Circulating microparticles: square the circle

BMC Cell Biology

Ivan A Vorobjev⁵  Larry Duckett⁷  Eugeny D Ponomarev⁶  Joel NH Stern³  Michael Bernimoulin⁴  Elizaveta Fasler-Kan²  Natasha S Barteneva¹ 

[1] Department of Pediatrics, Harvard Medical School, Boston, MA, USA;Department of Biomedicine, University Hospital Basel, Basel, Switzerland;Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA;Division of Hematology, University Hospital, Geneva, Switzerland;A.N. Belozersky Institute for Physico-Chemical Biology and Department of Cell Biology, Biological Faculty, M.V. Lomonosov Moscow State University, Moscow, Russia;Thematic Research Program for Neurodegeneration, Development and Repair, School for Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong;BD Biosciences Inc, San Jose, CA, USA

关键词: Therapy;    Diagnostics;    Disease;    Microvesicles;    Exosomes;    Microparticles;    Circulating;   

Others  :  855340
DOI  :  10.1186/1471-2121-14-23

 received in 2012-11-05, accepted in 2013-03-20,  发布年份 2013

【 摘 要 】

Background

The present review summarizes current knowledge about microparticles (MPs) and provides a systematic overview of last 20 years of research on circulating MPs, with particular focus on their clinical relevance.

Results

MPs are a heterogeneous population of cell-derived vesicles, with sizes ranging between 50 and 1000 nm. MPs are capable of transferring peptides, proteins, lipid components, microRNA, mRNA, and DNA from one cell to another without direct cell-to-cell contact. Growing evidence suggests that MPs present in peripheral blood and body fluids contribute to the development and progression of cancer, and are of pathophysiological relevance for autoimmune, inflammatory, infectious, cardiovascular, hematological, and other diseases. MPs have large diagnostic potential as biomarkers; however, due to current technological limitations in purification of MPs and an absence of standardized methods of MP detection, challenges remain in validating the potential of MPs as a non-invasive and early diagnostic platform.

Conclusions

Improvements in the effective deciphering of MP molecular signatures will be critical not only for diagnostics, but also for the evaluation of treatment regimens and predicting disease outcomes.

【 授权许可】

   
2013 Barteneva et al.; licensee BioMed Central Ltd.

【 图 表 】

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