Chromobacterium haemolyticum-induced bacteremia in a healthy young man

BMC Infectious Diseases

Naoki Yahagi¹  Susumu Nakajima¹  Chiba Kazuki³  Tokiya Ishida²  Masashi Narita⁵  Yuko Ono⁴  Akinori Matsumoto²  Kazuaki Shinohara²  Ryota Inokuchi¹  Megumi Okada² 

[1] Department of Emergency and Critical Care Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655 Bunkyo-ku, Tokyo, Japan;Department of Emergency and Critical Care Medicine, Ohta Nishinouchi Hospital, 2-5-20 Nishinouchi, 963-8558 Koriyama, Fukushima, Japan;Department of Bacteriology, Fukushima Institute of Public Health, 16-6 Mitouchi, Houkida, Fukushima city, Fukushima, Japan;Department of Emergency and Critical Care Medical Center, Fukushima Medical University Hospital, 1 Hikariga-oka, 960-1295 Fukushima City, Japan;Department of Medicine, Ohta Nishinouchi Hospital, 2-5-20 Nishinouchi, 963-8558 Koriyama, Fukushima, Japan

关键词: Necrotizing fasciitis;    Cellulitis;    Sepsis;    Chromobacterium violaceum;    Chromobacterium haemolyticum;   

Others  :  1145891
DOI  :  10.1186/1471-2334-13-406

 received in 2013-04-03, accepted in 2013-08-28,  发布年份 2013

【 摘 要 】

Background

The genus Chromobacterium consists of 7 recognized species. Among those, only C. violaceum, commonly found in the soil and water of tropical and subtropical regions, has been shown to cause human infection. Although human infection is rare, C. violaceum can cause life-threatening sepsis, with metastatic abscesses, most frequently infecting those who are young and healthy.

Case presentation

We recently identified a case of severe bacteremia caused by Chromobacterium haemolyticum infection in a healthy young patient following trauma and exposure to river water, in Japan. The patient developed necrotizing fasciitis that was successfully treated with a fasciotomy and intravenous ciprofloxacin and gentamicin.

Conclusions

C. haemolyticum should be considered in the differential diagnosis of skin lesions that progressively worsen after trauma involving exposure to river or lake water, even in temperate regions. Second, early blood cultures for the isolation and identification of the causative organism were important for initiating proper antimicrobial therapy.

【 授权许可】

   
2013 Okada et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

【 参考文献 】

• [1]Lima-Bittencourt CI, Costa PS, Barbosa FA, Chartone-Souza E, Nascimento AM: Characterization of a Chromobacterium haemolyticum population from a natural tropical lake. Lett Appl Microbiol 2011, 52:642-650.
• [2]Soby SD, Gadagkar SR, Contreras C, Caruso FL: Chromobacterium vaccinii sp. nov. isolated from native and cultivated cranberry (Vaccinium macrocarpon Ait.) bogs and irrigation ponds. Int J Syst Evol Microbiol 2012, 63:1840-1846.
• [3]Yang CH, Li YH: Chromobacterium violaceum infection: a clinical review of an important but neglected infection. J Chin Med Assoc 2011, 74:435-441.
• [4]Sultan HY, Boyle AA, Sheppard N: Necrotising fasciitis. BMJ 2012, 345:e4274.
• [5]Han XY, Han FS, Segal J: Chromobacterium haemolyticum sp. nov., a strongly haemolytic species. Int J Syst Evol Microbiol 2008, 58:1398-1403.
• [6]Mandell G, Bennett J, Dolin R: Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 7th Edition. Philadelphia: Churchill Livingston; 2010.
• [7]Campbell JI, Lan NP, Qui PT, Dung LT, Farrar JJ, Baker S: A successful antimicrobial regime for Chromobacterium violaceum induced bacteremia. BMC Infect Dis 2013, 13:4. BioMed Central Full Text
• [8]Aldridge KE, Valainis GT, Sanders CV: Comparison of the in vitro activity of ciprofloxacin and 24 other antimicrobial agents against clinical strains of Chromobacterium violaceum. Diagn Microbiol Infect Dis 1988, 10:31-39.
• [9]De Siqueira IC, Dias J, Ruf H, Ramos EA, Maciel EA, Rolim A, Labur L, Vasconcelos L, Silvany C: Chromobacterium violaceum in siblings, Brazil. Emerg Infect Dis 2005, 11:1443-1445.
• [10]Seigel JK, Stadler ME, Lombrano JL, Almony JS, Couch ME, Belhorn TH: Chromobacterium violaceum necrotizing fasciitis: A case report and review of the literature. Ear Nose Throat J 2012, 91:479-483.
• [11]Chattopadhyay A, Kumar V, Bhat N, Rao P: Chromobacterium violaceum infection: A rare but frequently fatal disease. J Pediatr Surg 2002, 37:108-110.