BMC Clinical Pharmacology | |
Antibiotic sales in rural and urban pharmacies in northern Vietnam: an observational study | |
Heiman FL Wertheim1  Nguyen Van Kinh2  Nguyen Van Yen7  Peter Horby1  Ho Dang Phuc5  Tran Khanh Toan6  Hoang Thi Loan6  Nguyen Thi Thuy Nguyen6  Nguyen Quynh Hoa3  Nguyen Phuong Hoa6  Nguyen Thi Kim Chuc6  Do Thi Thuy Nga4  | |
[1] Nuffield Department of Clinical Medicine, Centre for Tropical Diseases, Oxford, UK;National Hospital for Tropical Diseases, Hanoi, Vietnam;Vietnam National Cancer Hospital, Hanoi, Vietnam;Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Hanoi, Vietnam;Department of Probability and Statistics, Institute of Mathematics, VAST, Hanoi, Vietnam;Hanoi Medical University, Hanoi, Vietnam;Hanoi Department of Health, Hanoi, Vietnam | |
关键词: Pharmacy; Vietnam; Practice; Community; Prescription; Dispensing; Antibiotic; | |
Others : 860418 DOI : 10.1186/2050-6511-15-6 |
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received in 2013-03-27, accepted in 2014-01-29, 发布年份 2014 | |
【 摘 要 】
Background
The irrational overuse of antibiotics should be minimized as it drives the development of antibiotic resistance, but changing these practices is challenging. A better understanding is needed of practices and economic incentives for antibiotic dispensing in order to design effective interventions to reduce inappropriate antibiotic use. Here we report on both quantitative and qualitative aspects of antibiotic sales in private pharmacies in northern Vietnam.
Method
A cross-sectional study was conducted in which all drug sales were observed and recorded for three consecutive days at thirty private pharmacies, 15 urban and 15 rural, in the Hanoi region in 2010. The proportion of antibiotics to total drug sales was assessed and the revenue was calculated for rural and urban settings. Pharmacists and drug sellers were interviewed by a semi-structured questionnaire and in-depth interviews to understand the incentive structure of antibiotic dispensing.
Results
In total 2953 drug sale transactions (2083 urban and 870 rural) were observed. Antibiotics contributed 24% and 18% to the total revenue of pharmacies in urban and rural, respectively. Most antibiotics were sold without a prescription: 88% in urban and 91% in rural pharmacies. The most frequent reported reason for buying antibiotics was cough in the urban setting (32%) and fever in the rural area (22%). Consumers commonly requested antibiotics without having a prescription: 50% in urban and 28% in rural area. The qualitative data revealed that drug sellers and customer’s knowledge of antibiotics and antibiotic resistance were low, particularly in rural area.
Conclusion
Over the counter sales of antibiotic without a prescription remains a major problem in Vietnam. Suggested areas of improvement are enforcement of regulations and pricing policies and educational programs to increase the knowledge of drug sellers as well as to increase community awareness to reduce demand-side pressure for drug sellers to dispense antibiotics inappropriately.
【 授权许可】
2014 Nga et al.; licensee BioMed Central Ltd.
【 预 览 】
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20140724183421699.pdf | 316KB | download | |
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【 参考文献 】
- [1]World Health Organization Report: WHO Global Strategy for Containment Resistance to Antimicrobial Drugs. Geneva: WHO report, WHO/CDS/CSR/DRS/2001.2; 2001.
- [2]Barbosa TM, Levy SB: The impact of antibiotic use on resistance development and persistence. Drug Resist Update 2000, 3:303-311.
- [3]Tilak JD-M: Bacterial resistance to antibiotics: a growing public health problem. McMaster Univ Med J 2011, 8:58-61.
- [4]Bi P, Tong S, Parton KA: Family self-medication and antibiotics abuse for children and juveniles in a Chinese city. Soc Sci Med 2000, 50(10):1445-1450.
- [5]Llor C, Cots JM: The sale of antibiotics without prescription in pharmacies in Catalonia Spain. Clin Infect Dis 2009, 48(10):1345-1349.
- [6]World Health Organization: Medicines Use in Primary Care in Developing and Transitional Countries. Geneva: World Health Organization; 2009. [WHO Fact Book WHO/EMP/MAR/2009.3]
- [7]Landers TF, Ferng YH, McLoughlin JW, Barrett AE, Larson E: Antibiotic identification, use, and self-medication for respiratory illnesses among urban Latinos. J Am Acad Nurse Pract 2010, 22(9):488-495.
- [8]Hoa NQ, Larson M, Kim Chuc NT, Eriksson B, Trung NV, Stalsby CL: Antibiotics and paediatric acute respiratory infections in rural Vietnam: health-care providers' knowledge, practical competence and reported practice. Trop Med Int Health 2009, 14(5):546-555.
- [9]Okumura J, Wakai S, Umenai T: Drug utilisation and self-medication in rural communities in Vietnam. Soc Sci Med 2002, 54(12):1875-1886.
- [10]Thuan NT, Lofgren C, Lindholm L, Chuc NT: Choice of healthcare provider following reform in Vietnam. BMC Health Serv Res 2008, 8:162. BioMed Central Full Text
- [11]Vietnam Ministry of Health: Vietnam Ministry of Health Decision No 1847/2003/QD-BYT about Regulation of Drug Prescribing and Selling Prescription Only. Hanoi, Vietnam: Vietnam Ministry of Health; 2003.
- [12]Larsson M, Kronvall G, Chuc NT, Karlsson I, Lager F, Hanh HD, Tomson G, Falkenberg T: Antibiotic medication and bacterial resistance to antibiotics: a survey of children in a Vietnamese community. Trop Med Int Health 2000, 5(10):711-721.
- [13]Larsson M: Antibiotic Use and Resistance: Assessing and Improving Utilization and Provision of Antibiotics and Other Drugs in Vietnam. Sweden: Karolinska Institutet; 2003. [PhD Thesis]
- [14]Chuc NT, Diwan V: FilaBavi, a demographic surveillance site, an epidemiological field laboratory in Vietnam. Scand J Public Health Suppl 2003, 62:3-7.
- [15]Tran TK, Eriksson B, Nguyen CT, Horby P, Bondjers G, Petzold M: DodaLab: an urban health and demographic surveillance site, the first three years in Hanoi. Vietnam. Scand J Public Health 2012, 40(8):765-772.
- [16]Hoa NQ: High Antibiotic Use and Resistance among Children Under Five. Sweden: Department of Public Health Sciences, Karolinska Institutet; 2010. [PhD Thesis]
- [17]Graneheim UH, Lundman B: Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. Nurse Educ Today 2004, 24(2):105-112.
- [18]Nyazema N, Viberg N, Khoza S, Vyas S, Kumaranayake L, Tomson G, Lundborg CS: Low sale of antibiotics without prescription: a cross-sectional study in Zimbabwean private pharmacies. J Antimicrob Chemother 2007, 59(4):718-726.
- [19]Al-Faham Z, Habboub G, Takriti F: The sale of antibiotics without prescription in pharmacies in Damascus. Syria. J Infect Dev Ctries 2011, 5(5):396-399.
- [20]Bin Abdulhak AA, Altannir MA, Almansor MA, Almohaya MS, Onazi AS, Marei MA, Aldossary OF, Obeidat SA, Obeidat MA, Riaz MS, Tleyjeh IM: Non prescribed sale of antibiotics in Riyadh. Saudi Arabia: a cross sectional study. BMC Public Health 2011, 11:538. BioMed Central Full Text
- [21]Salunkhe SD, Pandit VA, Dawane JS, Sarda KD, More CS: Study of over the counter sale of antimicrobials in pharmacy outlets in Pune, India: a cross sectional study. Int J Pharm Bio Sci 2013, 4(2):616-622.
- [22]Werner K, Deasy J: Acute respiratory tract infections: when are antibiotics indicated? JAAPA 2009, 22(4):22-26.
- [23]Arroll B, Kenealy T, Falloon K: Are antibiotics indicated as an initial treatment for patients with acute upper respiratory tract infections? A review. N Z Med J 2008, 121(1284):64-70.
- [24]Bavestrello L, Cabello A, Casanova D: Impact of regulatory measures in the trends of community consumption of antibiotics in Chile. Revista medica de Chile 2002, 130(11):1265-1272.
- [25]Park S, Soumerai SB, Adams AS, Finkelstein JA, Jang S, Degnan DR: Antibiotic use following a Korean national policy to prohibit medication dispensing by physicians. Health Policy Plann 2005, 20(5):302-309.
- [26]Nguyen KV, FL H, Wertheim & Group: Situation Analysis: Antibiotic Use and Resistance in Vietnam. Hanoi, Vietnam: GARP Vietnam; 2010. [Report from the GARP Vietnam National Working Group]
- [27]Yi Wen EL, Dai W, Yuanhao Hong & Group: A qualitative study about self-medication in the community among market vendors in Fuzhou. China. Health Soc Care Community 2011, 19:504-513.
- [28]Chandra S, DS B: Evaluating medicines dispensing patterns at private community pharmacies in Tamilnadu, India. Southern Med Rev 2010, 3:27-31.
- [29]Vietnam Government Office: Vietnam Government Decree No 79/2006/NĐ-CP on Implementing some articles of Drug Law. Hanoi, Vietnam: Vietnam Government Office; 2006.
- [30]World Health Organization Report: Medicines Prices: Make People Sicker and Poorer. Hanoi, Vietnam; 2011. [WHO Report, Country Office] [http://apps.who.int/medicinedocs/documents/s19220en/s19220en.pdf webcite]
- [31]Huttner B, Goossens H, Verheij T, Harbarth S: Characteristics and outcomes of public campaigns aimed at improving the use of antibiotics in out-patients in high-income contries. Lancet Infect Dis 2010, 10:17-31.