Comparative safety of serotonin (5-HT 3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis

BMC Medicine

Sharon E Straus¹  David Moher²  Brenda R Hemmelgarn⁴  Brian Hutton²  Kelly Mrklas⁴  Jesmin Antony⁵  Carmen Ng⁵  Joanne Ho⁵  Reid Robson⁵  Emily Reynen⁵  Heather MacDonald⁵  Huda Ashoor⁵  Lisa Strifler⁵  John Ivory⁵  Afshin Vafaei⁵  Paul A Khan⁵  Areti A Veroniki⁵  Erik Blondal⁵  Charlene Soobiah³  Andrea C Tricco⁶ 

[1] Department of Geriatric Medicine, University of Toronto, 27 King’s College Circle, Toronto M5S 1A1, ON, Canada;Clinical Epidemiology Program, Centre for Practice-Changing Research, Ottawa Hospital Research Institute, 725 Parkdale Ave, Ottawa K1Y 4E9, ON, Canada;Institute for Health Policy Management and Evaluation, University of Toronto, 4th Floor, 155 College St, Toronto M5T 3M6, ON, Canada;Departments of Community Health Sciences, Faculty of Medicine, University of Calgary, TRW Building, 3rd Floor, 3280 Hospital Drive, Calgary T2N 4Z6, AB, Canada;Li Ka Shing Knowledge Institute, St. Michael’s Hospital, 209 Victoria Street, East Building, Toronto M5B 1W8, ON, Canada;Epidemiology Division, Dalla Lana School of Public Health, University of Toronto, 6th floor, 155 College St, Toronto M5T 3M7, ON, Canada

关键词: Postoperative vomiting;    Postoperative nausea;    Serotonin receptor antagonists;    Network meta-analysis;    Systematic review;   

Others  :  1216036
DOI  :  10.1186/s12916-015-0379-3

 received in 2014-11-26, accepted in 2015-05-19,  发布年份 2015

【 摘 要 】

Background

Serotonin (5-HT ₃ ) receptor antagonists are commonly used to decrease nausea and vomiting for surgery patients, but these agents may be harmful. We conducted a systematic review on the comparative safety of 5-HT ₃receptor antagonists.

Methods

Searches were done in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials to identify studies comparing 5-HT ₃receptor antagonists with each other, placebo, and/or other antiemetic agents for patients undergoing surgical procedures. Screening search results, data abstraction, and risk of bias assessment were conducted by two reviewers independently. Random-effects pairwise meta-analysis and network meta-analysis (NMA) were conducted. PROSPERO registry number: CRD42013003564.

Results

Overall, 120 studies and 27,787 patients were included after screening of 7,608 citations and 1,014 full-text articles. Significantly more patients receiving granisetron plus dexamethasone experienced an arrhythmia relative to placebo (odds ratio (OR) 2.96, 95 % confidence interval (CI) 1.11–7.94), ondansetron (OR 3.23, 95 % CI 1.17–8.95), dolasetron (OR 4.37, 95 % CI 1.51–12.62), tropisetron (OR 3.27, 95 % CI 1.02–10.43), and ondansetron plus dexamethasone (OR 5.75, 95 % CI 1.71–19.34) in a NMA including 31 randomized clinical trials (RCTs) and 6,623 patients of all ages. No statistically significant differences in delirium frequency were observed across all treatment comparisons in a NMA including 18 RCTs and 3,652 patients.

Conclusion

Granisetron plus dexamethasone increases the risk of arrhythmia.

【 授权许可】

   
2015 Tricco et al.

【 图 表 】

Figure 1.

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【 参考文献 】

• [1]Gan TJ, Meyer T, Apfel CC, Chung F, Davis PJ, Eubanks S et al.. Consensus guidelines for managing postoperative nausea and vomiting. Anesth Analg. 2003; 97:62-71.
• [2]McCracken G, Houston P, Lefebvre G. Guideline for the management of postoperative nausea and vomiting. J Obstet Gynaecol Can. 2008; 30:600-7.
• [3]Constenla M. 5-HT3 receptor antagonists for prevention of late acute-onset emesis. Ann Pharmacother. 2004; 38:1683-91.
• [4]Buyukavci M, Olgun H, Ceviz N. The effects of ondansetron and granisetron on electrocardiography in children receiving chemotherapy for acute leukemia. Am J Clin Oncol. 2005; 28:201-4.
• [5]Pinarli FG, Elli M, Dagdemir A, Baysal K, Acar S. Electrocardiographic findings after 5-HT3 receptor antagonists and chemotherapy in children with cancer. Pediatr Blood Cancer. 2006; 47:567-71.
• [6]Gagnon ML. Moving knowledge to action through dissemination and exchange. J Clin Epidemiol. 2011; 64:25-31.
• [7]Tricco AC, Soobiah C, Antony J, Hemmelgarn B, Moher D, Hutton B et al.. Safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery and chemotherapy: protocol for a systematic review and network meta-analysis. Syst Rev. 2013; 2:46.
• [8]Tricco AC, Soobiah C, Blondal E, Veroniki AA, Khan PA, Vafaei A et al. Comparative efficacy of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis. BMC Med. 2015; Ahead of print.
• [9]Carlisle JB. The analysis of 168 randomised controlled trials to test data integrity. Anaesthesia. 2012; 67:521-37.
• [10]Gan TJ, Gu J, Singla N, Chung F, Pearman MH, Bergese SD et al.. Rolapitant for the prevention of postoperative nausea and vomiting: a prospective, double-blinded, placebo-controlled randomized trial. Anesth Analg. 2011; 112:804-12.
• [11]Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M et al.. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. University of Ottawa, Ottawa; 2014.
• [12]Glacy J, Putnam K, Godfrey S, Falzon L, Mauger B, Samson D, et al. Treatments for seasonal allergic rhinitis [Internet]. Rockville: Agency for Healthcare Research and Quality; 2013. (Comparative Effectiveness Reviews, No. 120.) Appendix F, McMaster Quality Assessment Scale of Harms (McHarm). http://www.ncbi.nlm.nih.gov/books/NBK153703/. Accessed Jan 2015.
• [13]Raudenbush SW. Analyzing effect sizes: Random-effects models. In: The handbook of research synthesis and meta-analysis. 2nd ed. Cooper H, Hedges LV, Valentine JC, editors. The Russell Sage Foundation, New York; 2009: p.295-316.
• [14]Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21:1539-58.
• [15]Viechtbauer W. Conducting meta-analyses in R with the metafor package. J Stat Softw. 2010; 36:1-48.
• [16]R Core Team. R: A language and environment for statistical computing. http://www.R-project.org/. Accessed: Jan 2015.
• [17]Salanti G. Indirect and mixed-treatment comparison, network, or multiple-treatments meta-analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool. Res Synth Meth. 2012; 3:80-97.
• [18]Chaimani A, Higgins JP, Mavridis D, Spyridonos P, Salanti G. Graphical tools for network meta-analysis in STATA. PLoS One. 2013; 8:e76654.
• [19]White IR, Barrett JK, Jackson D, Higgins J. Consistency and inconsistency in network meta‐analysis: model estimation using multivariate meta‐regression. Res Synth Meth. 2012; 3:111-25.
• [20]Song F, Altman DG, Glenny AM, Deeks JJ. Validity of indirect comparison for estimating efficacy of competing interventions: empirical evidence from published meta-analyses. BMJ. 2003; 326:472.
• [21]Veroniki AA, Vasiliadis HS, Higgins JP, Salanti G. Evaluation of inconsistency in networks of interventions. Int J Epidemiol. 2013; 42:332-45.
• [22]Salanti G, Ades AE, Ioannidis JPA. Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial. J Clin Epidemiol. 2011; 64:163-71.
• [23]Chen CC, Lin CS, Ko YP, Hung YC, Lao HC, Hsu YW. Premedication with mirtazapine reduces preoperative anxiety and postoperative nausea and vomiting. Anesth Analg. 2008; 106:109-13.
• [24]Omran HASA, Nasr DAM. Effect of premedication with mirtazapine versus ondansetron on postoperative nausea and vomiting in breast surgery. Egypt J Anaesth. 2011; 27:135-9.
• [25]Homesley HD, Hahne WF, McLees B, Heck K, Barrett RJ, Lentz SS et al.. Randomized comparison of the antiemetic efficacy of a serotonin type 3 receptor antagonist (MDL 72,222) with a high-dose metoclopramide regimen. Am J Clin Oncol. 1993; 16:175-9.
• [26]Gan TJ, Meyer TA, Apfel CC, Chung F, Davis PJ, Habib AS et al.. Society for Ambulatory Anesthesia guidelines for the management of postoperative nausea and vomiting. Anesth Analg. 2007; 105:1615-28.
• [27]Golembiewski J, Chernin E, Chopra T. Prevention and treatment of postoperative nausea and vomiting. Am J Health Syst Pharm. 2005; 62:1247-60.
• [28]Kovac AL. Prevention and treatment of postoperative nausea and vomiting. Drugs. 2000; 59:213-43.
• [29]Wilhelm SM, Dehoorne-Smith ML, Kale-Pradhan PB. Prevention of postoperative nausea and vomiting. Ann Pharmacother. 2007; 41(1):68-78.
• [30]Yun MJ, Kim YH, Kim AR. Comparison of azasetron and ondansetron for preventing postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgery. Yonsei Med J. 2010; 51:88-92.
• [31]Gunter JB, McAuliffe JJ, Beckman EC, Wittkugel EP, Spaeth JP, Varughese AM. A factorial study of ondansetron, metoclopramide, and dexamethasone for emesis prophylaxis after adenotonsillectomy in children. Paediatr Anaesth. 2006; 16:1153-65.
• [32]Gupta P, Khanna J, Mitramustafi AK, Bhartia VK. Role of pre-operative dexamethasone as prophylaxis for postoperative nausea and vomiting in laparoscopic surgery. J Minim Access Surg. 2006; 2:12-5.
• [33]Gupta SD, Pal R, Sarkar A, Mukherjee S, Mitra K, Roy S et al.. Evaluation of Ondansetron-induced QT interval prolongation in the prophylaxis of postoperative emesis. J Nat Sci Biol Med. 2011; 2:119-24.
• [34]Riley RD, Higgins JPT, Deeks JJ. Interpretation of random effects meta-analyses. BMJ. 2011; 342:964-7.
• [35]Higgins JP, Thompson SG, Spiegelhalter DJ. A re-evaluation of random-effects meta-analysis. J R Stat Soc Ser A Stat Soc. 2009; 172:137-59.
• [36]White IR. Multivariate random-effects meta-regression: updates to mvmeta. Stata J. 2011; 11:255-70.
• [37]StataCorp. Stata Statistical Software: Release 13. College Station: StataCorp LP; 2013.
• [38]Choi YS, Shim JK, Ahn SH, Kwak YL. Efficacy comparison of ramosetron with ondansetron on preventing nausea and vomiting in high-risk patients following spine surgery with a single bolus of dexamethasone as an adjunct. Korean J Anesthesiol. 2012; 62:543-7.
• [39]Wang PK, Tsay PJ, Huang CC, Lai HY, Lin PC, Huang SJ et al.. Comparison of dexamethasone with ondansetron or haloperidol for prevention of patient-controlled analgesia-related postoperative nausea and vomiting: a randomized clinical trial. World J Surg. 2012; 36:775-81.
• [40]Ekinci O, Malat I, Isitmangil G, Aydin N. A randomized comparison of droperidol, metoclopramide, tropisetron, and ondansetron for the prevention of postoperative nausea and vomiting. Gynecol Obstet Invest. 2011; 71:59-65.
• [41]Park SK, Cho EJ. A randomized, double-blind trial of palonosetron compared with ondansetron in preventing postoperative nausea and vomiting after gynaecological laparoscopic surgery. J Int Med Res. 2011; 39:399-407.
• [42]Ryu JH, Jeon YT, Hwang JW, Oh AY, Moon JY, Ro YJ et al.. Intravenous, oral, and the combination of intravenous and oral ramosetron for the prevention of nausea and vomiting after laparoscopic cholecystectomy: a randomized, double-blind, controlled trial. Clin Ther. 2011; 33:1162-72.
• [43]Sahoo T, SenDasgupta C, Goswami A, Hazra A. Reduction in spinal-induced hypotension with ondansetron in parturients undergoing caesarean section: a double-blind randomised, placebo-controlled study. Int J Obstet Anesth. 2012; 21:24-8.
• [44]Bilgin TE, Birbicer H, Ozer Z, Doruk N, Tok E, Oral U. A comparative study of the antiemetic efficacy of dexamethasone, ondansetron, and metoclopramide in patients undergoing gynecological surgery. Med Sci Monit. 2010; 16:CR336-341.
• [45]Choi DK, Chin JH, Lee EH, Lim OB, Chung CH, Ro YJ et al.. Prophylactic control of post-operative nausea and vomiting using ondansetron and ramosetron after cardiac surgery. Acta Anaesthesiol Scand. 2010; 54:962-9.
• [46]Jee YS, Yoon HJ, Jang CH. Prophylactic antiemetic effects in gynecologic patients receiving fentanyl IV-patient controlled analgesia: comparison of combined treatment with ondansetron and dexamethasone with metoclopramide and dexamethasone. Korean J Anesthesiol. 2010; 59:335-9.
• [47]Jokela R, Ahonen J, Seitsonen E, Marjakangas P, Korttila K. The influence of ondansetron on the analgesic effect of acetaminophen after laparoscopic hysterectomy. Clin Pharmacol Ther. 2010; 87:672-8.
• [48]Mehta D, Sanatani S, Whyte SD. The effects of droperidol and ondansetron on dispersion of myocardial repolarization in children. Paediatr Anaesth. 2010; 20:905-12.
• [49]Shakya S, Chaturvedi A, Sah BP. Prophylactic low dose ketamine and ondansetron for prevention of shivering during spinal anaesthesia. J Anaesthesiol Clin Pharmacol. 2010; 26:465-9.
• [50]Singla NK, Singla SK, Chung F, Kutsogiannis DJ, Blackburn L, Lane SR et al.. Phase II study to evaluate the safety and efficacy of the oral neurokinin-1 receptor antagonist casopitant (GW679769) administered with ondansetron for the prevention of postoperative and postdischarge nausea and vomiting in high-risk patients. Anesthesiology. 2010; 113:74-82.
• [51]Feng PH, Chu KS, Lu IC, Shieh JP, Tzeng JI, Ho ST et al.. Haloperidol plus ondansetron prevents postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Acta Anaesthesiol Taiwan. 2009; 47:3-9.
• [52]Jain V, Mitra JK, Rath GP, Prabhakar H, Bithal PK, Dash HH. A randomized, double-blinded comparison of ondansetron, granisetron, and placebo for prevention of postoperative nausea and vomiting after supratentorial craniotomy. J Neurosurg Anesthesiol. 2009; 21:226-30.
• [53]Riad W, Marouf H. Combination therapy in the prevention of PONV after strabismus surgery in children: granisetron, ondansetron, midazolam with dexamethasone. Middle East J Anesthesiol. 2009; 20:431-6.
• [54]Rosow CE, Haspel KL, Smith SE, Grecu L, Bittner EA. Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting. Anesth Analg. 2008; 106:1407-9.
• [55]Candiotti KA, Kovac AL, Melson TI, Clerici G, Joo Gan T. Palonosetron 04–06 Study G. A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo for preventing postoperative nausea and vomiting. Anesth Analg. 2008; 107:445-51.
• [56]Choi YS, Shim JK, Yoon do H, Jeon DH, Lee JY, Kwak YL. Effect of ramosetron on patient-controlled analgesia related nausea and vomiting after spine surgery in highly susceptible patients: comparison with ondansetron. Spine (Phila Pa 1976). 2008; 33:E602-6.
• [57]Contreras-Dominguez V, Carbonell-Bellolio P. Prophylactic antiemetic therapy for acute abdominal surgery. A comparative study of droperidol, metoclopramide, tropisetron, granisetron and dexamethasone. Rev Bras Anestesiol. 2008; 58:35-44.
• [58]Kovac AL, Eberhart L, Kotarski J, Clerici G, Apfel C. Palonosetron 04–07 Study G. A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo in preventing postoperative nausea and vomiting over a 72-hour period. Anesth Analg. 2008; 107:439-44.
• [59]Owczuk R, Wenski W, Polak-Krzeminska A, Twardowski P, Arszulowicz R, Dylczyk-Sommer A et al.. Ondansetron given intravenously attenuates arterial blood pressure drop due to spinal anesthesia: a double-blind, placebo-controlled study. Reg Anesth Pain Med. 2008; 33:332-9.
• [60]Piper SN, Rohm K, Boldt J, Kranke P, Maleck W, Seifert R et al.. Postoperative nausea and vomiting after surgery for prognathism: not only a question of patients’ comfort. A placebo-controlled comparison of dolasetron and droperidol. J Craniomaxillofac Surg. 2008; 36:173-9.
• [61]Said-Ahmed HAF. Does granisetron affect the analgesic efficacy of tramadol in patients undergoing abdominal hysterectomy? Acta Anaesthesiologica Italica. 2008; 59:256-66.
• [62]Bestas A, Önal SA, Bayar MK, Yildirim A, Aygen E. Effects of ondansetron and granisetron on postoperative nausea and vomiting in adult patients undergoing laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled clinical trial. Curr Ther Res Clin Exp. 2007; 68:303-12.
• [63]Diemunsch P, Gan TJ, Philip BK, Girao MJ, Eberhart L, Irwin MG et al.. Single-dose aprepitant vs ondansetron for the prevention of postoperative nausea and vomiting: a randomized, double-blind phase III trial in patients undergoing open abdominal surgery. Br J Anaesth. 2007; 99:202-11.
• [64]Gan TJ, Apfel CC, Kovac A, Philip BK, Singla N, Minkowitz H et al.. A randomized, double-blind comparison of the NK1 antagonist, aprepitant, versus ondansetron for the prevention of postoperative nausea and vomiting. Anesth Analg. 2007; 104:1082-9.
• [65]Han DW, Hong SW, Kwon JY, Lee JW, Kim KJ. Epidural ondansetron is more effective to prevent postoperative pruritus and nausea than intravenous ondansetron in elective cesarean delivery. Acta Obstet Gynecol Scand. 2007; 86:683-7.
• [66]Lee Y, Wang PK, Lai HY, Yang YL, Chu CC, Wang JJ. Haloperidol is as effective as ondansetron for preventing postoperative nausea and vomiting. Can J Anaesth. 2007; 54:349-54.
• [67]Oksuz H, Zencirci B, Ezberci M. Comparison of the effectiveness of metoclopramide, ondansetron, and granisetron on the prevention of nausea and vomiting after laparoscopic cholecystectomy. J Laparoendosc Adv Surg Tech A. 2007; 17:803-8.
• [68]Rusch D, Arndt C, Martin H, Kranke P. The addition of dexamethasone to dolasetron or haloperidol for treatment of established postoperative nausea and vomiting. Anaesthesia. 2007; 62:810-7.
• [69]Sagir O, Gulhas N, Toprak H, Yucel A, Begec Z, Ersoy O. Control of shivering during regional anaesthesia: prophylactic ketamine and granisetron. Acta Anaesthesiol Scand. 2007; 51:44-9.
• [70]Sandhu T, Tanvatcharaphan P, Cheunjongkolkul V. Ondansetron versus metoclopramide in prophylaxis of nausea and vomiting for laparoscopic cholecystectomy: a prospective double-blind randomized study. Asian J Surg. 2008; 31:50-4.
• [71]Siddik-Sayyid SM, Aouad MT, Taha SK, Azar MS, Hakki MA, Kaddoum RN et al.. Does ondansetron or granisetron prevent subarachnoid morphine-induced pruritus after cesarean delivery? Anesth Analg. 2007; 104:421-4.
• [72]Bridges JD, Nettle CB, Dugirrala VJ, Suda KJ, Garey KW. Low-dose granisetron for the prevention of postoperative nausea and vomiting. J Appl Res. 2006; 6:223-9.
• [73]Chan MT, Choi KC, Gin T, Chui PT, Short TG, Yuen PM et al.. The additive interactions between ondansetron and droperidol for preventing postoperative nausea and vomiting. Anesth Analg. 2006; 103:1155-62.
• [74]Kelsaka E, Baris S, Karakaya D, Sarihasan B. Comparison of ondansetron and meperidine for prevention of shivering in patients undergoing spinal anesthesia. Reg Anesth Pain Med. 2006; 31:40-5.
• [75]Sarvela PJ, Halonen PM, Soikkeli AI, Kainu JP, Korttila KT. Ondansetron and tropisetron do not prevent intraspinal morphine- and fentanyl-induced pruritus in elective cesarean delivery. Acta Anaesthesiol Scand. 2006; 50:239-44.
• [76]Tosun Z, Akin A, Dogan H, Boyaci A. A randomized, placebo-controlled trial of a single dose of tropisetron for the prevention of vomiting after strabismus surgery in children. Mt Sinai J Med. 2006; 73:1106-11.
• [77]D’Angelo R, Philip B, Gan TJ, Kovac A, Hantler C, Doblar D et al.. A randomized, double-blind, close-ranging, pilot study of intravenous granisetron in the prevention of postoperative nausea and vomiting in patients abdominal hysterectomy. Eur J Anaesthesiol. 2005; 22:774-9.
• [78]Gan TJ, Coop A, Philip BK. A randomized, double-blind study of granisetron plus dexamethasone versus ondansetron plus dexamethasone to prevent postoperative nausea and vomiting in patients undergoing abdominal hysterectomy. Anesth Analg. 2005; 101:1323-9.
• [79]Khalil SN, Roth AG, Cohen IT, Simhi E, Ansermino JM, Bolos ME et al.. A double-blind comparison of intravenous ondansetron and placebo for preventing postoperative emesis in 1- to 24-month-old pediatric patients after surgery under general anesthesia. Anesth Analg. 2005; 101:356-61.
• [80]Kocamanoglu IS, Baris S, Karakaya D, Sener B, Tur A, Cetinkaya M. Effects of granisetron with droperidol or dexamethasone on prevention of postoperative nausea and vomiting after general anesthesia for cesarean section. Methods Find Exp Clin Pharmacol. 2005; 27:489-93.
• [81]Kontrimaviciute E, Baublys A, Ivaskevicius J. Postoperative nausea and vomiting in patients undergoing total abdominal hysterectomy under spinal anaesthesia: a randomized study of ondansetron prophylaxis. Eur J Anaesthesiol. 2005; 22:504-9.
• [82]Pirat A, Tuncay SF, Torgay A, Candan S, Arslan G. Ondansetron, orally disintegrating tablets versus intravenous injection for prevention of intrathecal morphine-induced nausea, vomiting, and pruritus in young males. Anesth Analg. 2005; 101:1330-6.
• [83]Treschan TA, Zimmer C, Nass C, Stegen B, Esser J, Peters J. Inspired oxygen fraction of 0.8 does not attenuate postoperative nausea and vomiting after strabismus surgery. Anesthesiology. 2005; 103:6-10.
• [84]White PF, Scuderi PE. Prevention of postoperative nausea and vomiting (PONV): A dose-ranging study involving palonosetron, a potent 5-HT3 receptor antagonist. Anesthesiology. 2005; 103:A703.
• [85]Apfel CC, Korttila K, Abdalla M, Kerger H, Turan A, Vedder I et al.. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med. 2004; 350:2441-51.
• [86]Binstock W, Rubin R, Bachman C, Kahana M, McDade W, Lynch JP. The effect of premedication with OTFC, with or without ondansetron, on postoperative agitation, and nausea and vomiting in pediatric ambulatory patients. Paediatr Anaesth. 2004; 14:759-67.
• [87]Eberhart LH, Morin AM, Hoerle S, Wulf H, Geldner G. Droperidol and dolasetron alone or in combination for prevention of postoperative nausea and vomiting after vitrectomy. Ophthalmology. 2004; 111:1569-75.
• [88]Hanaoka K, Toyooka H, Kugimiya T, Ohashi Y. Granisetron Study Group of Japan. Efficacy of prophylactic intravenous granisetron in postoperative emesis in adults. J Anesth. 2004; 18:158-65.
• [89]Samarkandi AH, Riad W, Altaf R, Fatani R. Dexamethasone-ondansetron combination in prevention of nausea and vomiting after strabismus surgery in children. Egypt J Anaesth. 2004; 20:399-403.
• [90]Charuluxananan S, Kyokong O, Somboonviboon W, Narasethakamol A, Promlok P. Nalbuphine versus ondansetron for prevention of intrathecal morphine-induced pruritus after cesarean delivery. Anesth Analg. 2003; 96:1789-93.
• [91]Loewen P, Lamb S, Clugston P. Randomized, double-blind trial of dolasetron versus droperidol for prophylaxis of postoperative nausea and vomiting in patients undergoing TRAM flap breast reconstruction surgery. Ann Plast Surg. 2003; 51:472-7.
• [92]O’Brien CM, Titley G, Whitehurst P. A comparison of cyclizine, ondansetron and placebo as prophylaxis against postoperative nausea and vomiting in children. Anaesthesia. 2003; 58:707-11.
• [93]Argiriadou H, Papaziogas B, Pavlidis T, Parlapani A, Georgiou M, Papagiannopoulou P et al.. Tropisetron vs ondansetron for prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: a randomized double-blind, placebo-controlled study. Surg Endosc. 2002; 16:1087-90.
• [94]Gurkan Y, Toker K. Prophylactic ondansetron reduces the incidence of intrathecal fentanyl-induced pruritus. Anesth Analg. 2002; 95:1763-6.
• [95]Dabbous A, Khoury SJ, Chehab IR, Bartelmaos T, Khoury G. Ondansetron versus dehydrobenzoperidol and metoclopramide for management of postoperative nausea in laparoscopic surgery patients. JSLS. 2001; 5:139-42.
• [96]Kathirvel S, Dash HH, Bhatia A, Subramaniam B, Prakash A, Shenoy S. Effect of prophylactic ondansetron on postoperative nausea and vomiting after elective craniotomy. J Neurosurg Anesthesiol. 2001; 13:207-12.
• [97]Subramaniam B, Madan R, Sadhasivam S, Sennaraj B, Tamilselvan P, Rajeshwari S et al.. Dexamethasone is a cost-effective alternative to ondansetron in preventing PONV after paediatric strabismus repair. Br J Anaesth. 2001; 86:84-9.
• [98]Ahmed AB, Hobbs GJ, Curran JP. Randomized, placebo-controlled trial of combination antiemetic prophylaxis for day-case gynaecological laparoscopic surgery. Br J Anaesth. 2000; 85:678-82.
• [99]Charuluxananan S, Somboonviboon W, Kyokong O, Nimcharoendee K. Ondansetron for treatment of intrathecal morphine-induced pruritus after cesarean delivery. Reg Anesth Pain Med. 2000; 25:535-9.
• [100]Jensen AB, Christiansen DB, Coulthard K, Wilkins A, Roberts G, Walt JH et al.. Tropisetron reduces postoperative vomiting in children undergoing tonsillectomy. Paediatr Anaesth. 2000; 10:69-75.
• [101]Kreisler NS, Spiekermann BF, Ascari CM, Rhyne HA, Kloth RL, Sullivan LM et al.. Small-dose droperidol effectively reduces nausea in a general surgical adult patient population. Anesth Analg. 2000; 91:1256-61.
• [102]Philip BK, Pearman MH, Kovac AL, Chelly JE, Wetchler BV, McKenzie R et al.. Dolasetron for the prevention of postoperative nausea and vomiting following outpatient surgery with general anaesthesia: a randomized, placebo-controlled study. The Dolasetron PONV Prevention Study Group. Eur J Anaesthesiol. 2000; 17:23-32.
• [103]Zarate E, Watcha MF, White PF, Klein KW, Sa Rego M, Stewart DG. A comparison of the costs and efficacy of ondansetron versus dolasetron for antiemetic prophylaxis. Anesth Analg. 2000; 90:1352-8.
• [104]Koivuranta M, Ala-Kokko TI, Jokela R, Ranta P. Comparison of ondansetron and tropisetron combined with droperidol for the prevention of emesis in women with a history of post-operative nausea and vomiting. Eur J Anaesthesiol. 1999; 16:390-5.
• [105]McCall JE, Stubbs K, Saylors S, Pohlman S, Ivers B, Smith S et al.. The search for cost-effective prevention of postoperative nausea and vomiting in the child undergoing reconstructive burn surgery: ondansetron versus dimenhydrinate. J Burn Care Rehabil. 1999; 20:309-15.
• [106]Sinha PK, Tripathi M, Ambesh SP. Efficacy of ondansetron in prophylaxis of postoperative nausea and vomiting in patients following infratentorial surgery: a placebo-controlled prospective double-blind study. J Neurosurg Anesthesiol. 1999; 11:6-10.
• [107]Tsui SL, Ng KF, Wong LC, Tang GW, Pun TC, Yang JC. Prevention of postoperative nausea and vomiting in gynaecological laparotomies: a comparison of tropisetron and ondansetron. Anaesth Intensive Care. 1999; 27:471-6.
• [108]Diemunsch P, Korttila K, Leeser J, Helmers JH, Wilkey B, Nave S et al.. Oral dolasetron mesylate for prevention of postoperative nausea and vomiting: a multicenter, double-blind, placebo-controlled study. The Oral Dolasetron PONV Prevention Study Group. J Clin Anesth. 1998; 10:145-52.
• [109]Goodarzi M. A double blind comparison of droperidol and ondansetron for prevention of emesis in children undergoing orthopaedic surgery. Paediatr Anaesth. 1998; 8:325-9.
• [110]Hamid SK, Selby IR, Sikich N, Lerman J. Vomiting after adenotonsillectomy in children: a comparison of ondansetron, dimenhydrinate, and placebo. Anesth Analg. 1998; 86:496-500.
• [111]Morris RW, Aune H, Feiss P, Hanson A, Hasselstrom L, Maltby JR et al.. International, multicentre, placebo-controlled study to evaluate the effectiveness of ondansetron vs. metoclopramide in the prevention of post-operative nausea and vomiting. Eur J Anaesthesiol. 1998; 15:69-79.
• [112]Scholz J, Hennes HJ, Steinfath M, Farber L, Schweiger C, Dick W et al.. Tropisetron or ondansetron compared with placebo for prevention of postoperative nausea and vomiting. Eur J Anaesthesiol. 1998; 15:676-85.
• [113]Tramer MR, Sansonetti A, Fuchs-Buder T, Rifat K. Oculocardiac reflex and postoperative vomiting in paediatric strabismus surgery. A randomised controlled trial comparing four anaesthetic techniques. Acta Anaesthesiol Scand. 1998; 42:117-23.
• [114]Diemunsch P, D’Hollander A, Paxton L, Schoeffler P, Wessel P, Nave S et al.. Intravenous dolasetron mesilate in the prevention of postoperative nausea and vomiting in females undergoing gynecological surgery. J Clin Anesth. 1997; 9:365-73.
• [115]Diemunsch P, Leeser J, Feiss P, D’Hollander A, Bradburn BG, Paxton D et al.. Intravenous dolasetron mesilate ameliorates postoperative nausea and vomiting. Can J Anaesth. 1997; 44:173-81.
• [116]Graczyk SG, McKenzie R, Kallar S, Hickok CB, Melson T, Morrill B et al.. Intravenous dolasetron for the prevention of postoperative nausea and vomiting after outpatient laparoscopic gynecologic surgery. Anesth Analg. 1997; 84:325-30.
• [117]Klockgether-Radke A, Neumann S, Neumann P, Braun U, Muhlendyck H. Ondansetron, droperidol and their combination for the prevention of post-operative vomiting in children. Eur J Anaesthesiol. 1997; 14:362-7.
• [118]Koivuranta M, Laara E, Ranta P, Ravaska P, Alahuhta S. Comparison of ondansetron and droperidol in the prevention of postoperative nausea and vomiting after laparoscopic surgery in women. A randomised, double-blind, placebo-controlled trial. Acta Anaesthesiol Scand. 1997; 41:1273-9.
• [119]Korttila K, Clergue F, Leeser J, Feiss P, Olthoff D, Payeur-Michel C et al.. Intravenous dolasetron and ondansetron in prevention of postoperative nausea and vomiting: a multicenter, double-blind, placebo-controlled study. Acta Anaesthesiol Scand. 1997; 41:914-22.
• [120]Kovac AL, Scuderi PE, Boerner TF, Chelly JE, Goldberg ME, Hantler CB et al.. Treatment of postoperative nausea and vomiting with single intravenous doses of dolasetron mesylate: a multicenter trial. Dolasetron Mesylate PONV Treatment Study Group. Anesth Analg. 1997; 85:546-52.
• [121]Mikawa K, Takao Y, Nishina K, Shiga M, Maekawa N, Obara H. Optimal dose of granisetron for prophylaxis against postoperative emesis after gynecological surgery. Anesth Analg. 1997; 85:652-6.
• [122]Monagle J, Barnes R, Goodchild C, Hewitt M. Ondansetron is not superior to moderate dose metoclopramide in the prevention of post-operative nausea and vomiting after minor gynaecological surgery. Eur J Anaesthesiol. 1997; 14:604-9.
• [123]Morton NS, Camu F, Dorman T, Knudsen KE, Kvalsvik O, Nellgard P et al.. Ondansetron reduces nausea and vomiting after paediatric adenotonsillectomy. Paediatr Anaesth. 1997; 7:37-45.
• [124]Patel RI, Davis PJ, Orr RJ, Ferrari LR, Rimar S, Hannallah RS et al.. Single-dose ondansetron prevents postoperative vomiting in pediatric outpatients. Anesth Analg. 1997; 85:538-45.
• [125]Purhonen S, Kauko M, Koski EM, Nuutinen L. Comparison of tropisetron, droperidol, and saline in the prevention of postoperative nausea and vomiting after gynecologic surgery. Anesth Analg. 1997; 84:662-7.
• [126]Rung GW, Claybon L, Hord A, Patel C, Kallgren M, Koppel J et al.. Intravenous ondansetron for postsurgical opioid-induced nausea and vomiting. S3A-255 Study Group. Anesth Analg. 1997; 84:832-8.
• [127]Scuderi PE, Weaver RG, James RL, Mims G, Elliott WG, Weeks DB. A randomized, double-blind, placebo controlled comparison of droperidol, ondansetron, and metoclopramide for the prevention of vomiting following outpatient strabismus surgery in children. J Clin Anesth. 1997; 9:551-8.
• [128]Taylor AM, Rosen M, Diemunsch PA, Thorin D, Houweling PL. A double-blind, parallel-group, placebo-controlled, dose-ranging, multicenter study of intravenous granisetron in the treatment of postoperative nausea and vomiting in patients undergoing surgery with general anesthesia. J Clin Anesth. 1997; 9:658-63.
• [129]Ulusoy HO, Akturk G, Luleci N, Kalac N, Albayrak D. Prophylactic administration of ondansetron in emergency intraabdominal operations. Middle East J Anesthesiol. 1997; 14:45-58.
• [130]Warriner CB, Knox D, Belo S, Cole C, Finegan BA, Perreault L. Prophylactic oral dolasetron mesylate reduces nausea and vomiting after abdominal hysterectomy. The Canadian Dolasetron Study Group. Can J Anaesth. 1997; 44:1167-73.
• [131]Ali-Melkkila T, Kanto J, Katevuo R. Tropisetron and metoclopramide in the prevention of postoperative nausea and vomiting. A comparative, placebo controlled study in patients undergoing ophthalmic surgery. Anaesthesia. 1996; 51:232-5.
• [132]Capouet V, De Pauw C, Vernet B, Ivens D, Derijcke V, Versichelen L et al.. Single dose i.v. tropisetron in the prevention of postoperative nausea and vomiting after gynaecological surgery. Br J Anaesth. 1996; 76:54-60.
• [133]Kovac AL, Pearman MH, Khalil SN, Scuderi PE, Joslyn AF, Prillaman BA et al.. Ondansetron prevents postoperative emesis in male outpatients. S3A-379 Study Group. J Clin Anesth. 1996; 8:644-51.
• [134]Naguib M, el Bakry AK, Khoshim MH, Channa AB, el Gammal M, el Gammal K et al.. Prophylactic antiemetic therapy with ondansetron, tropisetron, granisetron and metoclopramide in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind comparison with placebo. Can J Anaesth. 1996; 43:226-31.
• [135]Desilva PH, Darvish AH, McDonald SM, Cronin MK, Clark K. The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery. Anesth Analg. 1995; 81:139-43.
• [136]Litman RS, Wu CL, Lee A, Griswold JD, Voisine R, Marshall C. Prevention of emesis after strabismus repair in children: a prospective, double-blinded, randomized comparison of droperidol versus ondansetron. J Clin Anesth. 1995; 7:58-62.
• [137]Paech MJ, Pavy TJ, Evans SF. Single-dose prophylaxis for postoperative nausea and vomiting after major abdominal surgery: ondansetron versus droperidol. Anaesth Intensive Care. 1995; 23:548-54.
• [138]Paxton D, Taylor RH, Gallagher TM, Crean PM. Postoperative emesis following otoplasty in children. Anaesthesia. 1995; 50:1083-5.
• [139]Kaufmann MA, Rosow C, Schnieper P, Schneider M. Prophylactic antiemetic therapy with patient-controlled analgesia: a double-blind, placebo-controlled comparison of droperidol, metoclopramide, and tropisetron. Anesth Analg. 1994; 78:988-94.
• [140]Ummenhofer W, Frei FJ, Urwyler A, Kern C, Drewe J. Effects of ondansetron in the prevention of postoperative nausea and vomiting in children. Anesthesiology. 1994; 81:804-10.
• [141]Dupeyron JP, Conseiller C, Levarlet M, Hemmingsen C, Schoeffler P, Pedersen FM et al.. The effect of oral ondansetron in the prevention of postoperative nausea and vomiting after major gynaecological surgery performed under general anaesthesia. Anaesthesia. 1993; 48:214-8.
• [142]Helmers JH, Briggs L, Abrahamsson J, Soni J, Moodley J, Forrler M et al.. A single i.v. dose of ondansetron 8 mg prior to induction of anaesthesia reduces postoperative nausea and vomiting in gynaecological patients. Can J Anaesth. 1993; 40:1155-61.
• [143]Raphael JH, Norton AC. Antiemetic efficacy of prophylactic ondansetron in laparoscopic surgery: randomized, double-blind comparison with metoclopramide. Br J Anaesth. 1993; 71:845-8.
• [144]Du Pen S, Scuderi P, Wetchler B, Sung YF, Mingus M, Clayborn L et al.. Ondansetron in the treatment of postoperative nausea and vomiting in ambulatory outpatients: a dose-comparative, stratified, multicentre study. Eur J Anaesthesiol Suppl. 1992; 6:55-62.
• [145]Charbit B, Albaladejo P, Funck-Brentano C, Legrand M, Samain E, Marty J. Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron. Anesthesiology. 2005; 102:1094-100.
• [146]Kovac A, McKenzie R, O’Connor T, Duncalf D, Angel J, Gratz I et al.. Prophylactic intravenous ondansetron in female outpatients undergoing gynaecological surgery: a multicentre dose-comparison study. Eur J Anaesthesiol Suppl. 1992; 6:37-47.
• [147]Lerman J, Sims C, Sikich N, Gow R, Chin C, Dempsey E et al.. Pharmacokinetics of the active metabolite (MDL 74,156) of dolasetron mesylate after oral or intravenous administration to anesthetized children. Clin Pharmacol Ther. 1996; 60:485-92.
• [148]Wagner DS, Gauger V, Chiravuri D, Faust K. Ondansetron oral disintegrating tablets for the prevention of postoperative vomiting in children undergoing strabismus surgery. Ther Clin Risk Manag. 2007; 3:691-4.
• [149]Rose JB, Brenn BR, Corddry DH, Thomas PC. Preoperative oral ondansetron for pediatric tonsillectomy. Anesth Analg. 1996; 82:558-62.
• [150]El-Deeb A, Abd el motlb E. Prophylactic multimodal antiemetic in women undergoing cesarean section under spinal anesthesia. Egypt J Anaesth. 2011; 27:107-11.
• [151]Jokela RM, Cakmakkaya OS, Danzeisen O, Korttila KT, Kranke P, Malhotra A et al.. Ondansetron has similar clinical efficacy against both nausea and vomiting. Anaesthesia. 2009; 64:147-51.
• [152]Pearman MH. Single dose intravenous ondansetron in the prevention of postoperative nausea and vomiting. Anaesthesia. 1994; 49:11-5.
• [153]Scuderi P, Wetchler B, Sung YF, Mingus M, DuPen S, Claybon L et al.. Treatment of postoperative nausea and vomiting after outpatient surgery with the 5-HT3 antagonist ondansetron. Anesthesiology. 1993; 78:15-20.
• [154]McKenzie R, Kovac A, O’Connor T, Duncalf D, Angel J, Gratz I et al.. Comparison of ondansetron versus placebo to prevent postoperative nausea and vomiting in women undergoing ambulatory gynecologic surgery. Anesthesiology. 1993; 78:21-8.
• [155]Bagameri A, Bosze P. Ondansetron (Zofran) treatment of chemotherapy induced nausea and vomiting in patients with gynecological malignancies. Magy Noorv Lapja. 1994; 57:291-3.
• [156]Chen LK, Fan SZ, Huang CH, Chao A, Cherng YG, Chen CL et al.. Effects of ondansetron on postoperative emesis in Chinese children. Acta Anaesthesiol Sin. 1998; 36:87-91.
• [157]Ebrahim Soltani AR, Mohammadinasab H, Goudarzi M, Arbabi S, Mohammadinasab A, Mohammadinasab F et al.. Comparing the efficacy of prophylactic p6 acupressure, ondansetron, metoclopramide and placebo in the prevention of vomiting and nausea after strabismus surgery. Acta Med Iran. 2011; 49:208-12.
• [158]Ng WW, Li AC, Lee DW, Leung TL, Ko CW, Leung KF et al.. Effectiveness of Ondansetron to prevent postoperative nausea and vomiting in ambulatory two port needlescopic cholecystectomy: a randomised controlled trial. Ambul Surg. 2008; 14:1-14.
• [159]Aouad MT, Siddik-Sayyid SM, Taha SK, Azar MS, Nasr VG, Hakki MA et al.. Haloperidol vs. ondansetron for the prevention of postoperative nausea and vomiting following gynaecological surgery. Eur J Anaesthesiol. 2007; 24:171-8.
• [160]Freedman SB, Uleryk E, Rumantir M, Finkelstein Y. Ondansetron and the risk of cardiac arrhythmias: a systematic review and postmarketing analysis. Ann Emerg Med. 2014; 64:19-25.
• [161]Rawlinson A, Kitchingham N, Hart C, McMahon G, Ong SL, Khanna A. Mechanisms of reducing postoperative pain, nausea and vomiting: a systematic review of current techniques. Evid Based Med. 2012; 17:75-80.
• [162]Tricco A, Veroniki A, Blondal E, Hamid J, Straus S. Incorporating dosages increases the relevance of network meta-analysis for decision-makers: A case example using data from a systematic review of serotonin (5-HT3) receptor antagonists in patients undergoing surgery. Canadian Association of Pharmacy Technicians (CAPT) Conference, Toronto; 2014.