BMC Endocrine Disorders | |
Is dietary zinc protective for type 2 diabetes? Results from the Australian longitudinal study on women’s health | |
John Attia2  Deborah Loxton3  Julie Byles3  Amanda Patterson5  David Sibbritt4  Md Rafiqul Islam4  Abul Hasnat Milton4  Zumin Shi1  Mark McEvoy4  Khanrin Phungamla Vashum4  | |
[1] Discipline of Medicine, University of Adelaide, Adelaide, South Australia;Hunter Medical Research Institute, and Department of General Medicine, John Hunter Hospital, Newcastle, Australia;Research Centre for Gender, Health and Ageing, University of Newcastle, Newcastle, New South Wales, Australia;Centre for Clinical Epidemiology & Biostatistics, School of Medicine & Public Health, University of Newcastle, HMRI Building, Callaghan-2308 Newcastle, NSW, Australia;School of Health Sciences, University of Newcastle, Newcastle, Australia | |
关键词: Zinc; Women & Australia; Diabetes; | |
Others : 1085631 DOI : 10.1186/1472-6823-13-40 |
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received in 2013-07-05, accepted in 2013-09-18, 发布年份 2013 | |
【 摘 要 】
Background
Animal studies have shown that zinc intake has protective effects against type 2 diabetes, but few studies have been conducted to examine this relationship in humans. The aim of this study is to investigate if dietary zinc is associated with risk of type 2 diabetes in a longitudinal study of mid-age Australian women.
Methods
Data were collected from a cohort of women aged 45-50 years at baseline, participating in the Australian Longitudinal Study on Women’s Health. A validated food frequency questionnaire was used to assess dietary intake and other nutrients. Predictors of 6-year incidence of type 2 diabetes were examined using multivariable logistic regression.
Results
From 8921 participants, 333 incident cases of type 2 diabetes were identified over 6 years of follow-up. After adjustment for dietary and non-dietary factors, the highest quintile dietary zinc intake had almost half the odds of developing type 2 diabetes (OR = 0.50, 95% C.I. 0.32–0.77) compared with the lowest quintile. Similar findings were observed for the zinc/iron ratio; the highest quintile had half the odds of developing type 2 diabetes (OR = 0.50, 95% C.I 0.30-0.83) after multivariable adjustment of covariates.
Conclusions
Higher total dietary zinc intake and high zinc/iron ratio are associated with lower risk of type 2 diabetes in women. This finding is a positive step towards further research to determine if zinc supplementation may reduce the risk of developing type 2 diabetes.
【 授权许可】
2013 Vashum et al.; licensee BioMed Central Ltd.
【 预 览 】
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20150113175037650.pdf | 171KB | download |
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