期刊论文详细信息
BMC Research Notes
Candida albicans lumbar spondylodiscitis in an intravenous drug user: a case report
Hua-Cheng Yen2  Wei Liang Chen1  Chang-Hua Chen3 
[1] Department of Medical Imaging, Changhua Christian Hospital, Changhua, Taiwan;Department of Neurosurgery, Changhua Christian Hospital, Changhua, Taiwan;College of Medicine & Nursing, Hung Kuang University, Taichung, Taiwan
关键词: Fungal infection;    Vertebral osteomyelitis;    Spine;    Lumbar spondylodiscitis;    Candida albicans;   
Others  :  1140498
DOI  :  10.1186/1756-0500-6-529
 received in 2013-08-30, accepted in 2013-12-04,  发布年份 2013
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【 摘 要 】

Background

Spondylodiscitis leads to debility, and few data exist on Candida spondylodiscitis in patients with intravenous drug use.

Case presentation

We present a case of Candida albicans lumbar spondylodiscitis in a patient with intravenous drug use. This patient was treated with surgical debridement and 9 months of fluconazole therapy, and the neurological deficits resolved completely. The infection did not recur clinically or radiologically during 9 months of follow-up.

Conclusion

Although Candida albicans lumbar spondylodiscitis is rare, Candida should be suspected as a causative pathogen in patients with intravenous drug use except for Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis. As soon as Candida albicans lumbar spondylodiscitis is suspected, magnetic resonance imaging and percutaneous biopsy should be performed. Surgical intervention combined with treatment with antifungal medications can successfully eradicate the infection and resolve the neurological deficits.

【 授权许可】

   
2013 Chen et al.; licensee BioMed Central Ltd.

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【 参考文献 】
  • [1]Acosta FL Jr, Chin CT, Quiñones-Hinojosa A, Ames CP, Weinstein PR, Chou D: Diagnosis and management of adult pyogenic osteomyelitis of the cervical spine. Neurosurg Focus 2004, 17:E2.
  • [2]Butler JS, Shelly MJ, Timlin M, Powderly WG, O'Byrne JM: Nontuberculous pyogenic spinal infection in adults: a 12-year experience from a tertiary referral center. Spine 2006, 31:2695-2700.
  • [3]Acosta FL Jr, Dowd CF, Chin C, Tihan T, Ames CP, Weinstein PR: Current treatment strategies and outcomes in the management of symptomatic vertebral hemangiomas. Neurosurgery 2006, 58:287-295.
  • [4]Cottle L, Riordan T: Infectious spondylodiscitis. J Infect 2008, 56:401-412.
  • [5]O'Daly BJ, Morris SF, O'Rourke SK: Long-term functional outcome in pyogenic spinal infection. Spine 2008, 33:E246-E253.
  • [6]Connor CL: Monilia from osteomyelitis. J Infect Dis 1928, 43:108-116.
  • [7]Waldvogel FA, Medoff G, Swartz MN: Osteomyelitis: a review of clinical features, therapeutic consideration, and unusual aspects. N Engl J Med 1970, 282:198-206.
  • [8]Gathe JC, Harris RL, Garland B, Bradshaw MW, Williams TW: Candida osteomyelitis: report of five cases and review of literature. Am J Med 1987, 82:927-937.
  • [9]Aboltins CA, Allen P, Daffy JR: Fungal endophthalmitis in intravenous drug users injecting buprenorphine contaminated with oral Candida species. Med J Aust 2005, 182:427.
  • [10]Daas H, Abuhmaid F, Zervos M: Successful treatment of Candida parapsilosis and Pseudomonas aeruginosa infection using medical and surgical management in an injecting drug user with mitral and aortic valve endocarditis: a case report. J Med Case Rep 2009, 3:6598.
  • [11]Westling K, Thalme A, Julander I: Candida albicans tricuspid valve endocarditis in an intravenous drug addict: successful treatment with fluconazole. Scand J Infect Dis 2005, 37:310-311.
  • [12]Edwards JE, Turkel SB, Elder HA, Rand RW, Guze LB: Haematogenous Candida osteomyelitis: report of three cases and review of literature. Am J Med 1975, 59:89-94.
  • [13]Wang YC, Lee ST: Candida vertebral osteomyelitis: a case report and review of the literature. Chang Gung Med J 2001, 24:810-815.
  • [14]Hirschmann JV, Everett ED: Candida vertebral osteomyelitis: case report and review of literature. J Bone Joint Surg 1976, 58:573-575.
  • [15]Park SW, Jeong JH, Choi SH, Kim YS, Woo JH, Jeon SR: Candidal spondylitis: five new cases and a review of previously reported cases. Korean J Spine 2007, 4:31-36.
  • [16]Almekinders LC, Greene WB: Vertebral Candida infections: a case report and review of the literature. Clin Orthop 1991, 267:174-178.
  • [17]Burns J, Hemker T, Dahmen G: Fungal spondylitis. Acta Orthop Scand 1986, 57:563-565.
  • [18]Dietze DD Jr, Fessler RG, Jacob RP: Primary reconstruction for spinal infections. J Neurosurg 1997, 86:981-989.
  • [19]Owen PG, Willis BK, Benzel EC: Torulopsis glabrata vertebral osteomyelitis. J Spinal Disord 1992, 5:370-373.
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