Effects of vitamin D receptor polymorphisms on urolithiasis risk: a meta-analysis

BMC Medical Genetics

Hong Jiang¹  Wei Nie²  Pan Zhang¹ 

[1] Department of Nephrology, the First People’s Hospital of Jingzhou City, the First Hospital of Yangtze University, Jingzhou, Hubei Province 434000, China;Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

关键词: Meta-analysis;    Polymorphism;    Vitamin D receptor;    Urolithiasis;   

Others  :  1122612
DOI  :  10.1186/1471-2350-14-104

 received in 2013-05-14, accepted in 2013-09-24,  发布年份 2013

【 摘 要 】

Background

Several studies analyzed the associations of Vitamin D receptor (VDR) polymorphisms with urolithiasis risk in different ethnic groups. However, the results were inconclusive. To evaluate a more precise estimation of the relationship, a meta-analysis was performed.

Methods

Pubmed, EMBASE, Wanfang Database, China National Knowledge Infrastructure (CNKI) and Weipu Database were searched. Data were extracted independently by two investigators. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations.

Results

Twenty-three case–control studies were included in this meta-analysis. Significant associations between ApaI, BsmI, FokI, and TaqI polymorphisms and urolithiasis risk were observed. However, sensitivity analyses for BsmI and FokI polymorphisms indicated that the results were not reliable and credible. In addition, there was a significant association of the ApaI-TaqI haplotype with urolithiasis risk.

Conclusions

This meta-analysis suggested that ApaI and TaqI polymorphisms in VDR gene were associated with urolithiasis risk.

【 授权许可】

   
2013 Zhang et al.; licensee BioMed Central Ltd.

【 图 表 】

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