Echium oil is not protective against weight loss in head and neck cancer patients undergoing curative radio(chemo)therapy: a randomised-controlled trial

BMC Complementary and Alternative Medicine

Philip R Debruyne³  Imogen Foubert⁶  Sylvie Rottey²  Stefan Goemaere⁸  Alex Maes⁵  Fréderic Duprez¹  Laurence Goethals⁷  Hans Pottel⁴  Tom Boterberg³  Michelle Lycke³  Lies Pottel³ 

[1] Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium;Department of Medical Oncology, Ghent University Hospital, Ghent, Belgium;Ageing and Cancer Research Cluster, Centre for Positive Ageing, University of Greenwich, London, UK;Department of Public Health and Primary Care, Catholic University Leuven Kulak, Kortrijk, Belgium;Department of Nuclear Medicine, General Hospital Groeninge, Kortrijk, Belgium;Department of Microbial and Molecular Systems, Food Science and Nutrition Research Centre (LForCe), Catholic University Leuven Kulak, Kortrijk, Belgium;Cancer Centre, General Hospital Groeninge, Loofstraat 43, B-8500 Kortrijk, Belgium;Department of Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, Ghent, Belgium

关键词: Curative intent;    Radio(chemo)therapy;    Weight loss;    Echium oil;    Cachexia;    Head and neck cancer;   

Others  :  1086307
DOI  :  10.1186/1472-6882-14-382

 received in 2014-09-04, accepted in 2014-09-26,  发布年份 2014

【 摘 要 】

Background

Therapy-induced mucositis and dysphagia puts head and neck (H&N) cancer patients at increased risk for developing cachexia. Omega-3 fatty acids (n-3 FA) have been suggested to protect against cachexia. We aimed to examine if echium oil, a plant source of n-3 FA, could reduce weight loss in H&N cancer patients undergoing radio(chemo)therapy with curative intent.

Methods

In a double-blind trial, patients were randomly assigned to echium oil (intervention (I) group; 7.5 ml bis in die (b.i.d.), 235 mg/ml α-linolenic acid (ALA) + 95 mg/ml stearidonic acid (SDA) + 79 mg/ml γ-linolenic acid (GLA)) or n-3 FA deficient sunflower oil high oleic (control (C) group; 7.5 ml b.i.d.) additional to standard nutritional support during treatment. Differences in percentage weight loss between both groups were analysed according to the intention-to-treat principle. Erythrocyte FA profile, body composition, nutritional status and quality of life were collected.

Results

Ninety-one eligible patients were randomised, of whom 83 were evaluable. Dietary supplement adherence was comparable in both groups (median, I: 87%, C: 81%). At week 4, the I group showed significantly increased values of erythrocyte n-3 eicosapentanoic acid (EPA, 14% vs −5%) and n-6 GLA (42% vs −20%) compared to the C group, without a significant change in n-6 arachidonic acid (AA, 2% vs −1%). Intention-to-treat analysis could not reveal a significant reduction in weight loss related to echium oil consumption (median weight loss, I: 8.9%, C: 7.6%). Also, no significant improvement was observed in the other evaluated anthropometric parameters.

Conclusions

Echium oil effectively increased erythrocyte EPA and GLA FAs in H&N cancer patients. It failed however to protect against weight loss, or improve nutritional parameters.

Trial registration

ClinicalTrials.gov Identifier NCT01596933.

【 授权许可】

   
2014 Pottel et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 2.

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