Is dietary zinc protective for type 2 diabetes? Results from the Australian longitudinal study on women’s health

BMC Endocrine Disorders

John Attia²  Deborah Loxton³  Julie Byles³  Amanda Patterson⁵  David Sibbritt⁴  Md Rafiqul Islam⁴  Abul Hasnat Milton⁴  Zumin Shi¹  Mark McEvoy⁴  Khanrin Phungamla Vashum⁴ 

[1] Discipline of Medicine, University of Adelaide, Adelaide, South Australia;Hunter Medical Research Institute, and Department of General Medicine, John Hunter Hospital, Newcastle, Australia;Research Centre for Gender, Health and Ageing, University of Newcastle, Newcastle, New South Wales, Australia;Centre for Clinical Epidemiology & Biostatistics, School of Medicine & Public Health, University of Newcastle, HMRI Building, Callaghan-2308 Newcastle, NSW, Australia;School of Health Sciences, University of Newcastle, Newcastle, Australia

关键词: Zinc;    Women &;    Australia;    Diabetes;   

Others  :  1085631
DOI  :  10.1186/1472-6823-13-40

 received in 2013-07-05, accepted in 2013-09-18,  发布年份 2013

【 摘 要 】

Background

Animal studies have shown that zinc intake has protective effects against type 2 diabetes, but few studies have been conducted to examine this relationship in humans. The aim of this study is to investigate if dietary zinc is associated with risk of type 2 diabetes in a longitudinal study of mid-age Australian women.

Methods

Data were collected from a cohort of women aged 45-50 years at baseline, participating in the Australian Longitudinal Study on Women’s Health. A validated food frequency questionnaire was used to assess dietary intake and other nutrients. Predictors of 6-year incidence of type 2 diabetes were examined using multivariable logistic regression.

Results

From 8921 participants, 333 incident cases of type 2 diabetes were identified over 6 years of follow-up. After adjustment for dietary and non-dietary factors, the highest quintile dietary zinc intake had almost half the odds of developing type 2 diabetes (OR = 0.50, 95% C.I. 0.32–0.77) compared with the lowest quintile. Similar findings were observed for the zinc/iron ratio; the highest quintile had half the odds of developing type 2 diabetes (OR = 0.50, 95% C.I 0.30-0.83) after multivariable adjustment of covariates.

Conclusions

Higher total dietary zinc intake and high zinc/iron ratio are associated with lower risk of type 2 diabetes in women. This finding is a positive step towards further research to determine if zinc supplementation may reduce the risk of developing type 2 diabetes.

【 授权许可】

   
2013 Vashum et al.; licensee BioMed Central Ltd.

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