Y chromosome of the inbred mouse KK/Ta strain is associated with reduced body size in Y-consomic strains

BMC Research Notes

Jun-ichi Suto¹ 

[1]Agrogenomics Research Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8634, Japan

关键词: Y chromosome;    Dh;    Consomic mice;    Body size;    Body weight;    Body length;    A^y allele;   

Others  :  1143474
DOI  :  10.1186/1756-0500-6-64

 received in 2013-01-07, accepted in 2013-02-11,  发布年份 2013

【 摘 要 】

Background

We have established 17 Y chromosome consomic (Y-consomic) mouse strains in an inbred DH/Sgn strain. In this study, based on investigations in four different genetic backgrounds, we proved that the Y chromosome of the inbred mouse KK/Ta strain is associated with reduced body size.

Findings

In the DH-Chr Y-+/+ background, Y chromosome substitution significantly decreased the body weight in DH-Chr Y^KK-+/+ and DH-Chr Y^SJL-+/+ strains, and the DH-Chr Y^KK-+/+ strain was the lightest among the 17 Y-consomic strains. In the DH-Chr Y-Dh/+ background (Dh/+ mice have skeletal malformations and are usually lighter than +/+ mice), although Y chromosome substitution did not significantly alter the body weight, the DH-Chr Y^KK-Dh/+ strain was the lightest among the 17 Y-consomic-Dh/+ strains. In the (B6.Cg-A^y × DH-Chr Y) F₁-+/+ background, Y chromosome substitution significantly decreased the body weight and length in the (B6.Cg-A^y × DH-Chr Y^KK) F₁ hybrids. In the (B6.Cg-A^y × DH-Chr Y) F₁-A^y/+ background (A^y causes obesity and promotes linear growth), Y chromosome substitution significantly decreased body weight and length in the (B6.Cg-A^y × DH-Chr Y^KK) F₁-A^y/+ hybrids.

Conclusion

A body-size-reducing effect of the Y chromosome of the KK/Ta mouse strain was observed irrespective of genetic background. The effect was observed in the presence of Dh and A^y, the autosomal dominant mutations, both of which are known to have substantial effects on body size. These results suggest that there are Y-linked genes that control the body size in mice.

【 授权许可】

   
2013 Suto; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 1.

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