Cetaceans evolution: insights from the genome sequences of common minke whales

BMC Genomics

Heebal Kim⁵  Seoae Cho⁵  David W Burt⁴  Yuseob Kim¹  Sunjin Moon⁸  Young-Jun Kwon²  Hyeon Jeong Kim⁵  Woori Kwak⁵  Jaemin Kim⁵  Young Sub Lee²  Dong Hyun Shin⁹  Won Cheoul Park⁹  Kyu-Won Kim²  Taeheon Lee⁹  Bo-Young Lee⁹  Sook Hee Yoon⁹  Myung Hum Park⁷  Myunghee Joung^1,11  Hojin Jung^1,11  Du-Hae An⁶  Eun Mi Kim³  Jung-Ha Kang³  Hye Suck An³  Chul-Min An³  Naohisa Kanda^1,10  Yong-Rock An⁶  Jung Youn Park³ 

[1] Department of Life Science, Ewha Womans University, Seoul, Korea;Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 151-742, Republic of Korea;Biotechnology Research Division, National Fisheries Research & Development Institute, Gijang gun, Busan 619-705, Republic of Korea;The Roslin Institute, University of Edinburgh, Midlothian EH25 9GR, UK;C&K Genomics, Seoul National University Research Park, Seoul 151-919, Republic of Korea;Cetacean Research Institute, National Fisheries Research & Development Institute, Nam-gu, Ulsan 680-050, Republic of Korea;TNT Research, #924 Doosan Venture Digm, Anyang 431-755, Gyeonggi-do, Republic of Korea;Department of Genome Sciences, University of Washington, Seattle 98195-5065, WA, USA;Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Republic of Korea;The Institute of Cetacean Research, Toyomi 4-5, Chuo-ku 104-0055, Tokyo, Japan;Codes division, Insilicogen,Inc., Suwon 441-813, Gyeonggi-do, Republic of Korea

关键词: Genome;    Positive selection;    Common minke whale;    Cetaceans;   

Others  :  1118201
DOI  :  10.1186/s12864-015-1213-1

 received in 2014-01-10, accepted in 2015-01-02,  发布年份 2015

【 摘 要 】

Background

Whales have captivated the human imagination for millennia. These incredible cetaceans are the only mammals that have adapted to life in the open oceans and have been a source of human food, fuel and tools around the globe. The transition from land to water has led to various aquatic specializations related to hairless skin and ability to regulate their body temperature in cold water.

Results

We present four common minke whale (Balaenoptera acutorostrata) genomes with depth of ×13 ~ ×17 coverage and perform resequencing technology without a reference sequence. Our results indicated the time to the most recent common ancestors of common minke whales to be about 2.3574 (95% HPD, 1.1521 – 3.9212) million years ago. Further, we found that genes associated with epilation and tooth-development showed signatures of positive selection, supporting the morphological uniqueness of whales.

Conclusions

This whole-genome sequencing offers a chance to better understand the evolutionary journey of one of the largest mammals on earth.

【 授权许可】

   
2015 Park et al.; licensee Biomed Central.

【 图 表 】

Figure 1.

Figure 2.

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