A randomised controlled trial comparing opt-in and opt-out home visits for tracing lost participants in a prospective birth cohort study

BMC Medical Research Methodology

Kate Tilling²  Lynn Molloy¹  John Macleod²  Kirsty Burston³  Rachel Williams³  Ross Robinson¹  Joanne Malcolm¹  Pei Hayes⁴  Lindsey Brown⁴  Andy Boyd¹  Sian Noble²  Isabelle Bray⁵ 

[1] ALSPAC, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK;School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK;Ipsos MORI, 79-81 Borough Road, London SE1 1FY, UK;The Ethox Centre, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK;Department of Health and Social Science, University of the West of England, Frenchay Campus, Bristol BS16 1QY, UK

关键词: Cost-effectiveness;    Acceptability;    Cohort study;    Participation;    Tracking;    Tracing;    Consent;    Opt-out;    Opt-in;   

Others  :  1221110
DOI  :  10.1186/s12874-015-0041-y

 received in 2014-12-19, accepted in 2015-06-03,  发布年份 2015

【 摘 要 】

Background

Attrition is an important problem in cohort studies. Tracing cohort members who have moved or otherwise lost contact with the study is vital. There is some debate about the acceptability and relative effectiveness of opt-in versus opt-out methods of contacting cohort members to re-engage them in this context. We conducted a randomised controlled trial to compare the two approaches in terms of effectiveness (tracing to confirm address and consenting to continue in the study), cost-effectiveness and acceptability.

Methods

Participants in this trial were individuals (young people and mothers) recruited to the Avon Longitudinal Study of Parents and Children (ALSPAC), who had not engaged with the study in the previous 5 years and for whom mail had been returned from their last known address. The sampling frame was restricted to those for whom database searching led to a potential new address being found in the Bristol area. 300 participants were randomly selected and assigned using stratified randomisation to the opt-in or opt-out arm. A tailored letter was sent to the potential new address, either asking participants to opt in to a home visit, or giving them the option to opt out of a home visit. Fieldworkers from Ipsos MORI conducted home visits to confirm address details.

Results

The proportion who were traced was higher in the opt-out arm (77/150 = 51 %) than the opt-in arm (6/150 = 4 %), as was the proportion who consented to continue in ALSPAC (46/150 = 31 % v 4/150 = 3 %). The mean cost per participant was £8.14 in the opt-in arm and £71.93 in the opt-out arm. There was no evidence of a difference in acceptability between the opt-in and opt-out approaches.

Conclusion

Since the opt-in approach yielded very low response rates, and there were no differences in terms of acceptability, we conclude that the opt-out approach is the most effective method of tracing disengaged study members. The gains made in contacting participants must be weighed against the increase in cost using this methodology.

【 授权许可】

   
2015 Bray et al.

【 图 表 】

Fig. 1.

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