The risk of upper gastrointestinal bleeding in patients treated with hemodialysis: a population-based cohort study

BMC Nephrology

Chun-Yuh Yang¹  Chien-Te Lee³  I-Ming Lee⁴  Hsin-Wei Kuo²  Chien-Chun Kuo³ 

[1] Division of Environmental Health and Occupational Medicine, National Health Research Institute, Miaoli, Taiwan;Division of Nephrology, Department of Internal Medicine, Yuan’s General Hospital, Kaohsiung, Taiwan;Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Kaohsiung, Taiwan;Department of Public Health, Kaohsiung Medical University, 100 Shih-Chuan 1st RD, Kaohsiung 80708, Taiwan

关键词: Cohort study;    End-stage renal disease;    Upper gastrointestinal bleeding;   

Others  :  1083023
DOI  :  10.1186/1471-2369-14-15

 received in 2012-07-01, accepted in 2013-01-14,  发布年份 2013

【 摘 要 】

Background

There are no prior studies that have estimated the risk of upper gastrointestinal bleeding (UGIB) among the dialysis population relative to the general population. The aim of this study was to examine the risk of UGIB among end-stage renal disease (ESRD) patients during a 6-year period following their initiation of hemodialysis (HD) therapy in Taiwan- a country with the highest incidence of ESRD in the world, using general population as an external comparison group.

Methods

Data were obtained from the Taiwan National health Insurance Research Database. In total, 796 patients who were beginning HD between 1999 and 2003 were recruited as the study cohort and 3,184 patients matched for age and sex were included as comparison cohort. Multivariate Cox proportional hazard regression models were used to adjust for confounding and to compare the 6-year UGIB-free survival rate between these two cohorts.

Results

The incidence rate of UGIB (42.01 per 1000 person-year) was significantly higher in the HD cohort than in the control cohort (27.39 per 1000 person-years). After adjusting for potential confounders, the adjusted hazard ratios for UGIB during the 6-year follow-up periods for HD patients was 1.27 (95% CI=1.03-1.57) compared to patients in the comparison cohort.

Conclusions

We conclude that HD patients were at an increased risk for UGIB compared with the general population.

【 授权许可】

   
2013 Kuo et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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