Estimation of genetic parameters and detection of quantitative trait loci for minerals in Danish Holstein and Danish Jersey milk

BMC Genetics

Jakob Sehested³  Lotte B Larsen²  Nina A Poulsen²  Bart Buitenhuis¹ 

[1] Aarhus University, Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Blichers Allé 20, Tjele, DK-8830, Denmark;Aarhus University, Department of Food Science, Blichers Allé 20, Tjele, DK-8830, Denmark;Aarhus University, Department of Animal Science, Blichers Allé 20, Tjele, DK-8830, Denmark

关键词: Association study;    Genetic parameters;    Element;    Minerals;    Bovine milk;   

Others  :  1216024
DOI  :  10.1186/s12863-015-0209-9

 received in 2015-02-27, accepted in 2015-04-27,  发布年份 2015

【 摘 要 】

Background

Bovine milk provides important minerals, essential for human nutrition and dairy product quality. For changing the mineral composition of the milk to improve dietary needs in human nutrition and technological properties of milk, a thorough understanding of the genetics underlying milk mineral contents is important. Therefore the aim of this study was to 1) estimate the genetic parameters for individual minerals in Danish Holstein (DH) (n = 371) and Danish Jersey (DJ) (n = 321) milk, and 2) detect genomic regions associated with mineral content in the milk using a genome-wide association study (GWAS) approach.

Results

For DH, high heritabilities were found for Ca (0.72), Zn (0.49), and P (0.46), while for DJ, high heritabilities were found for Ca (0.63), Zn (0.57), and Mg (0.57). Furthermore, intermediate heritabilities were found for Cu in DH, and for K, Na, P and Se in the DJ. The GWAS revealed a total of 649 significant SNP markers detected for Ca (24), Cu (90), Fe (111), Mn (3), Na (1), P (4), Se (12) and Zn (404) in DH, while for DJ, a total of 787 significant SNP markers were detected for Ca (44), Fe (43), K (498), Na (4), Mg (1), P (94) and Zn (3). Comparing the list of significant markers between DH and DJ revealed that the SNP ARS-BFGL-NGS-4939 was common in both breeds for Zn. This SNP marker is closely linked to the DGAT1 gene. Even though we found significant SNP markers on BTA14 in both DH and DJ for Ca, and Fe these significant SNPs did not overlap.

Conclusion

The results show that Ca, Zn, P and Mg show high heritabilities. In combination with the GWAS results this opens up possibilities to select for specific minerals in bovine milk.

【 授权许可】

   
2015 Buitenhuis et al.; licensee BioMed Central.

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