Internet-delivered cognitive control training as a preventive intervention for remitted depressed patients: Protocol for a randomized controlled trial

BMC Psychiatry

Ernst H. W. Koster¹  Jeffrey Behiels¹  Lien Faelens¹  Kristof Hoorelbeke¹ 

[1] Department of Experimental Clinical and Health Psychology, Ghent University, Henri Dunantlaan 2, Ghent, B-9000, Belgium

关键词: Randomized controlled trial;    Relapse prevention;    Remitted depressed;    Depression;    Rumination;    Training;    Cognitive control;   

Others  :  1217022
DOI  :  10.1186/s12888-015-0511-0

 received in 2015-04-07, accepted in 2015-05-28,  发布年份 2015

【 摘 要 】

Background

Preventing recurrence of depression forms an important challenge for current treatments. Cognitive control impairments often remain present during remission of depression, putting remitted depressed patients at heightened risk for new depressive episodes by disrupting emotion regulation processes. Importantly, research indicates that cognitive control training targeting working memory functioning shows potential in reducing maladaptive emotion regulation and depressive symptomatology in clinically depressed patients and at-risk student samples. The current study aims to test the effectiveness of cognitive control training as a preventive intervention in a remitted depressed sample, exploring effects of cognitive control training on rumination and depressive symptomatology, along with indicators of adaptive emotion regulation and functioning.

Methods/design

We present a double blind randomized controlled design. Remitted depressed adults will complete 10 online sessions of a cognitive control training targeting working memory functioning or a low cognitive load training (active control condition) over a period of 14 days. Effects of training on primary outcome measures of rumination and depressive symptomatology will be assessed pre-post training and at three months follow-up, along with secondary outcome measure adaptive emotion regulation. Long-term effects of cognitive control training on broader indicators of functioning will be assessed at three months follow-up (secondary outcome measures).

Discussion

This study will provide information about the effectiveness of cognitive control training for remitted depressed adults in reducing vulnerability for depression. Furthermore, this study will address key questions concerning the mechanisms underlying the effects of cognitive control training, will take into account the subjective experience of the patients (including a self-report measure for cognitive functioning), and explore whether these effects extend to broad measures of functioning such as Quality of Life and disability.

Trial registration

This study is registered with ClinicalTrials.Gov, number NCT02407652 webcite.

【 授权许可】

   
2015 Hoorelbeke et al.

【 图 表 】

Fig. 1.

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