Sexually transmitted infections among patients with herpes simplex virus at King Abdulaziz University Hospital

BMC Research Notes

Wafa M K Fageeh¹ 

[1] Department of Obstetrics and Gynecology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia

关键词: Sexually transmitted infections;    Fetal outcome;    Pregnancy;    HIV;    Herpes simplex virus;   

Others  :  1142010
DOI  :  10.1186/1756-0500-6-301

 received in 2013-05-12, accepted in 2013-07-23,  发布年份 2013

【 摘 要 】

Background

Herpes simplex virus (HSV) infection is one of the commonest viral sexually transmitted infections (STIs). The aim of this study was to evaluate the prevalence of STIs among HSV positive patients at a tertiary hospital in Jeddah. Secondary objective of the study included the description of the demographic and clinical profile of patients with HSV and HIV co-infection.

Methods

A retrospective chart review of the medical records was performed for HSV positive women who presented to the emergency room and outpatient department of King Abdulaziz University Hospital, Jeddah, Saudi Arabia between January 1, 2003 and August 30, 2011. Data were collected from the medical records of all the patients and analyzed using the Statistical Package for the Social Sciences.

Results

Three hundred forty-three HSV positive patients were included in this study. Co-infection with HIV was documented in 45 patients (13.1%). Other STIs included chlamydia (n = 43, 12.5%), gonorrhea (n = 44, 12.8%), hepatitis B infection (n = 8, 2.3%), and cytomegalovirus infection (n = 37, 10.8%). Nineteen patients (5.5%) had a total of 47 term pregnancies and five abortions post HSV diagnosis. Genital ulcer disease was diagnosed in 11 (57.9%) of the cases during labor. One newborn developed neonatal herpes infection and subsequently showed delayed psychomotor development during follow up. Genital herpes was diagnosed in one patient’s partner; however, there was no documentation of screening for STIs in the partners of the other patients.

Conclusions

Sexually transmitted infections are relatively common among HSV positive patients at King Abdulaziz University Hospital. Amongst these, HIV is the most common, with a prevalence of 13.1%. Further studies are warranted to evaluate STIs in Saudi Arabia. Health policy makers should adopt a protocol to screen for STIs in the partners of persons who are positive for any STI as early detection and appropriate treatment can improve the outcome.

【 授权许可】

   
2013 Fageeh; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Satterwhite CL, Torrone E, Meites E, Dunne EF, Mahajan R, Ocfemia MC, Su J, Xu F, Weinstock H: Sexually transmitted infections among US women and men: prevalence and incidence estimates, 2008. Sex Transm Dis 2013, 40(3):187-193.
• [2]Centers for Disease Control and Prevention: STD Trends in the United States: 2010 national data for Gonorrhea, chlamydia, and syphilis CDC2010. 2010. http://www.cdc.gov/std/stats10/trends.htm webcite
• [3]World Health Organization: An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection. http://www.who.int/bulletin/volumes/86/10/07-046128-table-T2.html webcite
• [4]Madani TA, Al-Mazrou YY, Al-Jeffri MH, Al-Huzaim NS: Epidemiology of the human immunodeficiency virus in Saudi Arabia; 18-year surveillance results and prevention from an Islamic perspective. BMC Infect Dis 2004, 4:25. BioMed Central Full Text
• [5]Kabbash IA, Al-Mazroa MA, Memish ZA: Evaluation of syndromic management of sexually transmitted infections in Saudi Arabia. J Infect Public Health 2011, 4(2):73-79.
• [6]Madani TA: Sexually transmitted infections in Saudi Arabia. BMC Infect Dis 2006, 10(6):3.
• [7]Xu F, Sternberg MR, Kottiri BJ, McQuillan GM, Lee FK, Nahmias AJ, Berman SM, Markowitz LE: Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States. JAMA 2006, 296:964-973.
• [8]Wald A, Link K: Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis. J Infect Dis 2002, 185(1):45-52.
• [9]Freeman EE, Orroth KK, White RG, Glynn JR, Bakker R, Boily MC, Habbema D, Buvé A, Hayes R: Proportion of new HIV infections attributable to herpes simplex 2 increases over time: simulations of the changing role of sexually transmitted infections in sub-Saharan African HIV epidemics. Sex Transm Infect 2007, 83(Suppl 1):i17-i24.
• [10]Patel P, Bush T, Mayer KH, Desai S, Henry K, Overton ET, Conley L, Hammer J, Brooks JT, SUN Study Investigators: Prevalence and risk factors associated with herpes simplex virus-2 infection in a contemporary cohort of HIV-infected persons in the United States. Sex Transm Dis 2012, 39(2):154-160.
• [11]Sartori E, Calistri A, Salata C, Del Vecchio C, Palù G, Parolin C: Herpes simplex virus type 2 infection increases human immunodeficiency virus type 1 entry into human primary macrophages. Virol J 2011, 8:166. BioMed Central Full Text
• [12]Mayaud P, Nagot N, Konaté I, Ouedraogo A, Weiss HA, Foulongne V, Defer MC, Sawadogo A, Segondy M, Van de Perre P, ANRS 1285 Study Group: Effect of HIV-1 and antiretroviral therapy on herpes simplex virus type 2: a prospective study in African women. Sex Transm Infect 2008, 84:332.
• [13]Forhan S, Dunne E, Sternberg M, Whitehead S, Leelawiwat W, Thepamnuay S, Chen C, Evans-Strickfaden T, McNicholl JM, Markowitz LE: HIV-1 and herpes simplex virus type-2 genital shedding among co-infected women using self-collected swabs in Chiang Rai, Thailand. Int J STD AIDS 2012, 23(8):560-564.
• [14]Posavad CM, Wald A, Kuntz S, Huang ML, Selke S, Krantz E, Corey L: Frequent reactivation of herpes simplex virus among HIV-1-infected patients treated with highly active antiretroviral therapy. J Infect Dis 2004, 190:693.
• [15]Fageeh W: Awareness of sexually transmitted diseases among adolescents in Saudi Arabia. JKAU - Medical Sciences 2009, 15(1):77-90.
• [16]Pinninti SG, Kimberlin DW: Maternal and neonatal herpes simplex virus infections. Am J Perinatol 2013, 30(2):113-119.
• [17]Corey L, Wald A: Maternal and neonatal herpes simplex virus infections. N Engl J Med 2009, 361(14):1376-1385.
• [18]Kimberlin DW, Lin CY, Jacobs RF, Powell DA, Frenkel LM, Gruber WC, Rathore M, Bradley JS, Diaz PS, Kumar M, Arvin AM, Gutierrez K, Shelton M, Weiner LB, Sleasman JW, de Sierra TM, Soong SJ, Kiell J, Lakeman FD, Whitley RJ, National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group: Natural history of neonatal herpes simplex virus infections in the acyclovir era. Pediatrics 2001, 108(2):223-229.
• [19]Mårdh PA: Influence of infection with Chlamydia trachomatis on pregnancy outcome, infant health and life-long sequelae in infected offspring. Best Pract Res Clin Obstet Gynaecol 2002, 16(6):847-864.
• [20]Gomez GB, Kamb ML, Newman LM, Mark J, Broutet N, Hawkes SJ: Untreated maternal syphilis and adverse outcomes of pregnancy: a systematic review and meta-analysis. Bull World Health Organ 2013, 91(3):217-226.
• [21]Ornoy A, Tenenbaum A: Pregnancy outcome following infections by coxsackie, echo, measles, mumps, hepatitis, polio and encephalitis viruses. Reprod Toxicol 2006, 21(4):446-457.
• [22]Kylat RI, Kelly EN, Ford-Jones EL: Clinical findings and adverse outcome in neonates with symptomatic congenital cytomegalovirus (SCCMV) infection. Eur J Pediatr 2006, 165(11):773-778.
• [23]American College of Obstetricians and Gynecologists (ACOG): Management of herpes in pregnancy. Washington (DC): American College of Obstetricians and Gynecologists (ACOG); 2007. p. (ACOG practice bulletin; no. 82)
• [24]Al-Faris EA: The pattern of alternative medicine use among patients attending health centres in a military community in Riyadh. J Family Community Med 2000, 7(2):17-25.
• [25]Al-Jaroudi DH: Beliefs of sub fertile Saudi women. Saudi Med J 2010, 31(4):425-427.
• [26]Mazroa MA, Kabbash IA, Felemban SM, Stephens GM, Al-Hakeem RF, Zumla AI, Memish ZA: HIV case notification rates in the Kingdom of Saudi Arabia over the past decade (2000–2009). PLoS One 2012, 7(9):e45919.
• [27]El-Hazmi MM: Prevalence of HBV, HCV, HIV-1, 2 and HTLV-I/II infections among blood donors in a teaching hospital in the Central region of Saudi Arabia. Saudi Med J 2004, 25(1):26-33.
• [28]Alamawi S, Abutaleb A, Qasem L, Masoud S, Memish Z, Al Khairy K, Kheir O, Bernvil S, Hajeer AH: HIV-1 p24 antigen testing in blood banks: results from Saudi Arabia. Br J Biomed Sci 2003, 60(2):102-104.
• [29]Suligoi B, Cusan M, Santopadre P, Palù G, Catania S, Girelli G, Pala S, Vullo V: HSV-2 specific seroprevalence among various populations in Rome, Italy. The Italian herpes management Forum. Sex Transm Infect 2000, 76(3):213-214.
• [30]Mayor MT, Roett MA, Uduhiri KA: Diagnosis and management of gonococcal infections. Am Fam Physician 2012, 86(10):931-938.
• [31]Krivochenitser R, Jones JS, Whalen D, Gardiner C: Under recognition of cervical Neisseria gonorrhoeae and Chlamydia trachomatis infections in pregnant patients in the ED. Am J Emerg Med 2013, 31(4):661-663.