Self-reported exercise and longitudinal outcomes in cystic fibrosis: a retrospective cohort study

BMC Pulmonary Medicine

Shruti M Paranjape¹  Garry R Cutting¹  Christopher B Morrow¹  Karen S Raraigh¹  Scott M Blackman¹  Joseph M Collaco¹ 

[1] Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins Medical Institutions, David M. Rubenstein Building, 200 North Wolfe Street, 21287 Baltimore, MD, USA

关键词: Exercise;    Body mass index;    FEV₁;    Lung function;    Cystic fibrosis;   

Others  :  1091895
DOI  :  10.1186/1471-2466-14-159

 received in 2014-06-07, accepted in 2014-09-29,  发布年份 2014

【 摘 要 】

Background

Cystic fibrosis (CF) is characterized by recurrent respiratory infections and progressive lung disease. Whereas exercise may contribute to preserving lung function, its benefit is difficult to ascertain given the selection bias of healthier patients being more predisposed to exercise. Our objective was to examine the role of self-reported exercise with longitudinal lung function and body mass index (BMI) measures in CF.

Methods

A total of 1038 subjects with CF were recruited through the U.S. CF Twin-Sibling Study. Questionnaires were used to determine exercise habits. Questionnaires, chart review, and U.S. CF Foundation Patient Registry data were used to track outcomes.

Results

Within the study sample 75% of subjects self-reported regular exercise. Exercise was associated with an older age of diagnosis (p = 0.002), older age at the time of ascertainment (p < 0.001), and higher baseline FEV₁ (p = 0.001), but not CFTR genotype (p = 0.64) or exocrine pancreatic function (p = 0.19). In adjusted mixed models, exercise was associated with both a reduced decline in FEV₁ (p < 0.001) and BMI Z-score (p = 0.001) for adults, but not children aged 10–17 years old.

Conclusions

In our retrospective study, self-reported exercise was associated with improved longitudinal nutritional and pulmonary outcomes in cystic fibrosis for adults. Although prospective studies are needed to confirm these associations, programs to promote regular exercise among individuals with cystic fibrosis would be beneficial.

【 授权许可】

   
2014 Collaco et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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