Serum 25(OH)D concentrations and atopic diseases at age 10: results from the GINIplus and LISAplus birth cohort studies

BMC Pediatrics

Jakob Linseisen^1,10  Dietrich Berdel⁶  Andrea von Berg⁶  Sibylle Koletzko⁹  Carl-Peter Bauer⁷  Irina Lehmann⁴  Barbara Hoffmann⁵  Beate Schaaf⁸  Jürgen Kratzsch²  Elisabeth Thiering³  Joachim Heinrich¹  Nina Wawro^1,10 

[1] Helmholtz Centre Munich, Institute of Epidemiology 1, Neuherberg, Germany;Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany;Ludwig-Maximilians-University Munich, Dr. von Hauner Children’s Hospital, Munich, Germany;UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany;IUF Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany;Department of Pediatrics, Marien-Hospital, Wesel, Germany;Department of Pediatrics, Technical University of Munich, Munich, Germany;Medical Praxis for Children, Bad Honnef, Germany;Department of Pediatrics, Ludwig-Maximilians-University, Munich, Germany;Helmholtz Centre Munich, Institute of Epidemiology 2, Ingolstaedter Landstr 1, Neuherberg, 85764, Germany

关键词: Vitamin D;    Sensitization;    Hay fever;    Birth cohort;    Allergic rhinitis;    Eczema;    Atopic diseases;    Asthma;   

Others  :  1113337
DOI  :  10.1186/s12887-014-0286-3

 received in 2014-04-24, accepted in 2014-10-27,  发布年份 2014

【 摘 要 】

Background

Vitamin D is well recognized for its role in skeletal health and its involvement in the modulation of the immune system. In the literature, controversial results are reported for atopic diseases. Thus, we investigated the association between vitamin D status and the prevalence of atopic diseases.

Methods

Serum 25-hydroxy-vitamin D (25(OH)D) concentrations were measured in a sample of 2815 10-years old children from two German birth cohort studies. Self-reported physician-diagnosed eczema, hay fever or allergic rhinitis, and asthma were used as outcome variables as well as specific IgE positivity against common allergens. We applied logistic regression models, deriving adjusted odds ratio estimates (aOR) and 95% confidence intervals (CI).

Results

For asthma and hay fever or allergic rhinitis, no associations existed with serum 25(OH)D concentrations. We observed a significant positive relationship between serum 25(OH)D levels and eczema at age 10 (aOR = 1.09, CI = 1.01-1.17, per 10 nmol/l increase in serum 25(OH)D levels) and for the lifetime prevalence of eczema (aOR = 1.05, CI = 1.01-1.09). Specific IgE positivity for food allergens (aOR = 1.07, CI = 1.02-1.11) and aeroallergens (aOR = 1.05, CI = 1.01-1.08) at age 10, as well as lifetime prevalence, was significantly related to the vitamin D status.

Conclusion

In this study we found no indication that higher blood 25(OH)D levels are associated with decreased risk for any of the atopic outcomes in children. However, we observed a positive association of serum 25(OH)D concentrations with eczema and detectable specific IgE. Due to the given limitations of our study, the clinical relevance of these findings needs further clarification.

【 授权许可】

   
2014 Wawro et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]von Mutius E: The environmental predictors of allergic disease. J Allergy Clin Immunol 2000, 105:9-19.
• [2]Muehleisen B, Gallo RL: Vitamin D in allergic disease: shedding light on a complex problem. J Allergy Clin Immunol 2013, 131:324-329.
• [3]Krstic G: Asthma prevalence associated with geographical latitude and regional insolation in the United States of America and Australia. PLoS One 2011, 6:e18492.
• [4]Hollams EM: Vitamin D and atopy and asthma phenotypes in children. Curr Opin Allergy Clin Immunol 2012, 12:228-234.
• [5]Searing DA, Leung DY: Vitamin D in atopic dermatitis, asthma and allergic diseases. Immunol Allergy Clin North Am 2010, 30:397-409.
• [6]Mutgi K, Koo J: Update on the role of systemic vitamin d in atopic dermatitis. Pediatr Dermatol 2013, 30:303-307.
• [7]Jones AP, Tulic MK, Rueter K, Prescott SL: Vitamin d and allergic disease: sunlight at the end of the tunnel? Nutrients 2012, 4:13-28.
• [8]Litonjua AA: Vitamin D deficiency as a risk factor for childhood allergic disease and asthma. Curr Opin Allergy Clin Immunol 2012, 12:179-185.
• [9]Paul G, Brehm JM, Alcorn JF, Holguin F, Aujla SJ, Celedon JC: Vitamin D and asthma. Am J Respir Crit Care Med 2012, 185:124-132.
• [10]Bozzetto S, Carraro S, Giordano G, Boner A, Baraldi E: Asthma, allergy and respiratory infections: the vitamin D hypothesis. Allergy 2012, 67:10-17.
• [11]Zerwekh JE: Blood biomarkers of vitamin D status. Am J Clin Nutr 2008, 87:1087S-1091S.
• [12]Litonjua AA, Weiss ST: Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol 2007, 120:1031-1035.
• [13]Camargo CA Jr, Clark S, Kaplan MS, Lieberman P, Wood RA: Regional differences in EpiPen prescriptions in the United States: the potential role of vitamin D. J Allergy Clin Immunol 2007, 120:131-136.
• [14]Osborne NJ, Ukoumunne OC, Wake M, Allen KJ: Prevalence of eczema and food allergy is associated with latitude in Australia. J Allergy Clin Immunol 2012, 129:865-867.
• [15]Jones AP, Palmer D, Zhang G, Prescott SL: Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy. Pediatrics 2012, 130:e1128-e1135.
• [16]Baiz N, Dargent-Molina P, Wark JD, Souberbielle JC, Annesi-Maesano I: Cord serum 25-hydroxyvitamin D and risk of early childhood transient wheezing and atopic dermatitis. J Allergy Clin Immunol 2014, 133:147-153.
• [17]Wjst M, Hypponen E: Vitamin D serum levels and allergic rhinitis. Allergy 2007, 62:1085-1086.
• [18]Weisse K, Winkler S, Hirche F, Herberth G, Hinz D, Bauer M, Roder S, Rolle-Kampczyk U, von Bergen M, Olek S, Sack U, Richter T, Diez U, Borte M, Stangl GI, Lehmann I: Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study. Allergy 2013, 68:220-228.
• [19]Heimbeck I, Wjst M, Apfelbacher CJ: Low vitamin D serum level is inversely associated with eczema in children and adolescents in Germany. Allergy 2013, 68:906-910.
• [20]von Berg A, Koletzko S, Grubl A, Filipiak-Pittroff B, Wichmann HE, Bauer CP, Reinhardt D, Berdel D: The effect of hydrolyzed cow’s milk formula for allergy prevention in the first year of life: the German infant nutritional intervention study, a randomized double-blind trial. J Allergy Clin Immunol 2003, 111:533-540.
• [21]Zutavern A, Rzehak P, Brockow I, Schaaf B, Bollrath C, von Berg A, Link E, Kraemer U, Borte M, Herbarth O, Wichmann HE, Heinrich J: Day care in relation to respiratory-tract and gastrointestinal infections in a German birth cohort study. Acta Paediatr 2007, 96:1494-1499.
• [22]Back O, Blomquist HK, Hernell O, Stenberg B: Does vitamin D intake during infancy promote the development of atopic allergy? Acta Derm Venereol 2009, 89:28-32.
• [23]Peroni DG, Piacentini GL, Cametti E, Chinellato I, Boner AL: Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children. Br J Dermatol 2011, 164:1078-1082.
• [24]Wang SS, Hon KL, Kong AP, Pong HN, Wong GW, Leung TF: Vitamin D deficiency is associated with diagnosis and severity of childhood atopic dermatitis. Pediatr Allergy Immunol 2014, 25:30-35.
• [25]Benson AA, Toh JA, Vernon N, Jariwala SP: The role of vitamin D in the immunopathogenesis of allergic skin diseases. Allergy 2012, 67:296-301.
• [26]Hollams EM, Hart PH, Holt BJ, Serralha M, Parsons F, de Klerk NH, Zhang G, Sly PD, Holt PG: Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study. Eur Respir J 2011, 38:1320-1327.
• [27]Rothers J, Wright AL, Stern DA, Halonen M, Camargo CA Jr: Cord blood 25-hydroxyvitamin D levels are associated with aeroallergen sensitization in children from Tucson, Arizona. J Allergy Clin Immunol 2011, 128:1093-1099. e1091-1095
• [28]Pike KC, Inskip HM, Robinson S, Lucas JS, Cooper C, Harvey NC, Godfrey KM, Roberts G: Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes. Thorax 2012, 67:950-956.
• [29]Camargo CA Jr, Ingham T, Wickens K, Thadhani R, Silvers KM, Epton MJ, Town GI, Pattemore PK, Espinola JA, Crane J: Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. Pediatrics 2011, 127:e180-e187.
• [30]Gale CR, Robinson SM, Harvey NC, Javaid MK, Jiang B, Martyn CN, Godfrey KM, Cooper C: Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr 2008, 62:68-77.
• [31]van Oeffelen AA, Bekkers MB, Smit HA, Kerkhof M, Koppelman GH, Haveman-Nies A, AD v d, Jansen EH, Wijga AH: Serum micronutrient concentrations and childhood asthma: the PIAMA birth cohort study. Pediatr Allergy Immunol 2011, 22:784-793.
• [32]Bener A, Ehlayel MS, Tulic MK, Hamid Q: Vitamin D deficiency as a strong predictor of asthma in children. Int Arch Allergy Immunol 2012, 157:168-175.
• [33]Alyasin S, Momen T, Kashef S, Alipour A, Amin R: The relationship between serum 25 hydroxy vitamin d levels and asthma in children. Allergy Asthma Immunol Res 2011, 3:251-255.
• [34]Checkley W, Robinson CL, Baumann LM, Hansel NN, Romero K, Pollard SL, Wise RA, Gilman RH, Mougey E, Lima JJ, PURA study investigators: 25-hydroxy vitamin D levels are associated with childhood asthma in a population-based study in Peru.Clin Exp Allergy 2014, doi:10.1111/cea.12311. [Epub ahead of print].
• [35]Hypponen E, Berry DJ, Wjst M, Power C: Serum 25-hydroxyvitamin D and IgE - a significant but nonlinear relationship. Allergy 2009, 64:613-620.
• [36]Allen KJ, Koplin JJ, Ponsonby AL, Gurrin LC, Wake M, Vuillermin P, Martin P, Matheson M, Lowe A, Robinson M, Tey D, Osborne NJ, Dang T, Tina Tan HT, Thiele L, Anderson D, Czech H, Sanjeevan J, Zurzolo G, Dwyer T, Tang ML, Hill D, Dharmage SC: Vitamin D insufficiency is associated with challenge-proven food allergy in infants. J Allergy Clin Immunol 2013, 131:1109-1116. 1116 e1101-1106
• [37]Liu X, Wang G, Hong X, Wang D, Tsai HJ, Zhang S, Arguelles L, Kumar R, Wang H, Liu R, Zhou Y, Pearson C, Ortiz K, Schleimer R, Holt PG, Pongracic J, Price HE, Langman C, Wang X: Gene-vitamin D interactions on food sensitization: a prospective birth cohort study. Allergy 2011, 66:1442-1448.
• [38]Yao TC, Tu YL, Chang SW, Tsai HJ, Gu PW, Ning HC, Hua MC, Liao SL, Tsai MH, Chiu CY, Lai SH, Yeh KW, Huang JL: Suboptimal vitamin D status in a population-based study of Asian children: prevalence and relation to allergic diseases and atopy. PLoS One 2014, 9:e99105.
• [39]Linseisen J, Abbas S: Measurement of Serum 25-Hydroxycholecalciferol as Marker of Vitamin D Status. In Dietary Vitamins, Polyphenols, Selenium And Probiotics: Biomarkers of Exposure and Mechanisms of Anticarcinogenic Action Edited by Akesson B, Lodz MP. 2007, 64-70. WP9 ECNICS report
• [40]Prietl B, Treiber G, Pieber TR, Amrein K: Vitamin D and immune function. Nutrients 2013, 5:2502-2521.