| BMC Health Services Research | |
| Drug waste minimization as an effective strategy of cost-containment in Oncology | |
| Manuela Miscoria2  Mauro Mansutti1  Alessandro Follador1  Luisa Marini3  Giuseppe Aprile1  Gianpiero Fasola1  | |
| [1] Oncology Department, University Hospital of Udine, 33100 Udine, Italy;Oncology Department, University Hospital of Trieste, 34100 Trieste, Italy;Pharmacy Department, University Hospital of Udine, Udine 33100, Italy | |
| 关键词: Drug waste; Oncology; Cost-containment; | |
| Others : 1134142 DOI : 10.1186/1472-6963-14-57 |
|
| received in 2013-06-15, accepted in 2014-01-29, 发布年份 2014 | |
PDF
|
|
【 摘 要 】
Background
Sustainability of cancer care is a crucial issue for health care systems worldwide, even more during a time of economic recession. Low-cost measures are highly desirable to contain and reduce expenditures without impairing the quality of care. In this paper we aim to demonstrate the efficacy of drug waste minimization in reducing drug-related costs and its importance as a structural measure in health care management.
Methods
We first recorded intravenous cancer drugs prescription and amount of drug waste at the Oncology Department of Udine, Italy. Than we developed and applied a protocol for drug waste minimization based on per-pathology/per-drug scheduling of chemotherapies and pre-planned rounding of dosages.
Results
Before the protocol, drug wastage accounted for 8,3% of the Department annual drug expenditure. Over 70% of these costs were attributable to six drugs (cetuximab, docetaxel, gemcitabine, oxaliplatin, pemetrexed and trastuzumab) that we named ‘hot drugs’. Since the protocol introduction, we observed a 45% reduction in the drug waste expenditure. This benefit was confirmed in the following years and drug waste minimazion was able to limit the impact of new pricely drugs on the Department expenditures.
Conclusions
Facing current budgetary constraints, the application of a drug waste minimization model is effective in drug cost containment and may produce durable benefits.
【 授权许可】
2014 Fasola et al.; licensee BioMed Central Ltd.
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| 20150305092029423.pdf | 364KB | ||
| Figure 5. | 35KB | Image | |
| Figure 4. | 29KB | Image | |
| Figure 3. | 28KB | Image | |
| Figure 2. | 19KB | Image | |
| Figure 1. | 23KB | Image |
【 图 表 】
Figure 1.
Figure 2.
Figure 3.
Figure 4.
Figure 5.
【 参考文献 】
- [1]Sullivan R, Peppercorn J, Sikora K, et al.: Delivering affordable cancer care in high-income countries. Lancet Oncol 2011, 12:933-980.
- [2]Pearson SD: Cost, coverage, and comparative effectiveness research: the critical issues for oncology. J Clin Oncol 2012, 30:4275-4281.
- [3]Meropol NJ, Schrag D, Smith TJ, et al.: American Society of Clinical Oncology Statement: the cost of cancer care. J Clin Oncol 2009, 27:3868-3874.
- [4]Berry SR, Bell CM, Uber PA, et al.: Continental Divide? The attitudes of US and Canadian oncologists on the costs, cost-effectiveness, and health policies associated with new cancer drugs. J Clin Oncol 2010, 28:4149-4153.
- [5]Nierengarten MB: Cost of care: Tough issues facing oncology. Lancet Oncol 2008, 9:420.
- [6]Khayat D: Innovative cancer therapies: putting costs into context. Cancer 2012, 118:2367-2371.
- [7]Hoffman JM, Shah ND, Vermeulen LC, et al.: Projecting future drug expenditures 2009. Am J Health Syst Pharm. 2009, 66:237-257.
- [8]Bach PB: Costs of cancer care: A view from the Centers for Medicare and Medicaid Services. J Clin Oncol 2007, 25:187-190.
- [9]Fasola G, Aprile G, Aita M: A Model to Estimate Human Resource Needs for the Treatment of Outpatients With Cancer. J Oncol Pract 2012, 1:13-17.
- [10]Hoffman JM, Shah ND, Vermeulen LC, et al.: Projecting future drug expenditures 2008. Am J Health Syst Pharm 2008, 65:234-253.
- [11]Pearson SA, Ringland CL, Ward RL: Trastuzumab and metastatic breast cancer: trastuzumab use in Australia–monitoring the effect of an expensive medicine access program. J Clin Oncol 2007, 25:3688-3693.
- [12]Bach PB: Limits on medicare’s ability to control rising spending on cancer drugs. N Engl J Med 2009, 360:626-633.
- [13]Fojo T, Noonan A, Grady C: How much is life worth: the multibillion dollar question in contemporary oncology. Educational ASCO 2011.
- [14]Lopes Gde L Jr, de Souza JA, Barrios C: Access to cancer medications in low and middle-income countries. Nat Rev Clin Oncol 2013, 10:22-314.
- [15]Chávarri-Guerra Y, Villarreal-Garza C, Liedke PE, et al.: Breast cancer in Mexico: a growing challenge to health and the health system. Lancet Oncol 2012, 13:e335-e343.
- [16]Cheema PK, Gavura S, Migus M, et al.: International variability in the reimbursement of cancer drugs by publically funded drug programs. Curr Oncol 2012, 19:e165-e176.
- [17]Nava-Ocampo AA, Alarcón-Almanza JM, Moyao-García D, et al.: Undocumented drug utilization and drug waste increase costs of pediatric anesthaesia care. Fundam Clin Pharmacol 2004, 18:107-112.
- [18]Dooley MJ, Singh S, Michael M: Implications of dose rounding of chemotherapy to the nearest vial size. Support Care Cancer 2004, 12:653-656.
- [19]Fasola G, Aita M, Marini L, et al.: Drug waste minimization and cost-containment in Medical Oncology: two-years results of a feasibility study. BMC Health Serv Res 2008, 8:70. doi: 10.1186/1472-6963-8-70 BioMed Central Full Text
- [20]Smith TJ, Hillner BE: Bending the cost curve in cancer care. N Engl J Med 2011, 364:2060-2065.
- [21]Field K: Dose rounding of chemotherapy in colorectal cancer: an analysis of clinician attitudes and the potential impact on treatment costs. Asia Pac J Clin Oncol 2010, 6:203-209.
- [22]Elkin EB, Bach PB: Cancer's next frontier: addressing high and increasing costs. JAMA 2010, 303:1086-1087.
- [23]Caplan AL: Will evidence ever be sufficient to resolve the challenge of cost containment? J Clin Oncol 2011, 29:1946-1948.
- [24]Cornes P: The economic pressures for biosimilar drug use in cancer medicine. Targ Oncol 2012, 7:S57-S67.
- [25]Renner L, Nkansah FA, Dodoo AN: The role of generic medicines and biosimilars in oncology in low-income countries. Ann Oncol 2013, 24(Suppl 5):v29-v32.
- [26]Jarkowski A, Nestico JS, Vona KL, Khushalani NI: Dose rounding of ipilimumab in adult metastatic melanoma patients results in significant cost savings. J Oncol Pharm Pract 2013. [Epub ahead of print]
- [27]Winger BJ, Clements EA, DeYoung JL, et al.: Cost savings from dose rounding of biologic anticancer agents in adults. J Oncol Pharm Practice 2010, 17:246-251.
- [28]Ebos JML, Lee CR, Kerbel RS: Tumour and host-mediated pathways of resistance and disease progression in response to antiangiogenic therapy. Clin Cancer Res 2009, 15:5020-5025.
- [29]Rudnick SI, Adams GP: Affinity and avidity in antibody based tumor targeting. Cancer Biother Radiopharmaceut 2009, 24:155-161.
PDF