Change in quality of life: a follow up study among patients with HIV infection with and without TB in Ethiopia

BMC Public Health

Robert Colebunders¹  Todd Maja⁵  Yohannes Hailmichael²  Markos Tesfaye⁶  Ayalu A Reda⁴  Kebede Deribe³  Amare Deribew³ 

[1] Department of Epidemiology and Social Medicine, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, Antwerpen, 2610, Belgium;Department of Health Service management, Jimma University, Jimma, Ethiopia;Department of Epidemiology, Jimma University, Jimma, Ethiopia;College of Public Health, Haromaya University, Alemaya, Ethiopia;Department of Health Studies, UNISA, PO Box 392, Pretoria, South Africa;Department of psychiatry, Jimma University, Jimma, Ethiopia

关键词: Ethiopia;    Common mental disorders;    Antiretroviral treatment;    Quality of life;    TB/HIV co-infection;   

Others  :  1162273
DOI  :  10.1186/1471-2458-13-408

 received in 2012-12-21, accepted in 2013-04-25,  发布年份 2013

【 摘 要 】

Background

There is a dearth of literature on the impact of TB/HIV co-infection on quality of life (QoL). We conducted a study to assess the change in QoL over a 6-months period and its predictors among HIV-infected patients with and without TB in Ethiopia.

Methods

465 HIV-infected patients without TB and 124 TB/HIV co-infected patients were enrolled in a prospective study in February, 2009. 455 (98%) HIV-infected and 97 (78%) TB/HIV co-infected patients were followed for 6 months. Data on QoL at baseline and 6^th month were collected by trained nurses through face to face interviews using the short Amharic version of the World Health Organization Quality of Life Instrument for HIV clients (WHOQOL HIV-Brief). Common Mental Disorder (CMD) was assessed using a validated version of the Kessler-10 scale. Multivariate analysis was conducted using generalized estimating equations (GEE) using STATA to assess change in QoL and its predictors.

Results

There was a statistically significant improvement of the physical, psychological, social, environmental and spiritual QoL at the 6^th months follow up compared to the baseline for both groups of patients (P < 0.0001). The change in QoL in all dimension were more marked for TB/HIV co-infected patients compared to HIV-infected patients without TB.

A severe form of CMD was strongly associated with poorer physical QoL among TB/HIV co-infected individuals (β = −2.84; P = 0.000) and HIV clients without TB (β = −2.34; P = 0.000).

Conclusion

This study reveals that ART and anti-TB treatment significantly improve the QoL particularly among TB/HIV co-infected patients. We recommend that the ministry of health in collaboration with partners shall integrate mental health services into the TB/HIV programs and train health care providers to timely identify and treat CMD to improve QoL.

【 授权许可】

   
2013 Deribew et al.; licensee BioMed Central Ltd.

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