Epidemiological profile of Dupuytren’s disease in Taiwan (Ethnic Chinese): a nationwide population-based study

BMC Musculoskeletal Disorders

Chin-Chen Chu⁴  Jhi-Joung Wang³  Cheng Liu²  Kuan-Ting Chen³  Chung-Han Ho¹  Kuo-Feng Huang²  Chin-Choon Yeh² 

[1] Department of Hospital and Health Care Administration, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan;Division of Plastic Surgery, Department of Surgery, Chi-Mei Medical Center, Yong-Kang, Tainan, Taiwan;Department of Anesthesiology, Chi Mei Medical Center, 901 Zhonghua Road, Tainan 71004, Yongkang District, Taiwan;Department of Recreation and Health-Care Management, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan

关键词: Chinese;    Ethnic;    Epidemiology;    Dupuytren’s disease;   

Others  :  1121961
DOI  :  10.1186/s12891-015-0476-7

 received in 2014-08-18, accepted in 2015-01-22,  发布年份 2015

【 摘 要 】

Background

The epidemiologic profile of ethnic Chinese patients with Dupuytren’s disease is unknown. We therefore investigated the epidemiology of Dupuytren’s disease using Taiwan’s National Health Insurance Research Database.

Methods

Patients who filed claims for treatment for Dupuytren’s disease between January 2000 and December 2011 were identified in the database. Age- and gender-specific incidences were estimated by dividing the incidence number by population data.

Results

We identified 1,078 patients with Dupuytren’s disease (681 men, 397 women; male/female ratio: 1:1.72). The annual incidence rate ranged from 0.39-0.63/10⁵ for men and 0.14-0.44/10⁵ for women. A trend analysis revealed a rising trend in the annual incidence from 2001 to 2011 (p = 0.0199). The prevalence rate increased steadily from 0.46/10⁵ in 2000 to 4.52/10⁵ in 2011 (p = 0.0186). The mean age at onset was significantly higher in men than in women (60.7 ± 18.4 vs. 53.7 ± 15.5 years). Peak age at onset for men was 70–79 (28.1%) and for women was 50–59 (33.5%). Men > 60 years old had higher incidence rates than did women (incidence rate ratios: 2.0, 4.5, and 6.6 for those 60–69, 70–79, and ≥ 80, respectively). Hypertension (29.6%), diabetes mellitus (21.9%), hyperlipidemia (14.8%), ischemic heart disease (10.5%), and chronic obstructive pulmonary disease (8.0%) were the most common comorbidities.

Conclusions

The incidence and prevalence of Dupuytren’s disease and the male/female ratio were significantly lower in ethnic Chinese than in Western ethnic groups. Moreover, the age at onset was significantly lower in ethnic Chinese women. However, the incidences of three comorbidities (hypertension, diabetes mellitus, and hyperlipidemia) were similar to those in other ethnicities.

【 授权许可】

   
2015 Yeh et al.; licensee BioMed Central.

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