Inflammatory gene variants and the risk of biliary tract cancers and stones: a population-based study in China

BMC Cancer

Gabriella Andreotti²  Stephen Chanock⁷  Hong Zhang⁸  Kai Yu²  Shelley Niwa⁶  Bai-He Zhang^1,10  Tian-Qua Han⁵  Bing-Shen Wang³  Ming-Chang Shen⁴  Lisa W Chu²  Asif Rashid⁹  Yu-Tang Gao¹  Ann W Hsing²  Jill Koshiol²  Felipe A Castro² 

[1]Shanghai Cancer Institute, Shanghai, China

[2]Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., EPS 7063, Rockville, MD, 20892, USA

[3]Zhongshan Hospital, Fudan University, Shanghai, China

[4]Shanghai Tumor Hospital, Shanghai, China

[5]Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai, China

[6]Westat, Rockville, MD, USA

[7]Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Advanced Technology Center, Bethesda, Maryland, 20892-4605, USA

[8]Institute of Biostatistics, School of Life Science, Fudan University, Shanghai, China

[9]Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA

[10]Institute of Oriental Hepatobiliary Surgery, Second Military Medical University, Shanghai, China

关键词: Genetic susceptibility;    Inflammation;    Biliary stones;    Biliary tract cancer;   

Others  :  1080141
DOI  :  10.1186/1471-2407-12-468

 received in 2012-05-03, accepted in 2012-10-02,  发布年份 2012

【 摘 要 】

Background

Genetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies.

Methods

To follow-up on these findings, we examined 35 single nucleotide polymorphism (SNPs) in 5 genes related to inflammation (IL8, NFKBIL, RNASEL, TNF, and VEGFA) in 456 participants with incident biliary tract cancer cases (262 gallbladder, 141 extrahepatic bile duct, 53 ampulla of Vater), 982 participants with biliary stones, and 860 healthy controls in a population–based case–control study in Shanghai, China.

Results

Suggestive associations were observed for SNPs in VEGFA with biliary stones, IL8 with gallbladder and ampulla of Vater cancers, and RNASEL with ampulla of Vater cancer (false discovery rate≤0.2).

Conclusion

These findings provide additional support for the role of inflammation in biliary stones and biliary tract cancer risk and need further validation.

【 授权许可】

   
2012 Castro et al.; licensee BioMed Central Ltd.

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