Expression of histone deacetylases 1, 2 and 3 in urothelial bladder cancer

BMC Clinical Pathology

Glen Kristiansen²  Peter J Wild³  Holger Moch³  Tullio Sulser⁴  Martin Schmidtpeter⁴  Hans-Helge Seifert¹  Daniel Schweckendiek⁴  Thomas Hermanns⁴  Bastian Jentsch³  Cédric Poyet⁴ 

[1] Department of Urology, Hegau-Bodensee Hospital, Singen, Germany;Institute of Pathology, University of Bonn, Sigmund-Freud-Str. 25, Bonn D-53127, Germany;Institute of Pathology, University of Zürich, Zürich, Switzerland;Department of Urology, University of Zürich, Zürich, Switzerland

关键词: Molecular markers;    Urothelial cancer;    Class I HDACs;   

Others  :  821479
DOI  :  10.1186/1472-6890-14-10

 received in 2013-07-22, accepted in 2014-03-10,  发布年份 2014

【 摘 要 】

Background

Histone deacetylases (HDACs) are known to be associated with an overexpression in different types of cancer such as colon and prostate cancer. In this study we aimed to evaluate the protein expression of class I HDACs in urothelial carcinoma of the bladder.

Methods

A tissue microarray containing 348 tissuesamples from 174 patients with a primary urothelial carcinoma of the bladder was immunohistochemically stained for HDAC 1, 2 and 3. Intensity of staining was evaluated and the association with clinico-pathological features and prognosis was assessed.

Results

High HDAC expression levels were found in 40 to 60% of all investigated urothelial carcinomas (HDAC-1: 40%, HDAC-2: 42%, HDAC-3: 59%).

HDAC-1 and HDAC-2 were significantly associated with higher tumour grades.

Although all three markers could not predict progression in univariate analyses, high HDAC-1 expression was associated with a trend toward poorer prognosis. Patients with high-grade tumours and high expression levels of HDAC-1 were more likely to progress compared to all other patients (p < 0.05).

Conclusions

High-grade noninvasive papillary bladder tumours are associated with high expression levels of HDAC-1 and HDAC-2. High grade tumours in combination with high expression of HDAC-1 showed a worse prognosis than the other tumours. The high expression levels of HDACs observed particularly in high grade urothelial bladder cancer clearly warrant subsequent studies on the potential use of HDAC inhibitors as a novel therapeutic approach.

【 授权许可】

   
2014 Poyet et al.; licensee BioMed Central Ltd.

【 图 表 】

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