Establishing reference intervals for electrolytes in newborns and infants using direct ISE analyzer

BMC Research Notes

Samuel Kinde³  Tilahun Teka³  Paulos Nigussie²  Mahilet Yigeremu³  Mulugeta Melkie¹ 

[1] Department of Medical Laboratory Science, Arbaminch University, Arbaminch, Ethiopia;Ethiopian Health and Nutrition Research Institute, Addis Ababa, Ethiopia;Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia

关键词: Direct ISE;    Cord blood;    Infants;    Newborns;    Robust method;    Electrolytes;    Reference intervals;   

Others  :  1142646
DOI  :  10.1186/1756-0500-6-199

 received in 2012-09-25, accepted in 2013-05-15,  发布年份 2013

【 摘 要 】

Background

To generate clinically applicable reference intervals (RIs) for commonly requested electrolytes in Ethiopian newborns and infants that can help in early detection, close monitoring and correction of electrolyte abnormalities. Cord blood (from newborns, n = 60) and venous blood samples (from infants, n = 57) were collected and analyzed using direct ISE analyzer, AVL (9181). MedCalc® software was applied to determine the robust upper and lower end points covering 95% of the reference values of each electrolyte with respective 90% CIs.

Findings

This is an extension report of our recent study; and hence is resulted from the same data source. The level of Na⁺ and K⁺ showed difference in newborns and infants even though combined RIs were suggested by the Haris and Boyd rule as 126–143 mmol/l and 4.0-7.9 mmol/l respectively. However, Cl^- values failed to show such a difference and thus a combined RI was determined to be 100–111 mmol/l. Almost all maternal, neonatal and infantile factors were not able to affect the values of the electrolytes.

Conclusion

Combined RIs are suggested for the interpretation of electrolyte values in newborns and infants without taking the effect of maternal, neonatal and infantile factors into account. Since the RIs were different from previously reported values, it will be appropriate to apply such RIs for the interpretation of electrolyte values in Ethiopian pediatric population.

【 授权许可】

   
2013 Melkie et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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