Characteristics of pyogenic odontogenic infection in patients attending Mulago Hospital, Uganda: a cross-sectional study

BMC Microbiology

Charles Mugisha Rwenyonyi³  Henry Kajumbula²  Arabat Kasangaki³  Louis Muwaz³  Richard Kityamuwesi¹ 

[1] Department of Oral and Maxillofacial Surgery, Mulago Hospital, Kampala, Uganda;Department of Microbiology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda;Department of Dentistry, School of Health Sciences, College of Health Sciences, Makerere University, Kampala, Uganda

关键词: Susceptibility;    Odontogenic infection;    HIV;    Bacterial isolates;    Antibiotics;   

Others  :  1137361
DOI  :  10.1186/s12866-015-0382-z

 received in 2014-07-15, accepted in 2015-02-11,  发布年份 2015

【 摘 要 】

Background

Predisposing factors of pyogenic odontogenic infection include dental caries, pericoronitis, periodontitis, trauma to the dentition and the supporting structures or complications of dental procedures. The infections are usually polymicrobial involving normal endogenous flora. We characterised pyogenic odontogenic infection in patients attending Mulago Hospital, Uganda.

Results

Of the 130 patients, 62 (47.7%) were female. The most frequently involved fascial spaces were: the buccal, 52 (25.4%); submasseteric, 46 (22.4%) and the submandibular space, 36 (17.5%). Dental caries was the most prevalent predisposing factor, particularly of the lower third molar teeth. Viridans Streptococci Group and Staphylococcus aureus were the most frequent bacterial isolates: 23.5% and 19.4%, respectively. All Viridans Streptococci isolates were resistant to penicillin G, sulfamethoxazole/trimethoprim (cotrimoxazole), ampicillin and tetracycline, but susceptible to vancomycin. All Staphylococcus aureus strains were resistant to cotrimoxazole and ampicillin while retaining susceptibility to vancomycin, cefotaxime, linezolid, moxifloxacin and amoxicillin/clavulanate. Thirty five (26.9%) patients were HIV infected and the HIV status did not significantly influence the pattern of odontogenic infection.

Conclusions

Dental caries was the most prevalent predisposing factor for pyogenic odontogenic infection. High prevalence of bacterial resistance to ampicillin and cotrimoxazole suggests the need for regular antibiotic susceptibility tests of isolates and rational use of antibiotics in the management of these infections. Prevention requires strengthening of oral health in the community.

【 授权许可】

   
2015 Kityamuwesi et al.; licensee BioMed Central.

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