Serum vitamin D status in children with protein-energy malnutrition admitted to a national referral hospital in Uganda

BMC Research Notes

Sarah Kiguli¹  Agnes N. Kiragga³  Reuben K. Kiggundu²  Josephine Kasolo²  Henry W. Nabeta² 

[1] Department of Pediatrics and Child Health, College of Health Sciences, Makerere University, Kampala, Uganda;Department of Physiology, College of Health Sciences, Makerere University, Kampala, Uganda;Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda

关键词: Uganda;    Children;    Malnutrition;    Vitamin D;   

Others  :  1230313
DOI  :  10.1186/s13104-015-1395-2

 received in 2015-02-28, accepted in 2015-08-31,  发布年份 2015

【 摘 要 】

Background

Vitamin D deficiency is a world-wide epidemic with recent estimates indicating that greater than 50 % of the global population is at risk. In Uganda, 80 % of healthy community children in a survey were found to be vitamin D insufficient. Protein-energy malnutrition is likely to be associated with vitamin D intake deficiency. The aim of this study was to determine the prevalence of vitamin D deficiency and the associated factors among children admitted with protein-energy malnutrition to the pediatrics wards of Mulago hospital in Kampala, Uganda.

Methods

Consecutive sampling was done with 158 children, aged 6–24 months, enrolled in a cross sectional study. One hundred and seventeen malnourished and 41 non malnourished children were enrolled from the Acute Care unit, pediatrics in-patient wards, outpatient and immunization clinics, following informed consent obtained from the children’s parents/guardians. Children with protein energy malnutrition were categorized based on anthropometric measurements of weight-for-height and weight for length compared with the recommended WHO reference Z-score. Serum 25-hydroxyvitamin D, calcium and phosphate were assayed.

Results

One hundred seventeen malnourished and 41 non malnourished children were enrolled. The majority of study participants were male, 91 (57.6 %). The mean serum vitamin D levels among the malnourished was 32.5 mmol/L (±12.0 SD) and 32.2 mmol/L (10.9 SD) among the malnourished, p = 0.868. Fifteen (36.6 %) of the non malnourished children and 51 (43.6 %) of the malnourished had suboptimal levels, p = 0.689. Malnourished children admitted with meningitis and cerebral palsy had lower serum vitamin D levels than those with other infections.

Conclusion

There was no statistically significant difference in vitamin D values between the malnourished and non malnourished children. Clinicians should actively screen for children for serum vitamin D levels regardless of nutritional status.

【 授权许可】

   
2015 Nabeta et al.

【 图 表 】

Fig.1.

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