Associations of cardiovascular risk factors, carotid intima-media thickness and manifest atherosclerotic vascular disease with carpal tunnel syndrome

BMC Musculoskeletal Disorders

Eira Viikari-Juntura⁵  Helena Liira⁴  Jorma Viikari²  Leena Moilanen¹  Markku Heliövaara³  Rahman Shiri⁵ 

[1] Department of Medicine, Kuopio University Hospital, and University of Kuopio, Kuopio, Finland;Department of Medicine, University of Turku, and Turku University Hospital, Turku, Finland;Department of Health and Functional Capacity, National Institute for Health and Welfare, Helsinki, Finland;Kirkkonummi Health Centre, Kirkkonummi, Finland;Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland

关键词: wrist;    smoking;    obesity;    hypertension;    coronary artery disease;    carotid artery;    Atherosclerosis;   

Others  :  1158550
DOI  :  10.1186/1471-2474-12-80

 received in 2010-09-08, accepted in 2011-04-26,  发布年份 2011

【 摘 要 】

Background

The role of atherosclerosis in carpal tunnel syndrome (CTS) has not previously been addressed in population studies. The aim of this study was to investigate the associations of cardiovascular risk factors, carotid artery intima-media thickness (IMT), and clinical atherosclerotic diseases with CTS.

Methods

In this cross sectional study, the target population consisted of subjects aged 30 or over who had participated in the national Finnish Health Survey in 2000-2001. Of the 7977 eligible subjects, 6254 (78.4%) were included in our study. Carotid IMT was measured in a sub-sample of subjects aged 45 to 74 (N = 1353).

Results

Obesity (adjusted odds ratio (OR) 2.4, 95% confidence interval (CI) 1.1-5.4), high LDL cholesterol (OR 3.8, 95% CI 1.6-9.1 for >190 vs. <129 mg/dL), high triglycerides (OR 2.7, 95% CI 1.2-6.1 for >200 vs. <150 mg/dL), hypertension (OR 3.4, 95% CI 1.6-7.4) and cardiac arrhythmia (OR 10.2, 95% CI 2.7-38.4) were associated with CTS in subjects aged 30-44. In the age group of 60 years or over, coronary artery disease (OR 1.9, 95% CI 1.1-3.5), valvular heart disease (OR 2.3, 95% CI 1.0-5.0) and carotid IMT (1.4, 95% CI 0.9-2.1 for each 0.23 mm increase) were associated with CTS. Carotid IMT was associated with CTS only in subjects with hypertension or clinical atherosclerotic vascular disease, or in those who were exposed to physical workload factors.

Conclusions

Our findings suggest an association between CTS and cardiovascular risk factors in young people, and carotid IMT and clinical atherosclerotic vascular disease in older people. CTS may either be a manifestation of atherosclerosis, or both conditions may share similar risk factors.

【 授权许可】

   
2011 Shiri et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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