Risk factors for latent tuberculosis infection in close contacts of active tuberculosis patients in South Korea: a prospective cohort study

BMC Infectious Diseases

Dick Menzies³  Hee Jin Kim⁴  Young Sil Hwang⁵  Jang Rak Kim²  Jong Deog Lee⁵  Ho Cheol Kim⁵  Yi Yeong Jeong⁵  Yu Ji Cho⁵  You Eun Kim¹  Seung Hun Lee¹  Seung Jun Lee¹ 

[1] Department of Internal Medicine, College of Medicine, Gyeongsang National University, 90 Chilam-Dong, Jinju, Gyeongnam 660-302, South Korea;Department of Preventive Medicine, College of Medicine, Gyeongsang National University, Jinju, South Korea;Montreal Chest Institute, McGill University, Montreal, Canada;Korean Institute of Tuberculosis, Seoul, South Korea;Gyeongsang Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea

关键词: Tuberculosis, pulmonary;    Independent living;    Latent tuberculosis;    Interferon-gamma release tests;    Tuberculin test;   

Others  :  1122023
DOI  :  10.1186/s12879-014-0566-4

 received in 2013-07-02, accepted in 2014-10-16,  发布年份 2014

【 摘 要 】

Background

The diagnosis and treatment of latent tuberculosis infection (LTBI) have become mandatory to reduce the burden of tuberculosis worldwide. Close contacts of active TB patients are at high risk of both active and LTBI. The aim of this study is to identify the predominant risk factors of contracting LTBI, persons in close contact with TB patients were recruited. This study also aimed to compare the efficacy of the tuberculin skin test (TST) and QuantiFERON®-TB GOLD (QFT-G) to diagnose LTBI.

Methods

Close contacts of active pulmonary TB patients visiting a hospital in South Korea were diagnosed for LTBI using TST and/or QFT-G. The association of positive TST and/or QFT-G with the following factors was estimated: age, gender, history of Bacillius Calmette-Guerin (BCG) vaccination, history of pulmonary TB, cohabitation status, the acid-fast bacilli smear status, and presence of cough in source cases.

Results

Of 308 subjects, 38.0% (116/305) were TST positive and 28.6% (59/206) were QFT-G positive. TST positivity was significantly associated with male gender (OR: 1.734; 95% CI: 1.001-3.003, p =0.049), history of pulmonary TB (OR: 4.130; 95% CI: 1.441-11.835, p =0.008) and household contact (OR: 2.130; 95% CI: 1.198-3.786, p =0.01) after adjustment for confounding variables. The degree of concordance between TST and QFT-G was fair (70.4%, κ =0.392).

Conclusions

A prevalence of LTBI among close contacts of active pulmonary TB patients was high, and prior TB history and being a household contact were risk factors of LTBI in the study population.

【 授权许可】

   
2014 Lee et al.; licensee BioMed Central Ltd.

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