P Selectins and immunological profiles in HCV and Schistosoma mansoni induced chronic liver disease

BMC Gastroenterology

Maha MA Basyoni¹  Shawky A Fouad²  Mahmoud M Kamel³ 

[1] Department of Medical Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt;Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt;Department of Clinical Pathology, National Cancer Institute Cairo University, Cairo, Egypt

关键词: Lymphocyte activation;    CD62;    Activated platelets;    Schistosomiasis mansoni;    HCV;   

Others  :  1121867
DOI  :  10.1186/1471-230X-14-132

 received in 2014-06-05, accepted in 2014-07-17,  发布年份 2014

【 摘 要 】

Background

Hepatitis C virus (HCV) and Schistosoma mansoni are major causes of chronic liver disease (CLD) in which immune alteration is common. Recent studies suggested that certain platelets and lymphocytes activation markers may have an impact on progression of CLD. This study aimed to evaluate the potential of platelets and lymphocytes activation molecules expression on the pathogenesis of CLD in distinct or concomitant chronic HCV and schistosomiasis mansoni infections.

Methods

The study populations were divided into group-I: patients with chronic schistosomiasis mansoni, group-II: HCV patients without cirrhosis, group-III: patients with combined liver diseases without cirrhosis, group-IV: patients with chronic HCV and liver cirrhosis and group-V: Age and sex matched healthy individuals as normal controls. All groups were subjected to full clinical evaluation, ELISA anti-HCV antibodies screening, parasitological examination for diagnosing S. mansoni and flow cytometry for lymphocyte (CD3, CD4, CD8, CD19, CD22, & CD56) and platelets activation (CD41, CD42 & CD62P (P- selectins)) markers.

Results

The platelet count was significantly decreased in HCV and/or S. mansoni patients. The total T-lymphocytes and T-helper cells were significantly reduced, while T-cytotoxics were increased. The patients possessed a significantly higher platelets activation marker; CD62P (P-selectins) and higher mean fluorescent intensity (MFI) positivity. There were considerable correlations between platelets count and both of CD62P and MFI.

Conclusion

Our Findings suggest an increased expression of certain platelets and lymphocytes activation markers in chronic HCV and S. mansoni induced CLD that may have a role in disease progression.

【 授权许可】

   
2014 Kamel et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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