Minhui Xu²  Feng Xie¹  Guangyang Qian²  Yingying Jing²  Shanshan Zhang²  Lu Gao²  Tao Zheng¹  Mengchao Wu¹  Jiamei Yang¹  Lixin Wei² 

[1] Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China

[2] Tumor Immunology & Gene Therapy Center, Eastern Hepatobiliary Hospital, The Second Military Medical University, Changhai Road, Shanghai 200438, China

关键词: Prognosis;    Hepatocellular carcinoma (HCC);    Fibrosis;    Necroinflammation;    Hepatic progenitor cells (HPCs);    Ductular reaction (DR);   

Others  :  859092
DOI  :  10.1186/1471-2407-14-65

 received in 2013-10-07, accepted in 2014-02-03,  发布年份 2014

【 摘 要 】

Background

The role of ductular reaction (DR) in hepatocellular carcinoma (HCC) remains to be elucidated.

Methods

In this study, we tried to uncover possible effect by correlating peritumoral DR in a necroinflammatory microenvironment with postoperative prognosis in HCC. The expression of peritumoral DR/CK19 by immunohistochemistry, necroinflammation and fibrosis were assessed from 106 patients receiving curative resection for HCC. Prognostic values for these and other clinicopathologic factors were evaluated.

Results

Peritumoral DR significantly correlated with necroinflammation (r = 0.563, p = 3.4E-10), fibrosis (r = 0.435, p = 3.1E-06), AFP level (p = 0.010), HBsAg (p = 4.9E-4), BCLC stage (p = 0.003), TNM stage (p = 0.002), multiple nodules (p = 0.004), absence of tumor capsule (p = 0.027), severe microscopic vascular invasion (p = 0.031) and early recurrence (p = 0.010). Increased DR was significantly associated with decreased RFS/OS (p = 4.8E-04 and p = 2.6E-05, respectively) in univariate analysis and were identified as an independent prognostic factor (HR = 2.380, 95% CI = 1.250-4.534, p = 0.008 for RFS; HR = 4.294, 95% CI = 2.255-8.177, p = 9.3E-6 for OS) in multivariate analysis.

Conclusions

These results suggested that peritumoral DR in a necroinflammatory microenvironment was a poor prognostic factor for HCC after resection.

【 授权许可】

   
2014 Xu et al.; licensee BioMed Central Ltd.

【 图 表 】

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