Left atrial volume index and aortic stiffness index in adult hemodialysed patients - link between compliance and pressure mediated by endothelium dysfunction; a cross-sectional study

BMC Cardiovascular Disorders

Andrzej Jaroszyński¹  Andrzej Książek²  Andrzej Wysokiński³  Tomasz Zapolski³ 

[1]Chair and Department of Family Medicine, Medical University of Lublin, Lublin, Poland

[2]Chair and Department of Nephrology, Medical University of Lublin, Lublin, Poland

[3]Chair and Department of Cardiology, Medical University of Lublin, Lublin, Poland

关键词: Hemodialysis;    End-stage renal disease;    Asymmetric dimethylarginine;    NT-pro BNP;    Aortic stiffness;    Left atrium volume index;   

Others  :  1084542
DOI  :  10.1186/1471-2261-12-100

 received in 2012-06-11, accepted in 2012-10-19,  发布年份 2012

【 摘 要 】

Background

This study was performed to investigate the relationship between elastic properties of aorta and left atrium volume index (LAVI) in hemodialyzed (HD) patients.

Methods

Study group was consisted of 73 patients (age 51,6 ± 7,6 years) treated by hemodialysis. In all patients standard echocardiography was performed. Aortic stiffness index (ASI) was calculated using formula: ASI = log (SBP/DBP)/[(Aomax-Aomin)/Aomin]. LAVI was calculated according to the formula: LAVI = [π/6 x (LAmax x LAshort x LAlong)]/m². Additionally several indices were calculated: left ventricle mass (LVM), left ventricle mass index (LVMI), midwall fractional shortening (mFS), endsystolic stress (ESS), mFS/ESS. Additionally the laboratory parameters including lipidogram, troponin T (cTnT), NT-proBNP and asymmetric dimethylarginine (ADMA) were measured.

Results

The ASI was strong and significantly correlated with left atrium volume (LAV) and LAVI (respectively: 0,601;p < 0,001 and 0,598; p < 0,001). The ASI was independently and markedly associated with ADMA, cTnT, CRP, T-chol,and LDL-chol. The LAVI was independently and significantly correlated with NT-proBNP and cTnT.

Conclusions

There is correlation between ASI and ADMA, marker of endothelium dysfunction. There is also association between LAVI and NT-proBNP, signs of elevated left atrium pressure. The strong correlation between ASI and LAVI, improved by associations of specific biochemical markers with these echocardiographic indices, suggests there is the link between elastic properties of aorta and left atrium pressure in hemodialysed patients mediated by endothelial dysfunction.

【 授权许可】

   
2012 Zapolski et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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