Associations of fetuin-A and osteoprotegerin with arterial stiffness and early atherosclerosis in chronic hemodialysis patients

BMC Nephrology

Dimitrios Memmos²  Georgios Efstratiadis²  Stella Douma¹  Aikaterini Papagianni²  Panagiotis Pateinakis² 

[1] 2nd Propedeutic and Department of Internal Medicine, Aristotle University of Thessaloniki, “Hippokration” General Hospital, Thessaloniki, Greece;Department of Nephrology, Aristotle University of Thessaloniki, “Hippokration” General Hospital, Thessaloniki, Greece

关键词: Pulse wave velocity;    Osteoprotegerin;    Hemodialysis;    Fetuin-A;    Intima-media thickness;   

Others  :  1082917
DOI  :  10.1186/1471-2369-14-122

 received in 2013-01-29, accepted in 2013-06-04,  发布年份 2013

【 摘 要 】

Background

Cardiovascular morbidity and mortality remains excessive in patients with chronic kidney disease. The association of vascular changes with regulators of extraosseous calcification in this patient population is still under investigation. The aim of the present study was to investigate the associations of the calcification inhibitor fetuin-A, and the anti-osteoclastic factor osteoprotegerin (OPG) with vascular pathology in chronic hemodialysis patients.

Methods

In this cross-sectional study including 81 stable chronic hemodialysis patients, we measured carotid-to-femoral pulse wave velocity (cfPWV) with applanation tonometry, reflecting arterial stiffness, and common carotid intima-media thickness (ccIMT), a surrogate of early atherosclerosis, as well as serum levels of fetuin-A and OPG. Co-morbidities, traditional cardiovascular risk factors, inflammatory markers and mineral-bone disease serology parameters were also recorded.

Results

cfPWV correlated inversely with fetuin-A (r=−0.355, p=0.001) and positively with OPG (r=0.584, p<0.001). In multilinear regression analysis including age, gender, diabetes, cardiovascular disease, hypertension, pulse pressure, LDL, logCRP, both fetuin-A and OPG were independently associated with cfPWV (p=0.024 and p=0.041 respectively). ccIMT was negatively associated with fetuin-A (r=−0.312, p=0.005) and positively with OPG (r=0.521, p<0.0001); however these associations lost statistical significance after adjustment for age.

Conclusion

In chronic hemodialysis patients both fetuin-A and OPG levels are independently associated with arterial stiffness but not with early atherosclerotic vascular changes.

【 授权许可】

   
2013 Pateinakis et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

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