期刊论文详细信息
BMC Psychiatry
Neural mechanisms of subclinical depressive symptoms in women: a pilot functional brain imaging study
Gabriel S Dichter2  Christopher Petty2  Joshua Bizzell2  Joseph McClernon2  Brett Froeliger3  Rachel V Kozink3  Moria J Smoski3  Jennifer N Felder1 
[1] Department of Psychology and Neuroscience, University of Colorado Boulder, UCB 345, Boulder, CO, 80309-0345, USA;Duke-UNC Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, USA;Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
关键词: Reward;    Resting state;    Emotion regulation;    Depression symptoms;    FMRI;   
Others  :  1124279
DOI  :  10.1186/1471-244X-12-152
 received in 2012-01-05, accepted in 2012-08-24,  发布年份 2012
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【 摘 要 】

Background

Studies of individuals who do not meet criteria for major depressive disorder (MDD) but with subclinical levels of depressive symptoms may aid in the identification of neurofunctional abnormalities that possibly precede and predict the development of MDD. The purpose of this study was to evaluate relations between subclinical levels of depressive symptoms and neural activation patterns during tasks previously shown to differentiate individuals with and without MDD.

Methods

Functional magnetic resonance imaging (fMRI) was used to assess neural activations during active emotion regulation, a resting state scan, and reward processing. Participants were twelve females with a range of depressive symptoms who did not meet criteria for MDD.

Results

Increased depressive symptom severity predicted (1) decreased left midfrontal gyrus activation during reappraisal of sad stimuli; (2) increased right midfrontal gyrus activation during distraction from sad stimuli; (3) increased functional connectivity between a precuneus seed region and left orbitofrontal cortex during a resting state scan; and (4) increased paracingulate activation during non-win outcomes during a reward-processing task.

Conclusions

These pilot data shed light on relations between subclinical levels of depressive symptoms in the absence of a formal MDD diagnosis and neural activation patterns. Future studies will be needed to test the utility of these activation patterns for predicting MDD onset in at-risk samples.

【 授权许可】

   
2012 Felder et al.; licensee BioMed Central Ltd.

【 预 览 】
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