TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine

BMC Complementary and Alternative Medicine

Jeong-Ju Lee¹  Anna Kim²  Hyunchul Jang²  SeJin Nam³  Sang-Kyun Kim² 

[1] Human Derived Material Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea;Mibyeong Research Center, Korea Institute of Oriental Medicine, Daejeon, South Korea;Biomedical Knowledge Engineering Laboratory, Seoul National University, Seoul, South Korea

关键词: Database;    Curation;    Chromatography;    Northeast Asia;    Traditional medicine;    Ingredient;    Chemical compound;    Herb;    Medicinal material;   

Others  :  1220069
DOI  :  10.1186/s12906-015-0758-5

 received in 2015-04-14, accepted in 2015-07-01,  发布年份 2015

【 摘 要 】

Background

In traditional medicine, there has been a great deal of research on the effects exhibited by medicinal materials. To study the effects, resources that can systematically describe the chemical compounds in medicinal materials are necessary. In recent years, numerous databases on medicinal materials and constituent compounds have been constructed. However, because these databases provide differing information and the sources of such information are unclear or difficult to verify, it is difficult to decide which database to use. Moreover, there is much overlapping information. The aim of this study was to construct a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine (TM-MC), for which medicinal materials are listed in the Korean, Chinese, and Japanese pharmacopoeias and information on the compound names of medicinal materials can easily be confirmed online.

Description

To provide information on the chemical compounds of medicinal materials, chromatography articles from MEDLINE and PubMed Central were searched. After chemical compounds of medicinal materials were extracted by manually investigating the full-text of articles, a database of information on about 14,000 compounds from 536 medicinal materials was built. The database also provides links to the articles from which each medicinal material and chemical compound were extracted.

Conclusion

TM-MC database provides information on medicinal materials and their chemical compounds from chromatography articles in MEDLINE and PubMed Central. Researchers can easily check relevant information through the links to articles.

【 授权许可】

   
2015 Kim et al.

【 图 表 】

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【 参考文献 】

• [1]Ru J, Li P, Wang J, Zhou W, Li B, Huang C, Li P, Guo Z, Tao W, Yang Y, Xu X, Li Y, Wang Y, Yang L. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform. 2014; 6:13. BioMed Central Full Text
• [2]Xue R, Fang Z, Zhang M, Yi Z, Wen C, Shi T. TCMID: Traditional Chinese Medicine integrative database for herb molecular mechanism analysis. Nucleic Acids Res. 2013; 41:D1089-1095.
• [3]Chen X, Zhou H, Liu YB, Wang JF, Li H, Ung CY, Han LY, Cao ZW, Chen YZ. Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation. Br J Pharmacol. 2006; 149(8):1092-1103.
• [4]Chen CY. TCM Database@Taiwan: the world's largest traditional Chinese medicine database for drug screening in silico. PLoS One. 2011; 6(1): Article ID e15939
• [5]Zhou J, Xie G, Yan X. Encyclopedia of traditional Chinese medicines molecular structures, pharmacological activities, natural sources and applications. Springer, New York; 2011.
• [6]Feng Y, Wu Z, Zhou X, Zhou Z, Fan W. Knowledge discovery in traditional Chinese medicine: state of the art and perspectives. Artif Intell Med. 2006; 38(3):219-236.
• [7]Lukman S, He Y, Hui SC. Computational methods for Traditional Chinese Medicine: a survey. Comput Methods Programs Biomed. 2007; 88(3):283-294.
• [8]Ehrman TM, Barlow DJ, Hylands PJ. Phytochemical databases of Chinese herbal constituents and bioactive plant compounds with known target specificities. J Chem Inf Model. 2007; 47(2):254-263.
• [9]Hsu HY, Chen YP, Hong M. The chemical constituents of oriental herbs. Oriental Healing Arts Institute, Taiwan; 1982.
• [10]Zhu Y-P. Chinese materia medica: chemistry, pharmacology and applications. Harwood Academic, Amsterdam, Netherlands; 1998.
• [11]Yan X, Milne GWA, Zhou J, Xie G. Traditional Chinese medicines: molecular structures, natural sources, and applications. Ashgate, Aldershot; 1999.
• [12]Duke JA. Handbook of phytochemical constituents of GRAS herbs and other economic plants. CRC Press, Boca Raton; 2001.
• [13]Buckingham J. Dictionary of natural products. Chapman & Hall, New York; 1994.
• [14]He M, Yan X, Zhou J, Xie G. Traditional Chinese medicine database and application on the Web. J Chem Inf Comput Sci. 2001; 41(2):273-277.
• [15]Qiao XB, Hou TJ, Yu HD, Xu XJ. Research and development of traditional Chinese medicine drugs information system based on networks. Acta Physico-Chimica Sinica. 2002; 18(5):394-398.
• [16]Qiao XB, Hou TJ, Zhang W, Guo SL, Xu SJ. A 3D structure database of components from Chinese traditional medicinal herbs. J Chem Inf Comput Sci. 2002; 42(3):481-489.
• [17]Chang IM. Anti-aging and health-promoting constituents derived from traditional oriental herbal remedies: information retrieval using the TradiMed 2000 DB. Ann N Y Acad Sci. 2001; 928:281-286.
• [18]Valli M, dos Santos RN, Figueira LD, Nakajima CH, Castro-Gamboa I, Andricopulo AD, Bolzani VS. Development of a natural products database from the biodiversity of Brazil. J Nat Prod. 2013; 76(3):439-444.
• [19]Ntie-Kang F, Mbah JA, Mbaze LM, Lifongo LL, Scharfe M, Hanna JN, Cho-Ngwa F, Onguene PA, Owono Owono LC, Megnassan E, Sippl W, Efange SM. CamMedNP: building the Cameroonian 3D structural natural products database for virtual screening. BMC Complement Altern Med. 2013; 13:88. BioMed Central Full Text
• [20]Ntie-Kang F, Onguene PA, Scharfe M, Owono LCO, Megnassan E, Mbaze LM, Sippl W, Efange SMN. ConMedNP: a natural product library from Central African medicinal plants for drug discovery. Rsc Advances. 2014; 4(1):409-419.
• [21]Ntie-Kang F, Zofou D, Babiaka SB, Meudom R, Scharfe M, Lifongo LL, et al. A select highly potent and diverse natural product library from African medicinal plants. Plos One. 2013;8(10):e78085.
• [22]Ntie-Kang F, Amoa Onguene P, Fotso GW, Andrae-Marobela K, Bezabih M, Ndom JC, Ngadjui BT, Ogundaini AO, Abegaz BM, Meva'a LM. Virtualizing the p-ANAPL library: a step towards drug discovery from African medicinal plants. PLoS One. 2014; 9(3): Article ID e90655
• [23]Ntie-Kang F, Nwodo JN, Ibezim A, Simoben CV, Karaman B, Ngwa VF, Sippl W, Adikwu MU, Mbaze LM. Molecular modeling of potential anticancer agents from African medicinal plants. J Chem Inf Model. 2014; 54(9):2433-2450.
• [24]Mangal M, Sagar P, Singh H, Raghava GP, Agarwal SM. NPACT: Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target database. Nucleic Acids Res. 2013; 41:D1124-1129.
• [25]Sharma A, Dutta P, Sharma M, Rajput NK, Dodiya B, Georrge JJ, et al. BioPhytMol: a drug discovery community resource on anti-mycobacterial phytomolecules and plant extracts. J Cheminformatics. 2014;6.
• [26]McCandless M, Hatcher E, Gospodnetić O, Gospodnetić O. Lucene in action. 2nd ed. Greenwich, Manning; 2010.
• [27]Jang H, Kim J, Kim SK, Kim C, Bae SH, Kim A, Eom DM, Song MY. Ontology for medicinal materials based on traditional Korean medicine. Bioinformatics. 2010; 26(18):2359-2360.
• [28]Wang Y, Xiao J, Suzek TO, Zhang J, Wang J, Bryant SH. PubChem: a public information system for analyzing bioactivities of small molecules. Nucleic Acids Res. 2009; 37:W623-633.