Dysphonia as a sign of HPV laryngeal infection: a case report

BMC Research Notes

Dennis de Carvalho Ferreira⁵  Renata Quintella Zamolyi³  Alcina Frederica Nicol¹  Nathalia Silva Oliveira¹  Carla Renata Petillo de Pinho⁴  Fernanda Sampaio Cavalcante⁶  Helena Lucia Barroso dos Reis²  Carlos Eduardo Gama Longubuco⁷ 

[1]Laboratory of Interdisciplinary Medical Research (LIPMED), Oswaldo Cruz Foundation -Fiocruz, Rio de Janeiro, Brazil

[2]Ginecology and Obstetrics Outpatient Care, Federal University of Espírito Santo (UFES), Vitória, Brazil

[3]Pathology Anatomy Service, Bonsucesso Federal Hospital, Rio de Janeiro, Brazil

[4]Oral Medicine Area, School of Dentistry, Veiga de Almeida University, Rio de Janeiro, Brazil

[5]Abeu University Center, Belford Roxo, Rio de Janeiro, Brazil

[6]Paulo de Goes Microbiology Institute - Medical Microbiology Department, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

[7]Biologic Science Undergraduate Program - Microbiology Program, Salgado de Oliveira University, Rio de Janeiro, Brazil

关键词: Vocal fold;    Human papillomavirus;    Dysphonia;   

Others  :  1092301
DOI  :  10.1186/1756-0500-7-898

 received in 2014-09-21, accepted in 2014-11-18,  发布年份 2014

【 摘 要 】

Background

Voice dysfunction or dysphonia may be associated with several clinical conditions. Among these, laryngeal human papillomavirus (HPV)-induced lesions should be considered as a possible causative factor. We report a case of dysphonia in a patient presenting with an HPV laryngeal lesion. We also discuss the clinical features of the disease, its histopathological findings, and treatment and rigorous follow-up.

Case presentation

We report a case of laryngeal papilloma in a 29-year-old, Afro-descendant, male patient with dysphonia. He was a non-smoker and was not a drug user. Videolaryngostroboscopy revealed signs suggestive of pharyngolaryngeal reflux. The right vocal fold presented with a papillomatous aspect in the posterior third, which underwent excision. Histopathological examination showed a nodular lesion of the right vocal fold, conclusive of squamous papilloma with absence of malignancy.

Conclusion

Patients presenting with persistent voice dysfunction or dysphonia should be investigated for possible laryngeal HPV infection. Diagnostic confirmation by HPV genotyping is important for follow-up of potential recurrence.

【 授权许可】

   
2014 Longubuco et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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