Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites

BMC Complementary and Alternative Medicine

In Koo Hwang²  Yeo Sung Yoon²  Youn-Gil Kwak³  Jung Hoon Choi¹  Jong Whi Kim²  Sung Min Nam²  Woosuk Kim²  Dae Young Yoo²  Hyo Young Jung² 

[1] Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon 200-701, South Korea;Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, South Korea;Central Research Center, Natural F&P Co. Ltd, Cheongwon 363-883, South Korea

关键词: Amygdala;    Hippocampus;    Norepinephrine;    Serotonin;    Psychological stress;    Physical stress;    Valeriana officinalis;   

Others  :  1085067
DOI  :  10.1186/1472-6882-14-476

 received in 2014-04-11, accepted in 2014-09-22,  发布年份 2014

【 摘 要 】

Background

In this study, we investigate the effects of valerian root extracts (VE) on physical and psychological stress responses by utilizing a communication box.

Methods

Eight-week-old ICR mice received oral administration of VE (100 mg/kg/0.5 ml) or equal volume of distilled water in every day for 3 weeks prior to being subjected to physical or psychological stress for 3 days, which are induced by communication box developed for physical electric shock and psychological stress by nociceptive stimulation-evoked responses. The stress condition was assessed by forced swimming test and serum corticosterone levels. In addition, norepinephrine (NE), serotonin (5-HT), and their metabolites such as 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO₄) and 5-hydroxyindoleacetic acid (5-HIAA) were measured in the hippocampus and amygdala at 1 h after final stress condition, respectively.

Results

Immobility time and corticosterone levels were significantly increased in both the physical and psychological stress groups compared to the control group. The administration of VE significantly reduced these parameters in both the physical and psychological stress groups. In addition, compared to the control group, physical and psychological stress groups showed significantly increased levels of MHPG-SO₄ and 5-HIAA in the hippocampus and amygdala, respectively. The administration of VE significantly suppressed the increase of MHPG-SO₄ and 5-HIAA in the two stress groups.

Conclusion

These results suggest that VE can suppress physical and psychological stress responses by modulating the changes in 5-HT and NE turnover in the hippocampus and amygdala.

【 授权许可】

   
2014 Jung et al.; licensee BioMed Central.

【 图 表 】

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