Cardiovascular fitness associated with cognitive performance in heart failure patients enrolled in cardiac rehabilitation

BMC Cardiovascular Disorders

John Gunstad¹  Morgan L Oberle³  Jim Rosneck¹  Joel Hughes¹  Richard Josephson³  Lawrence Sweet²  Naftali Raz⁴  Ronald Cohen²  Mary Beth Spitznagel¹  Michael L Alosco⁵  Sarah Garcia⁵ 

[1] Summa Health System, Akron, OH, USA;Brown University, Providence, RI, USA;Department of Medicine, Case Western Reserve University School of Medicine, Harrington Heart & Vascular Institute, University Hospitals Case Medical Center, Cleveland, OH, USA;Wayne State University, Detroit, MI, USA;Department of Psychology, Kent State University, Kent, OH, 44242, USA

关键词: Metabolic equivalents task;    Cardiac rehabilitation;    Heart failure;   

Others  :  857732
DOI  :  10.1186/1471-2261-13-29

 received in 2013-01-08, accepted in 2013-04-08,  发布年份 2013

【 摘 要 】

Background

Reduced cognitive function is common in persons with heart failure (HF). Cardiovascular fitness is a known contributor to cognitive function in many patient populations, but has only been linked to cognition based on estimates of fitness in HF. The current study examined the relationship between fitness as measured by metabolic equivalents (METs) from a standardized stress test and cognition in persons with HF, as well as the validity of office-based predictors of fitness in this population.

Methods

Forty-one HF patients enrolled in cardiac rehabilitation completed a standardized exercise stress test protocol, a brief neuropsychological battery, the 2-minute step test (2MST), and a series of medical history and self-report questionnaires.

Results

Maximum METs from stress testing demonstrated incremental predictive validity for attention (β = .41, p = .03), executive function (β = .37, p = .04), and memory domains (β = .46, p = .04). Partial correlations accounting for key medical and demographic characteristics revealed greater METs was associated with the 2MST (r (32) = .41, p = .02) but not with the Duke Activity Status Index (DASI) (r(32) = .24, p = .17).

Conclusion

The current findings indicate that better fitness levels measured by METs is independently associated with better cognitive function in older adults with HF. Results also showed that METs was closely associated with one office-based measure of fitness (2MST), but not another (DASI). Prospective studies are needed to clarify the mechanisms linking fitness and cognitive function in HF.

【 授权许可】

   
2013 Garcia et al.; licensee BioMed Central Ltd.

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