Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression

BMC Medicine

Daniel F Hermens²  Elizabeth M Scott¹  Rébecca Robillard²  Sharon L Naismith²  Ian B Hickie² 

[1] School of Medicine, The University of Notre Dame, 160 Oxford St, Darlinghurst, Sydney, NSW, 2010, Australia;Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, 100 Mallett St, Camperdown, NSW, 2050, Australia

关键词: Circadian rhythms;    Sleep-wake cycle;    Major depression;   

Others  :  857131
DOI  :  10.1186/1741-7015-11-79

 received in 2012-07-30, accepted in 2013-03-01,  发布年份 2013

【 摘 要 】

Background

Clinical psychiatry has always been limited by the lack of objective tests to substantiate diagnoses and a lack of specific treatments that target underlying pathophysiology. One area in which these twin failures has been most frustrating is major depression. Due to very considerable progress in the basic and clinical neurosciences of sleep-wake cycles and underlying circadian systems this situation is now rapidly changing.

Discussion

The development of specific behavioral or pharmacological strategies that target these basic regulatory systems is driving renewed clinical interest. Here, we explore the extent to which objective tests of sleep-wake cycles and circadian function - namely, those that measure timing or synchrony of circadian-dependent physiology as well as daytime activity and nighttime sleep patterns - can be used to identify a sub-class of patients with major depression who have disturbed circadian profiles.

Summary

Once this unique pathophysiology is characterized, a highly personalized treatment plan can be proposed and monitored. New treatments will now be designed and old treatments re-evaluated on the basis of their effects on objective measures of sleep-wake cycles, circadian rhythms and related metabolic systems.

【 授权许可】

   
2013 Hickie et al.; licensee BioMed Central Ltd.

【 图 表 】

【 参考文献 】

• [1]Horowitz AV, Wakefield JC: The Loss of Sadness: How Psychiatry Transformed Normal Sorrow into Depressive Disorder. New York: Oxford University Press; 2007.
• [2]Shorter E: Before Prozac: The Troubled History of Mood Disorders in Psychiatry. New York: Oxford University Press; 2009.
• [3]DSM-5: the future of psychiatric diagnosis http://www.dsm5.org/Pages/Default.aspx webcite
• [4]Diagnosing the D.S.M http://www.nytimes.com/2012/05/12/opinion/break-up-the-psychiatric-monopoly.html webcite
• [5]Psychiatry’s bible, the DSM, is doing more harm than good http://articles.washingtonpost.com/2012-04-27/opinions/35450916_1_bipolar-disorder-psychiatric-ward-psychiatric-drugs webcite
• [6]Hyman SE: Can neuroscience be integrated into the DSM-V? Nat Rev Neurosci 2007, 8:725-732.
• [7]Miller G: Is pharma running out of brainy ideas? Science 2010, 329:502-504.
• [8]Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJL: Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 2006, 367:1747-1757.
• [9]Gustavsson A, Svensson M, Jacobi F, Allgulander C, Alonso J, Beghi E, Dodel R, Ekman M, Faravelli C, Fratiglioni L, Gannon B, Jones DH, Jennum P, Jordanova A, Jonsson L, Karampampa K, Knapp M, Kobelt G, Kurth T, Lieb R, Linde M, Ljungcrantz C, Maercker A, Melin B, Moscarelli M, Musayev A, Norwood F, Preisig M, Pugliatti M, Rehm J: Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 2011, 21:718-779.
• [10]Bloom DE, Cafiero ET, Jané-Llopis E, Abrahams-Gessel S, Bloom LR, Fathima S, Feigl AB, Gaziano T, Mowafi M, Pandya A, Prettner K, Rosenberg L, Seligman B, Stein AZ, Weinstein C: The Global Economic Burden of Non-Communicable Diseases. Geneva: World Economic Forum; 2011. Available at: http://www3.weforum.org/docs/WEF_Harvard_HE_GlobalEconomicBurdenNonCommunicableDiseases_2011.pdf webcite
• [11]Insel TR: The arrival of preemptive psychiatry. Early Interv Psychiatry 2007, 1:5-6.
• [12]Insel TR: Translating scientific opportunity into public health impact: a strategic plan for research on mental illness. Arch Gen Psychiatry 2009, 66:128-133.
• [13]Hickie IB, Scott EM, Hermens DF, Naismith SL, Guastella AJ, Kaur M, Sidis A, Whitwell B, Glozier N, Pantelis C, Wood SJ, McGorry PD: Applying a clinical staging framework in young people who present with admixtures of anxious, depressive or psychotic symptoms. Early Interv Psychiatry 2013, 7:31-43.
• [14]Scott EM, Hermens DF, Glozier N, Naismith SL, Guastella AJ, Hickie IB: Targeted primary care-based mental health services for young Australians. Med J Aust 2012, 196:136-140.
• [15]McGorry PD, Yung AR, Pantelis C, Hickie IB: A clinical trials agenda for testing interventions in earlier stages of psychotic disorders. Med J Aust 2009, 190:S33-S36.
• [16]Hickie IB, Naismith SL, Norrie LM, Scott EM: Managing depression across the life cycle: new strategies for clinicians and their patients. Intern Med J 2009, 39:720-727.
• [17]Hickie IB, Naismith SL, Ward PB, Little CL, Pearson M, Scott EM, Mitchell P, Wilhelm K, Parker G: Psychomotor slowing in older patients with major depression: relationships with blood flow in the caudate nucleus and white matter lesions. Psychiatry Res 2007, 155:211-220.
• [18]Hickie I, Naismith S, Ward PB, Turner K, Scott E, Mitchell P, Wilhelm K, Parker G: Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression. Br J Psychiatry 2005, 186:197-202.
• [19]Naismith SL, Norrie LM, Mowszowski L, Hickie IB: The neurobiology of depression in later-life: clinical, neuropsychological, neuroimaging and pathophysiological features. Prog Neurobiol 2012, 98:99-143.
• [20]Carroll BJ: Dexamethasone suppression test: a review of contemporary confusion. J Clin Psychiatry 1985, 46:13-24.
• [21]Carroll BJ: Informed use of the dexamethasone suppression test. J Clin Psychiatry 1986, 47:10-12.
• [22]Wray NR, Pergadia ML, Blackwood DH, Penninx BW, Gordon SD, Nyholt DR, Ripke S, MacIntyre DJ, McGhee KA, Maclean AW, Smit JH, Hottenga JJ, Willemsen G, Middeldorp CM, de Geus EJ, Lewis CM, McGuffin P, Hickie IB, van den Oord EJ, Liu JZ, Macgregor S, McEvoy BP, Byrne EM, Medland SE, Statham DJ, Henders AK, Heath AC, Montgomery GW, Martin NG, Boomsma DI: Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. Mol Psychiatry 2010, 17:36-48.
• [23]Thase ME, Larsen KG, Kennedy SH: Assessing the 'true' effect of active antidepressant therapy v. placebo in major depressive disorder: use of a mixture model. Br J Psychiatry 2011, 199:501-507.
• [24]Turner EH, Matthews AM, Linardatos E, Tell RA, Rosenthal R: Selective publication of antidepressant trials and its influence on apparent efficacy. N Engl J Med 2008, 358:252-260.
• [25]Fournier JC, DeRubeis RJ, Hollon SD, Dimidjian S, Amsterdam JD, Shelton RC, Fawcett J: Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA 2010, 303:47-53.
• [26]Simon GE: How can we know whether antidepressants increase suicide risk? Am J Psychiatry 2006, 163:1861-1863.
• [27]Yung AR, McGorry PD: The initial prodrome in psychosis: descriptive and qualitative aspects. Aust N Z J Psychiatry 1996, 30:587-599.
• [28]Yung AR, Stanford C, Cosgrave E, Killackey E, Phillips L, Nelson B, McGorry PD: Testing the Ultra High Risk (prodromal) criteria for the prediction of psychosis in a clinical sample of young people. Schizophr Res 2006, 84:57-66.
• [29]Amminger GP, Leicester S, Yung AR, Phillips LJ, Berger GE, Francey SM, Yuen HP, McGorry PD: Early-onset of symptoms predicts conversion to non-affective psychosis in ultra-high risk individuals. Schizophr Res 2006, 84:67-76.
• [30]Bromet E, Andrade L, Hwang I, Sampson N, Alonso J, de Girolamo G, de Graaf R, Demyttenaere K, Hu C, Iwata N, Karam A, Kaur J, Kostyuchenko S, Lepine J-P, Levinson D, Matschinger H, Mora M, Browne M, Posada-Villa J, Viana M, Williams D, Kessler R: Cross-national epidemiology of DSM-IV major depressive episode. BMC Med 2011, 9:90.
• [31]Scott EM, Hermens DF, Naismith SL, Guastella AJ, De Regt T, White D, Lagopoulos J, Hickie IB: Distinguishing young people with emerging bipolar disorders from those with unipolar depression. J Affect Disord 2013, 144:208-215.
• [32]Hickie IB, Luscombe GM, Davenport TA, Burns JM, Highet NJ: Perspectives of young people on depression: awareness, experiences, attitudes and treatment preferences. Early Interv Psychiatry 2007, 1:333-339.
• [33]Hamilton BA, Naismith SL, Scott EM, Purcell S, Hickie IB: Disability is already pronounced in young people with early stages of affective disorders: Data from an early intervention service. J Affect Disord 2011, 131:84-91.
• [34]Hickie IB, Rogers NL: Novel melatonin-based therapies: potential advances in the treatment of major depression. Lancet 2011, 378:621-631.
• [35]Germain A, Kupfer DJ: Circadian rhythm disturbances in depression. Hum Psychopharmacol Clin Exp 2008, 23:571-585.
• [36]Pandi-Perumal SR, Moscovitch A, Srinivasan V, Spence DW, Cardinali DP, Brown GM: Bidirectional communication between sleep and circadian rhythms and its implications for depression: lessons from agomelatine. Prog Neurobiol 2009, 88:264-271.
• [37]Boivin DB: Influence of sleep-wake and circadian rhythm disturbances in psychiatric disorders. J Psychiatry Neurosci 2000, 25:446-458.
• [38]Van den Hoofdakker RH: Chronobiological theories of nonseasonal affective disorders and their implications for treatment. J Biol Rhythms 1994, 9:157-183.
• [39]Glozier N, Martiniuk A, Patton G, Ivers R, Li Q, Hickie I, Senserrick T, Woodward M, Norton R, Stevenson M: Short sleep duration in prevalent and persistent psychological distress in young adults: the DRIVE study. Sleep 2010, 33:1139-1145.
• [40]Boivin DB, Czeisler CA, Dijk DJ, Duffy JF, Folkard S, Minors DS, Totterdell P, Waterhouse JM: Complex interaction of the sleep-wake cycle and circadian phase modulates mood in healthy subjects. Arch Gen Psychiatry 1997, 54:145-152.
• [41]Surridge-David M, MacLean A, Coulter ME, Knowles JB: Mood change following an acute delay of sleep. Psychiatry Res 1987, 22:149-158. Erratum: Psychiatry Res 1988, 24:121
• [42]Naismith SL, Hermens DF, Ip TK, Bolitho S, Scott E, Rogers NL, Hickie IB: Circadian profiles in young people during the early stages of affective disorder. Transl Psychiatry 2012, 2:e123.
• [43]Naismith SL, Rogers NL, Lewis SJ, Terpening Z, Ip T, Diamond K, Norrie L, Hickie IB: Sleep disturbance relates to neuropsychological functioning in late-life depression. J Affect Disord 2011, 132:139-145.
• [44]Storch EA, Murphy TK, Lack CW, Geffken GR, Jacob ML, Goodman WK: Sleep-related problems in pediatric obsessive-compulsive disorder. J Anxiety Dis 2008, 22:877-885.
• [45]Robillard R, Lambert T, Whitwell BG, Ip TK, Hickie IB, Rogers NL: Sleep-wake patterns and mood disturbances in patients with psychotic disorders: a controlled study. Proceedings of the 4th International Congress of the Association of Sleep Medicine (WASM) & 5th Conference of the Canadian Sleep Society (CSS) September 2011, 10-14. Quebec City. Sleep Med 2011, 12:S53
• [46]Mohawk JA, Green CB, Takahashi JS: Central and peripheral circadian clocks in mammals. Annu Rev Neurosci 2012, 35:445-462.
• [47]Albrecht U: Timing to perfection: the biology of central and peripheral circadian clocks. Neuron 2012, 74:246-260.
• [48]Welsh DK, Takahashi JS, Kay SA: Suprachiasmatic nucleus: cell autonomy and network properties. Annu Rev Physiol 2010, 72:551-577.
• [49]Lowrey PL, Takahashi JS: Genetics of circadian rhythms in mammalian model organisms. Adv Genet 2011, 74:175-230.
• [50]Koike N, Yoo SH, Huang HC, Kumar V, Lee C, Kim TK, Takahashi JS: Transcriptional architecture and chromatin landscape of the core circadian clock in mammals. Science 2012, 338:349-354.
• [51]Panda S, Hogenesch JB: It's all in the timing: many clocks, many outputs. J Biol Rhythms 2004, 19:374-387.
• [52]Takahashi JS, Shimomura K, Kumar V: Searching for genes underlying behavior: lessons from circadian rhythms. Science 2008, 322:909-912.
• [53]Chen Z, Yoo SH, Takahashi JS: Small molecule modifiers of circadian clocks. Cell Mol Life Sci 2012. Epub ahead of print
• [54]Etchegaray JP, Yu EA, Indic P, Dallmann R, Weaver DR: Casein kinase 1 delta (CK1delta) regulates period length of the mouse suprachiasmatic circadian clock in vitro. PLoS One 2010, 5:e10303.
• [55]Etchegaray JP, Machida KK, Noton E, Constance CM, Dallmann R, Di Napoli MN, DeBruyne JP, Lambert CM, Yu EA, Reppert SM, Weaver DR: Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol 2009, 29:3853-3866.
• [56]Xu Y, Padiath QS, Shapiro RE, Jones CR, Wu SC, Saigoh N, Saigoh K, Ptácek LJ, Fu YH: Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature 2005, 434:640-644.
• [57]Vatine G, Vallone D, Gothilf Y, Foulkes NS: It’s time to swim! Zebrafish and the circadian clock. FEBS Lett 2011, 585:1485-1494.
• [58]McClung CA: Circadian rhythms and mood regulation: insights from pre-clinical models. Eur Neuropsychopharmacol 2011, 21(Supplement 4):S683-S693.
• [59]Cade JF: Lithium salts in the treatment of psychotic excitement. Med J Aust 1949, 2:349-352.
• [60]Hirota T, Lewis WG, Liu AC, Lee JW, Schultz PG, Kay SA: A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3 beta. Proc Natl Acad Sci U S A 2008, 105:20746-20751.
• [61]Lachman HM, Pedrosa E, Petruolo OA, Cockerham M, Papolos A, Novak T, Papolos DF, Stopkova P: Increase in GSK3β gene copy number variation in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 2007, 144B:259-265.
• [62]Kozikowski AP, Gunosewoyo H, Guo S, Gaisina IN, Walter RL, Ketcherside A, McClung CA, Mesecar AD, Caldarone B: Identification of a glycogen synthase kinase-3beta inhibitor that attenuates hyperactivity in CLOCK mutant mice. Chem Med Chem 2011, 6:1593-1602.
• [63]Arey R, McClung CA: An inhibitor of casein kinase 1 epsilon/delta partially normalizes the manic-like behaviors of the ClockDelta19 mouse. Behav Pharmacol 2012, 23:392-396.
• [64]Isojima Y, Nakajima M, Ukai H, Fujishima H, Yamada RG, Masumoto KH, Kiuchi R, Ishida M, Ukai-Tadenuma M, Minami Y, Kito R, Nakao K, Kishimoto W, Yoo SH, Shimomura K, Takao T, Takano A, Kojima T, Nagai K, Sakaki Y, Takahashi JS, Ueda HR: CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock. Proc Natl Acad Sci U S A 2009, 106:15744-15749.
• [65]Mendoza J, Clesse D, Pévet P, Challet E: Food-reward signalling in the suprachiasmatic clock. J Neurochem 2010, 112:1489-1499.
• [66]Mendoza J: Circadian clocks: setting time by food. J Neuroendocrinol 2007, 19:127-137.
• [67]Van Gelder RN: How the clock sees the light. Nat Neurosci 2008, 11:628-630.
• [68]Guido ME, Garbarino-Pico E, Contin MA, Valdez DJ, Nieto PS, Verra DM, Acosta-Rodriguez VA, de Zavalía N, Rosenstein RE: Inner retinal circadian clocks and non-visual photoreceptors: novel players in the circadian system. Prog Neurobiol 2010, 92:484-504.
• [69]Cermakian N, Sassone-Corsi P: Environmental stimulus perception and control of circadian clocks. Curr Opin Neurobiol 2002, 12:359-365.
• [70]Hidalgo MP, Caumo W, Posser M, Coccaro SB, Camozzato AL, Chaves ML: Relationship between depressive mood and chronotype in healthy subjects. Psychiatry Clin Neurosci 2009, 63:283-290.
• [71]Drennan MD, Klauber MR, Kripke DF, Goyette LM: The effects of depression and age on the Horne-Ostberg morningness-eveningness score. J Affect Disord 1991, 23:93-98.
• [72]Hakkarainen R, Johansson C, Kieseppa T, Partonen T, Koskenvuo M, Kaprio J, Lonnqvist J: Seasonal changes, sleep length and circadian preference among twins with bipolar disorder. BMC Psychiatry 2003, 3:6.
• [73]Dzirasa K, Coque L, Sidor MM, Kumar S, Dancy EA, Takahashi JS, McClung CA, Nicolelis MA: Lithium ameliorates nucleus accumbens phase-signaling dysfunction in a genetic mouse model of mania. J Neurosci 2010, 30:16314-16323.
• [74]Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA Jr, McClung CA: Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A 2007, 104:6406-6411.
• [75]McClung CA, Sidiropoulou K, Vitaterna M, Takahashi JS, White FJ, Cooper DC, Nestler EJ: Regulation of dopaminergic transmission and cocaine reward by the clock gene. Proc Natl Acad Sci U S A 2005, 102:9377-9381.
• [76]Spencer S, Torres-Altoro MI, Falcon E, Arey R, Marvin M, Goldberg M, Bibb JA, McClung CA: A mutation in CLOCK leads to altered dopamine receptor function. J Neurochem 2012, 123:124-134.
• [77]Spencer S, Falcon E, Kumar J, Krishnan V, Mukherjee S, Birnbaum SG, McClung CA: Circadian genes period 1 and period 2 in the nucleus accumbens regulate anxiety-related behavior. Eur J Neurosci 2013, 37:242-250.
• [78]Mongrain V, Cermakian N: Clock genes in health and disease. J Appl Biomed 2009, 7:15-33.
• [79]Takahashi JS, Hong HK, Ko CH, McDearmon EL: The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet 2008, 9:764-775.
• [80]Hardeland R, Cardinali DP, Srinivasan V, Spence DW, Brown GM, Pandi-Perumal SR: Melatonin - a pleiotropic, orchestrating regulator molecule. Prog Neurobiol 2011, 93:350-384.
• [81]Shimomura K, Lowrey PL, Vitaterna MH, Buhr ED, Kumar V, Hanna P, Omura C, Izumo M, Low SS, Barrett RK, LaRue SI, Green CB, Takahashi JS: Genetic suppression of the circadian clock mutation by the melatonin biosynthesis pathway. Proc Natl Acad Sci U S A 2010, 107:8399-8403.
• [82]Bertolucci C, Cavallari N, Colognesi I, Aguzzi J, Chen Z, Caruso P, Foa A, Tosini G, Bernardi F, Pinotti M: Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators. Mol Cell Biol 2008, 28:3070-3075.
• [83]Stokkan KA, Yamazaki S, Tei H, Sakaki Y, Menaker M: Entrainment of the circadian clock in the liver by feeding. Science 2001, 291:490-493.
• [84]Storch KF, Lipan O, Leykin I, Viswanathan N, Davis FC, Wong WH, Weitz CJ: Extensive and divergent circadian gene expression in liver and heart. Nature 2002, 417:78-83.
• [85]Muhlbauer E, Wolgast S, Finckh U, Peschke D, Peschke E: Indication of circadian oscillations in the rat pancreas. FEBS Lett 2004, 564:91-96.
• [86]Sadacca LA, Lamia KA, DeLemos AS, Blum B, Weitz CJ: An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice. Diabetologia 2011, 54:120-124.
• [87]Bass J, Takahashi JS: Circadian integration of metabolism and energetics. Science 2010, 330:1349-1354.
• [88]Solt LA, Wang Y, Banerjee S, Hughes T, Kojetin DJ, Lundasen T, Shin Y, Liu J, Cameron MD, Noel R, Yoo SH, Takahashi JS, Butler AA, Kamenecka TM, Burris TP: Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 2012, 485:62-68.
• [89]Borbely AA, Wirz-Justice A: Sleep, sleep deprivation and depression. A hypothesis derived from a model of sleep regulation. Hum Neurobiol 1982, 1:205-210.
• [90]Adamantidis A, de Lecea L: Sleep and metabolism: shared circuits, new connections. Trends Endocrinol Metab 2008, 19:362-370.
• [91]Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, Mignot E: The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 1999, 98:365-376.
• [92]Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E: Hypocretin (orexin) deficiency in human narcolepsy. Lancet 2000, 355:39-40.
• [93]Hara J, Beuckmann CT, Nambu T, Willie JT, Chemelli RM, Sinton CM, Sugiyama F, Yagami K, Goto K, Yanagisawa M, Sakurai T: Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 2001, 30:345-354.
• [94]Roecker AJ, Coleman PJ: Orexin receptor antagonists: medicinal chemistry and therapeutic potential. Curr Top Med Chem 2008, 8:977-987.
• [95]Coleman PJ, Renger JJ: Orexin receptor antagonists: a review of promising compounds patented since 2006. Expert Opin Ther Pat 2010, 20:307-324.
• [96]Coleman PJ, Cox CD, Roecker AJ: Discovery of dual orexin receptor antagonists (DORAs) for the treatment of insomnia. Curr Top Med Chem 2011, 11:696-725.
• [97]Salomon RM, Ripley B, Kennedy JS, Johnson B, Schmidt D, Zeitzer JM, Nishino S, Mignot E: Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjects. Biol Psychiatry 2003, 54:96-104.
• [98]Hirayama J, Sahar S, Grimaldi B, Tamaru T, Takamatsu K, Nakahata Y, Sassone-Corsi P: CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature 2007, 450:1086-1090.
• [99]Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, Maywood ES, Hastings MH, Baliga NS, Merrow M, Millar AJ, Johnson CH, Kyriacou CP, O’Neill JS, Reddy AB: Peroxiredoxins are conserved markers of circadian rhythms. Nature 2012, 485:459-464.
• [100]Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, Lopez JP, Philipson LH, Bradfield CA, Crosby SD, JeBailey L, Wang X, Takahashi JS, Bass J: Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature 2010, 466:627-631.
• [101]Turek FW: Circadian clocks: tips from the tip of the iceberg. Nature 2008, 456:881-883.
• [102]Lamia KA, Evans RM: Metabolism: tick, tock, a [beta]-cell clock. Nature 2010, 466:571-572.
• [103]Rouyer F: Circadian rhythms: no lazing on sunny afternoons. Nature 2012, 484:325-326.
• [104]Masri S, Sassone-Corsi P: Plasticity and specificity of the circadian epigenome. Nat Neurosci 2010, 13:1324-1329.
• [105]Roth TL, Sweatt JD: Rhythms of memory. Nat Neurosci 2008, 11:993-994.
• [106]Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE: Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry 2005, 62:593-602.
• [107]Avenevoli S, Merikangas KR: Implications of high-risk family studies for prevention of depression. Am J Prev Med 2006, 31:126-135.
• [108]Wright MJ, Martin NG: Brisbane adolescent twin study: outline of study methods and research projects. Aust J Psychol 2004, 56:65-78.
• [109]Hansell NK, Wright MJ, Medland SE, Davenport TA, Wray NR, Martin NG, Hickie IB: Genetic co-morbidity between neuroticism, anxiety/depression and somatic distress in a population sample of adolescent and young adult twins. Psychol Med 2012, 42:1249-1260.
• [110]Hatton SN, Lagopoulos J, Hermens DF, Naismith SL, Bennett MR, Hickie IB: Correlating anterior insula gray matter volume changes in young people with clinical and neurocognitive outcomes: an MRI study. BMC Psychiatry 2012, 12:45.
• [111]Lagopoulos J, Hermens DF, Naismith SL, Scott EM, Hickie IB: Frontal lobe changes occur early in the course of affective disorders in young people. BMC Psychiatry 2012, 12:4.
• [112]Gillespie NA, Kirk KM, Evans DM, Heath AC, Hickie IB, Martin NG: Do the genetic or environmental determinants of anxiety and depression change with age? A longitudinal study of Australian twins. Twin Res 2004, 7:39-53.
• [113]Hickie I, Scott E, Wilhelm K, Brodaty H: Subcortical hyperintensities on magnetic resonance imaging in patients with severe depression–a longitudinal evaluation. Biol Psychiatry 1997, 42:367-374.
• [114]Hickie I, Simons L, Naismith S, Simons J, McCallum J, Pearson K: Vascular risk to late-life depression: evidence from a longitudinal community study. Aust N Z J Psychiatry 2003, 37:62-65.
• [115]Hickie I, Scott E, Naismith S, Ward PB, Turner K, Parker G, Mitchell P, Wilhelm K: Late-onset depression: genetic, vascular and clinical contributions. Psychol Med 2001, 31:1403-1412.
• [116]Naismith SL, Norrie L, Lewis SJ, Rogers NL, Scott EM, Hickie IB: Does sleep disturbance mediate neuropsychological functioning in older people with depression? J Affect Disord 2009, 116:139-143.
• [117]Naismith SL, Glozier N, Burke D, Carter PE, Scott E, Hickie IB: Early intervention for cognitive decline: is there a role for multiple medical or behavioural interventions? Early Interv Psychiatry 2009, 3:19-27.
• [118]Alexopoulos GS, Schultz SK, Lebowitz BD: Late-life depression: a model for medical classification. Biol Psychiatry 2005, 58:283-289.
• [119]Krishnan KR, Hays JC, Tupler LA, George LK, Blazer DG: Clinical and phenomenological comparisons of late-onset and early-onset depression. Am J Psychiatry 1995, 152:785-788.
• [120]Naismith SL, Diamond K, Carter PE, Norrie LM, Redoblado-Hodge MA, Lewis SJ, Hickie IB: Enhancing memory in late-life depression: the effects of a combined psychoeducation and cognitive training program. Am J Geriatr Psychiatry 2010, 19:240-248.
• [121]Christensen H, Pallister E, Smale S, Hickie IB, Calear AL: Community-based prevention programs for anxiety and depression in youth: a systematic review. J Prim Prev 2010, 31:139-170.
• [122]Paus T, Keshavan M, Giedd JN: Why do many psychiatric disorders emerge during adolescence? Nat Rev Neurosci 2008, 9:947-957.
• [123]Robillard R, Naismith SL, Rogers NL, Ip TK, Hermens DF, Scott EM, Hickie IB: Delayed sleep phase in young people with unipolar or bipolar affective disorders. J Affect Disord 2013, 145:260-263.
• [124]Merikangas KR, Cui L, Kattan G, Carlson GA, Youngstrom EA, Angst J: Mania with and without depression in a community sample of U.S. adolescents. Arch Gen Psychiatry 2012, 69:943-951.
• [125]Kirk KM, Hickie IB, Martin NG: Fatigue as related to anxiety and depression in a community-based sample of twins aged over 50. Soc Psychiatry Psychiatr Epidemiol 1999, 34:85-90.
• [126]Hickie I, Kirk K, Martin N: Unique genetic and environmental determinants of prolonged fatigue: a twin study. Psychol Med 1999, 29:259-268.
• [127]Hickie I, Bennett B, Lloyd A, Heath A, Martin N: Complex genetic and environmental relationships between psychological distress, fatigue and immune functioning: a twin study. Psychol Med 1999, 29:269-277.
• [128]van der Linden G, Chalder T, Hickie I, Koschera A, Sham P, Wessely S: Fatigue and psychiatric disorder: different or the same? Psychol Med 1999, 29:863-868.
• [129]Lloyd AR, Hickie I, Peterson PK: Chronic fatigue syndrome: current concepts of pathogenesis and treatment. Curr Clin Top Infect Dis 1999, 19:135-159.
• [130]Hickie I, Koschera A, Hadzi-Pavlovic D, Bennett B, Lloyd A: The temporal stability and co-morbidity of prolonged fatigue: a longitudinal study in primary care. Psychol Med 1999, 29:855-861.
• [131]Perlis ML, Giles DE, Buysse DJ, Tu X, Kupfer DJ: Self-reported sleep disturbance as a prodromal symptom in recurrent depression. J Affect Disord 1997, 42:209-212.
• [132]Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ: The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989, 28:193-213.
• [133]Agargun MY, Besiroglu L, Cilli AS, Gulec M, Aydin A, Inci R, Selvi Y: Nightmares, suicide attempts, and melancholic features in patients with unipolar major depression. J Affect Disord 2007, 98(3):267-270.
• [134]Ohayon MM, Caulet M, Philip P, Guilleminault C, Priest RG: How sleep and mental disorders are related to complaints of daytime sleepiness. Arch Intern Med 1997, 157:2645-2652.
• [135]Dryman A, Eaton WW: Affective symptoms associated with the onset of major depression in the community: findings from the US National Institute of Mental Health Epidemiologic Catchment Area Program. Acta Psychiatr Scand 1991, 84(1):1-5.
• [136]Benca RM, Obermeyer WH, Thisted RA, Gillin JC: Sleep and psychiatric disorders. A meta-analysis. Arch Gen Psychiatry 1992, 49(8):651-668. discussion 669-670
• [137]Feinberg M, Gillin JC, Carroll BJ, Greden JF, Zis AP: EEG studies of sleep in the diagnosis of depression. Biol Psychiatry 1982, 17:305-316.
• [138]Thase ME, Kupfer DJ, Fasiczka AJ, Buysse DJ, Simons AD, Frank E: Identifying an abnormal electroencephalographic sleep profile to characterize major depressive disorder. Biol Psychiatry 1997, 41:964-973.
• [139]Kupfer DJ, Foster FG: Interval between onset of sleep and rapid-eye-movement sleep as an indicator of depression. Lancet 1972, 2:684-686.
• [140]Buysse DJ, Frank E, Lowe KK, Cherry CR, Kupfer DJ: Electroencephalographic sleep correlates of episode and vulnerability to recurrence in depression. Biol Psychiatry 1997, 41(4):406-418.
• [141]Peppard PE, Szklo-Coxe M, Hla KM, Young T: Longitudinal association of sleep-related breathing disorder and depression. Arch Intern Med 2006, 166(16):1709-1715.
• [142]Schroder CM, O'Hara R: Depression and Obstructive Sleep Apnea (OSA). Annals of general psychiatry 2005, 4:13.
• [143]Wehr TA, Wirz-Justice A, Goodwin FK, Duncan W, Gillin JC: Phase advance of the circadian sleep-wake cycle as an antidepressant. Science 1979, 206(4419):710-713.
• [144]Nair NP, Hariharasubramanian N, Pilapil C: Circadian rhythm of plasma melatonin in endogenous depression. Prog Neuropsychopharmacol Biol Psychiatry 1984, 8(4–6):715-718.
• [145]Claustrat B, Chazot G, Brun J, Jordan D, Sassolas G: A chronobiological study of melatonin and cortisol secretion in depressed subjects: plasma melatonin, a biochemical marker in major depression. Biol Psychiatry 1984, 19(8):1215-1228.
• [146]Beck-Friis J, Kjellman BF, Aperia B, Unden F, von Rosen D, Ljunggren JG, Wetterberg L: Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome. Acta Psychiatr Scand 1985, 71(4):319-330.
• [147]Souetre E, Salvati E, Belugou JL, Pringuey D, Candito M, Krebs B, Ardisson JL, Darcourt G: Circadian rhythms in depression and recovery: evidence for blunted amplitude as the main chronobiological abnormality. Psychiatry Res 1989, 28(3):263-278.
• [148]Rao AV, Devi SP, Srinivasan V: Urinary melatonin in depression. Indian journal of psychiatry 1983, 25(3):167-172.
• [149]Wetterberg L, Aperia B, Gorelick DA, Gwirtzman HE, McGuire MT, Serafetinides EA, Yuwiler A: Age, alcoholism and depression are associated with low levels of urinary melatonin. J Psychiatry Neurosci 1992, 17(5):215-224.
• [150]Peeters F, Nicolson NA, Berkhof J: Levels and variability of daily life cortisol secretion in major depression. Psychiatry Res 2004, 126(1):1-13.
• [151]Linkowski P, Mendlewicz J, Leclercq R, Brasseur M, Hubain P, Golstein J, Copinschi G, Van Cauter E: The 24-hour profile of adrenocorticotropin and cortisol in major depressive illness. J Clin Endocrinol Met 1985, 61:429-438.
• [152]Avery DH, Wildschiodtz G, Rafaelsen OJ: Nocturnal temperature in affective disorder. J Affect Disord 1982, 4(1):61-71.
• [153]Taillard J, Sanchez P, Lemoine P, Mouret J: Heart rate circadian rhythm as a biological marker of desynchronization in major depression: a methodological and preliminary report. Chronobiol Int 1990, 7(4):305-316.
• [154]Taillard J, Lemoine P, Boule P, Drogue M, Mouret J: Sleep and heart rate circadian rhythm in depression: the necessity to separate. Chronobiol Int 1993, 10(1):63-72.
• [155]Kario K, Schwartz JE, Davidson KW, Pickering TG: Gender differences in associations of diurnal blood pressure variation, awake physical activity, and sleep quality with negative affect: the work site blood pressure study. Hypertension 2001, 38(5):997-1002.
• [156]Alesci S, Martinez PE, Kelkar S, Ilias I, Ronsaville DS, Listwak SJ, Ayala AR, Licinio J, Gold HK, Kling MA, Chrousos GP, Gold PW: Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications. J Clin Endocrinol Metab 2005, 90:2522-2530.
• [157]Bridges PK, Jones MT: The diurnal rhythm of plasma cortisol concentration in depression. Br J Psychiatry 1966, 112(493):1257-1261.
• [158]Board F, Wadeson R, Persky H: Depressive affect and endocrine functions; blood levels of adrenal cortex and thyroid hormones in patients suffering from depressive reactions. AMA archives of neurology and psychiatry 1957, 78(6):612-620.
• [159]Mendlewicz J, Linkowski P, Branchey L, Weinberg U, Weitzman ED, Branchey M: Abnormal 24 hour pattern of melatonin secretion in depression. Lancet 1979, 2(8156–8157):1362.
• [160]Weeke A, Weeke J: The 24-hour pattern of serum TSH in patients with endogenous depression. Acta Psychiatr Scand 1980, 62(1):69-74.
• [161]Brown R, Kocsis JH, Caroff S, Amsterdam J, Winokur A, Stokes PE, Frazer A: Differences in nocturnal melatonin secretion between melancholic depressed patients and control subjects. Am J Psychiatry 1985, 142(7):811-816.
• [162]Crasson M, Kjiri S, Colin A, Kjiri K, L'Hermite-Baleriaux M, Ansseau M, Legros JJ: Serum melatonin and urinary 6-sulfatoxymelatonin in major depression. Psychoneuroendocrinology 2004, 29(1):1-12.
• [163]Szymanska A, Rabe-Jablonska J, Karasek M: Diurnal profile of melatonin concentrations in patients with major depression: relationship to the clinical manifestation and antidepressant treatment. Neuro Endocrinol Lett 2001, 22(3):192-198.
• [164]Rabe-Jablonska J, Szymanska A: Diurnal profile of melatonin secretion in the acute phase of major depression and in remission. Med Sci Monit 2001, 7(5):946-952.
• [165]Koenigsberg HW, Teicher MH, Mitropoulou V, Navalta C, New AS, Trestman R, Siever LJ: 24-h Monitoring of plasma norepinephrine, MHPG, cortisol, growth hormone and prolactin in depression. J Psychiatr Res 2004, 38(5):503-511.
• [166]Mendlewicz J, Linkowski P, Kerkhofs M, Desmedt D, Golstein J, Copinschi G, Van Cauter E: Diurnal hypersecretion of growth hormone in depression. J Clin Endocrinol Metabol 1985, 60(3):505-512.
• [167]Branchey L, Weinberg U, Branchey M, Linkowski P, Mendlewicz J: Simultaneous study of 24-hour patterns of melatonin and cortisol secretion in depressed patients. Neuropsychobiology 1982, 8(5):225-232.
• [168]Posener JA, DeBattista C, Williams GH, Chmura Kraemer H, Kalehzan BM, Schatzberg AF: 24-Hour monitoring of cortisol and corticotropin secretion in psychotic and nonpsychotic major depression. Arch Gen Psychiatry 2000, 57(8):755-760.
• [169]Gordijn MC, Beersma DG, Bouhuys AL, Reinink E, Van den Hoofdakker RH: A longitudinal study of diurnal mood variation in depression; characteristics and significance. J Affect Disord 1994, 31(4):261-273.
• [170]Germain A, Nofzinger EA, Meltzer CC, Wood A, Kupfer DJ, Moore RY, Buysse DJ: Diurnal variation in regional brain glucose metabolism in depression. Biol Psychiatry 2007, 62(5):438-445.
• [171]Joyce PR, Porter RJ, Mulder RT, Luty SE, McKenzie JM, Miller AL, Kennedy MA: Reversed diurnal variation in depression: associations with a differential antidepressant response, tryptophan: large neutral amino acid ratio and serotonin transporter polymorphisms. Psychol Med 2005, 35(4):511-517.
• [172]Shin K, Schaffer A, Levitt AJ, Boyle MH: Seasonality in a community sample of bipolar, unipolar and control subjects. J Affect Disord 2005, 86(1):19-25.
• [173]Hasler BP, Buysse DJ, Kupfer DJ, Germain A: Phase relationships between core body temperature, melatonin, and sleep are associated with depression severity: further evidence for circadian misalignment in non-seasonal depression. Psychiatry Res 2010, 178(1):205-207.
• [174]Puig-Antich J, Goetz R, Hanlon C, Davies M, Thompson J, Chambers WJ, Tabrizi MA, Weitzman ED: Sleep architecture and REM sleep measures in prepubertal children with major depression: a controlled study. Arch Gen Psychiatry 1982, 39:932-939.
• [175]Bertocci MA, Dahl RE, Williamson DE, Iosif AM, Birmaher B, Axelson D, Ryan ND: Subjective sleep complaints in pediatric depression: a controlled study and comparison with EEG measures of sleep and waking. J Am Acad Child Adolesc Psychiatry 2005, 44:1158-1166.
• [176]Armitage R, Hoffmann R, Emslie G, Rintelmann J, Robert J: Sleep microarchitecture in childhood and adolescent depression: temporal coherence. Clin EEG Neurosci 2006, 37(1):1-9.
• [177]Robert JJ, Hoffmann RF, Emslie GJ, Hughes C, Rintelmann J, Moore J, Armitage R: Sex and age differences in sleep macroarchitecture in childhood and adolescent depression. Sleep 2006, 29(3):351-358.
• [178]Arana-Lechuga Y, Nunez-Ortiz R, Teran-Perez G, Castillo-Montoya C, Jimenez-Anguiano A, Gonzalez-Robles RO, Castro-Roman R, Velazquez-Moctezuma J: Sleep-EEG patterns of school children suffering from symptoms of depression compared to healthy controls. World J Biol Psychiatry 2008, 9(2):115-120.
• [179]Emslie GJ, Rush AJ, Weinberg WA, Rintelmann JW, Roffwarg HP: Sleep EEG features of adolescents with major depression. Biol Psychiatry 1994, 36(9):573-581.
• [180]Goetz RR, Puig-Antich J, Ryan N, Rabinovich H, Ambrosini PJ, Nelson B, Krawiec V: Electroencephalographic sleep of adolescents with major depression and normal controls. Arch Gen Psychiatry 1987, 44(1):61-68.
• [181]Appelboom-Fondu J, Kerkhofs M, Mendlewicz J: Depression in adolescents and young adults–polysomnographic and neuroendocrine aspects. J Affect Disord 1988, 14(1):35-40.
• [182]Kutcher S, Williamson P, Marton P, Szalai J: REM latency in endogenously depressed adolescents. Br J Psychiatry 1992, 161:399-402.
• [183]Lahmeyer HW, Poznanski EO, Bellur SN: EEG sleep in depressed adolescents. Am J Psychiatry 1983, 140(9):1150-1153.
• [184]Rao U, Poland RE: Electroencephalographic sleep and hypothalamic-pituitary-adrenal changes from episode to recovery in depressed adolescents. J Child Adolesc Psychopharmacol 2008, 18(6):607-613.
• [185]Armitage R, Hoffmann R, Emslie G, Rintelman J, Moore J, Lewis K: Rest-activity cycles in childhood and adolescent depression. J Am Acad Child Adolesc Psychiatry 2004, 43(6):761-769.
• [186]Dahl RE, Ryan ND, Puig-Antich J, Nguyen NA, Al-Shabbout M, Meyer VA, Perel J: 24-hour cortisol measures in adolescents with major depression: a controlled study. Biol Psychiatry 1991, 30(1):25-36.
• [187]Goodyer IM, Herbert J, Altham PM, Pearson J, Secher SM, Shiers HM: Adrenal secretion during major depression in 8- to 16-year-olds, I. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation. Psychol Med 1996, 26(2):245-256.
• [188]Gillin JC, Duncan WC, Murphy DL, Post RM, Wehr TA, Goodwin FK, Wyatt RJ, Bunney WE Jr: Age-related changes in sleep in depressed and normal subjects. Psychiatry Res 1981, 4(1):73-78.
• [189]Tuunainen A, Kripke DF, Elliott JA, Assmus JD, Rex KM, Klauber MR, Langer RD: Depression and endogenous melatonin in postmenopausal women. J Affect Disord 2002, 69(1–3):149-158.
• [190]Hamada T, Murata T, Omori M, Takahashi T, Kosaka H, Wada Y, Yoshida H: Abnormal nocturnal blood pressure fall in senile-onset depression with subcortical silent cerebral infarction. Neuropsychobiology 2003, 47(4):187-191.
• [191]Bunney WE Jr, Murphy DL, Goodwin FK, Borge GF: The switch process from depression to mania: relationship to drugs which alter brain amines. Lancet 1970, 1:1022-1027.
• [192]Sitaram N, Gillin JC, Bunney WE Jr: The switch process in manic-depressive illness. Circadian variation in time of switch and sleep and manic ratings before and after switch. Acta Psychiatr Scand 1978, 58:267-278.
• [193]Detre T, Himmelhoch J, Swartzburg M, Anderson CM, Byck R, Kupfer DJ: Hypersomnia and manic-depressive disease. Am J Psychiatry 1972, 128:1303-1305.
• [194]Casper RC, Redmond DE Jr, Katz MM, Schaffer CB, Davis JM, Koslow SH: Somatic symptoms in primary affective disorder. Presence and relationship to the classification of depression. Arch Gen Psychiatry 1985, 42:1098-1104.
• [195]Parker G, Malhi G, Hadzi-Pavlovic D, Parker K: Sleeping in? The impact of age and depressive sub-type on hypersomnia. J Affect Disord 2006, 90(1):73-76.
• [196]Goodwin FK, Jamison KR: Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression. New York: Oxford Univeristy Press; 2007.
• [197]de Maertelaer V, Hoffman G, Lemaire M, Mendlewicz J: Sleep spindle activity changes in patients with affective disorders. Sleep 1987, 10:443-451.
• [198]Lauer CJ, Wiegand M, Krieg JC: All-night electroencephalographic sleep and cranial computed tomography in depression. A study of unipolar and bipolar patients. Eur Arch Psychiatry Clin Neurosci 1992, 242:59-68.
• [199]Thase ME, Himmelhoch JM, Mallinger AG, Jarrett DB, Kupfer DJ: Sleep EEG and DST findings in anergic bipolar depression. Am J Psychiatry 1989, 146:329-333.
• [200]Duncan WC Jr, Pettigrew KD, Gillin JC: REM architecture changes in bipolar and unipolar depression. Am J Psychiatry 1979, 136:1424-1427.
• [201]Hudson JI, Lipinski JF, Frankenburg FR, Grochocinski VJ, Kupfer DJ: Electroencephalographic sleep in mania. Arch Gen Psychiatry 1988, 45:267-273.
• [202]Hudson JI, Lipinski JF, Keck PE Jr, Aizley HG, Lukas SE, Rothschild AJ, Waternaux CM, Kupfer DJ: Polysomnographic characteristics of young manic patients. Comparison with unipolar depressed patients and normal control subjects. Arch Gen Psychiatry 1992, 49:378-383.
• [203]Kripke DF, Mullaney DJ, Atkinson M, Wolf S: Circadian rhythm disorders in manic-depressives. Biol Psychiatry 1978, 13:335-351.
• [204]Lewy AJ, Nurnberger JI Jr, Wehr TA, Pack D, Becker LE, Powell RL, Newsome DA: Supersensitivity to light: possible trait marker for manic-depressive illness. Am J Psychiatry 1985, 142:725-727.
• [205]Lewy AJ, Wehr TA, Goodwin FK, Newsome DA, Rosenthal NE: Manic-depressive patients may be supersensitive to light. Lancet 1981, 1:383-384.
• [206]Feldman-Naim S, Turner EH, Leibenluft E: Diurnal variation in the direction of mood switches in patients with rapid-cycling bipolar disorder. J Clin Psychiatry 1997, 58(2):79-84.
• [207]Souetre E, Salvati E, Wehr TA, Sack DA, Krebs B, Darcourt G: Twenty-four-hour profiles of body temperature and plasma TSH in bipolar patients during depression and during remission and in normal control subjects. Am J Psychiatry 1988, 145:1133-1137.
• [208]Thompson C, Isaacs G: Seasonal affective disorder–a British sample. Symptomatology in relation to mode of referral and diagnostic subtype. J Affect Disord 1988, 14(1):1-11.
• [209]Giglio LM, Magalhaes PV, Andersen ML, Walz JC, Jakobson L, Kapczinski F: Circadian preference in bipolar disorder. Sleep Breath 2010, 14(2):153-155.
• [210]Mansour HA, Wood J, Chowdari KV, Dayal M, Thase ME, Kupfer DJ, Monk TH, Devlin B, Nimgaonkar VL: Circadian phase variation in bipolar I disorder. Chronobiol Int 2005, 22(3):571-584.
• [211]Robillard R, Naismith SL, Rogers NL, Ip YKC, Hermens DF, Scott EM, Hickie IB: Delayed circadian rhythms in young persons with unipolar or bipolar affective disorders. Proceedings of the 24th Annual Scientific meeting of the of Australasian Sleep Association and Australasian Sleep Technologists Association: 11-13 October 2012; Darwin. Sleep and Biological Rhythms2012; 10 (Suppl. 1): 39
• [212]Saeed SA, Bruce TJ: Seasonal affective disorders. Am Fam Physician 1998, 57:1340-1346.
• [213]Rosenthal NE, Sack DA, Gillin JC, Lewy AJ, Goodwin FK, Davenport Y, Mueller PS, Newsome DA, Wehr TA: Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry 1984, 41:72-80.
• [214]Wehr TA, Giesen HA, Schulz PM, Anderson JL, Joseph-Vanderpool JR, Kelly K, Kasper S, Rosenthal NE: Contrasts between symptoms of summer depression and winter depression. J Affect Disord 1991, 23:173-183.
• [215]Avery DH, Dahl K, Savage MV, Brengelmann GL, Larsen LH, Kenny MA, Eder DN, Vitiello MV, Prinz PN: Circadian temperature and cortisol rhythms during a constant routine are phase-delayed in hypersomnic winter depression. Biol Psychiatry 1997, 41:1109-1123.
• [216]Dahl K, Avery DH, Lewy AJ, Savage MV, Brengelmann GL, Larsen LH, Vitiello MV, Prinz PN: Dim light melatonin onset and circadian temperature during a constant routine in hypersomnic winter depression. Acta Psychiatr Scand 1993, 88:60-66.
• [217]Lewy AJ, Sack RL, Singer CM, White DM: The phase shift hypothesis for bright light's therapeutic mechanism of action: theoretical considerations and experimental evidence. Psychopharmacol Bull 1987, 23:349-353.
• [218]Thompson C, Stinson D, Fernandez M, Fine J, Isaacs G: A comparison of normal, bipolar and seasonal affective disorder subjects using the Seasonal Pattern Assessment Questionnaire. J Affect Disord 1988, 14(3):257-264.
• [219]Thompson C, Stinson D, Smith A: Seasonal affective disorder and season-dependent abnormalities of melatonin suppression by light. Lancet 1990, 336:703-706.
• [220]Akiskal HS, Judd LL, Gillin JC, Lemmi H: Subthreshold depressions: clinical and polysomnographic validation of dysthymic, residual and masked forms. J Affect Disord 1997, 45:53-63.
• [221]Zhou JN, Riemersma RF, Unmehopa UA, Hoogendijk WJ, van Heerikhuize JJ, Hofman MA, Swaab DF: Alterations in arginine vasopressin neurons in the suprachiasmatic nucleus in depression. Arch Gen Psychiatry 2001, 58:655-662.
• [222]Parker G, Hadzi-Pavlovic D, Brodaty H, Boyce P, Mitchell P, Wilhelm K, Hickie I, Eyers K: Psychomotor disturbance in depression: defining the constructs. J Affect Disord 1993, 27:255-265.
• [223]Parker G, Hadzi-Pavlovic D, Boyce P, Wilhelm K, Brodaty H, Mitchell P, Hickie I, Eyers K: Classifying depression by mental state signs. Br J Psychiatry 1990, 157:55-65.
• [224]Hickie I, Mason C, Parker G: Comparative validity of two measures of psychomotor function in patients with severe depression. J Affect Disord 1996, 37:143-149.
• [225]Schrijvers D, Hulstijn W, Sabbe BG: Psychomotor symptoms in depression: a diagnostic, pathophysiological and therapeutic tool. J Affect Disord 2008, 109:1-20.
• [226]Sobin C, Sackeim HA: Psychomotor symptoms of depression. Am J Psychiatry 1997, 154:4-17.
• [227]Wulff K, Porcheret K, Cussans E, Foster RG: Sleep and circadian rhythm disturbances: multiple genes and multiple phenotypes. Curr Op Genet Dev 2009, 19:237-246.
• [228]Artioli P, Lorenzi C, Pirovano A, Serretti A, Benedetti F, Catalano M, Smeraldi E: How do genes exert their role? Period 3 gene variants and possible influences on mood disorder phenotypes. Eur Neuropsychopharmacol 2007, 17:587-594.
• [229]Kripke DF, Nievergelt CM, Joo E, Shekhtman T, Kelsoe JR: Circadian polymorphisms associated with affective disorders. J Circ Rhythms 2009, 7:2.
• [230]Severino G, Manchia M, Contu P, Squassina A, Lampus S, Ardau R, Chillotti C, Del Zompo M: Association study in a Sardinian sample between bipolar disorder and the nuclear receptor REV-ERBalpha gene, a critical component of the circadian clock system. Bipolar Disord 2009, 11:215-220.
• [231]McGrath CL, Glatt SJ, Sklar P, Le-Niculescu H, Kuczenski R, Doyle AE, Biederman J, Mick E, Faraone SV, Niculescu AB, Tsuang MT: Evidence for genetic association of RORB with bipolar disorder. BMC Psychiatry 2009, 9:70.
• [232]Nievergelt CM, Kripke DF, Barrett TB, Burg E, Remick RA, Sadovnick AD, McElroy SL, Keck PE Jr, Schork NJ, Kelsoe JR: Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 2006, 141B:234-241.
• [233]Mansour HA, Wood J, Logue T, Chowdari KV, Dayal M, Kupfer DJ, Monk TH, Devlin B, Nimgaonkar VL: Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia. Genes Brain Behav 2006, 5:150-157.
• [234]Soria V, Martinez-Amoros E, Escaramis G, Valero J, Perez-Egea R, Garcia C, Gutierrez-Zotes A, Puigdemont D, Bayes M, Crespo JM, Martorell L, Vilella E, Labad A, Vallejo J, Perez V, Menchon JM, Estivill X, Gratacos M, Urretavizcaya M: Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. Neuropsychopharmacology 2010, 35:1279-1289.
• [235]Benedetti F, Barbini B, Bernasconi A, Fulgosi MC, Dallaspezia S, Gavinelli C, Locatelli C, Lorenzi C, Pirovano A, Radaelli D: Acute antidepressant response to sleep deprivation combined with light therapy is influenced by the catechol-O-methyltransferase Val(108/158)Met polymorphism. J Affect Disord 2010, 121(1–2):68-72.
• [236]Naismith SL, Lewis SJ, Rogers NL: Sleep-wake changes and cognition in neurodegenerative disease. Prog Brain Res 2011, 190:21-52.
• [237]Valkanova V, Ebmeier KP: Vascular risk factors and depression in later life: a systematic review and meta-analysis. Biol Psychiatry 2013, 73(5):406-413.
• [238]Xekardaki A, Santos M, Hof P, Kövari E, Bouras C, Giannakopoulos P: Neuropathological substrates and structural changes in late-life depression: the impact of vascular burden. Acta Neuropathol 2012, 124(4):453-464.
• [239]Norris ER, Karen B, Correll JR, Zemanek KJ, Lerman J, Primelo RA, Kaufmann MW: A double-blind, randomized, placebo-controlled trial of adjunctive ramelteon for the treatment of insomnia and mood stability in patients with euthymic bipolar disorder. J Affect Disord 2013, 144:141-147.
• [240]Goetze U, Tolle R: Circadian rhythm of free urinary cortisol, temperature and heart rate in endogenous depressives and under antidepressant therapy. Neuropsychobiology 1987, 18:175-184.
• [241]Buhr ED, Yoo SH, Takahashi JS: Temperature as a universal resetting cue for mammalian circadian oscillators. Science 2010, 330:379-385.
• [242]Youngstedt SD, Kripke DF, Elliott JA, Klauber MR: Circadian abnormalities in older adults. J Pineal Res 2001, 31:264-272.
• [243]Cole RJ, Smith JS, Alcala YC, Elliott JA, Kripke DF: Bright-light mask treatment of delayed sleep phase syndrome. J Biol Rhythms 2002, 17:89-101.
• [244]Nagtegaal JE, Kerkhof GA, Smits MG, Swart AC, van der Meer YG: Traumatic brain injury-associated delayed sleep phase syndrome. Funct Neurol 1997, 12:345-348.
• [245]Nagtegaal JE, Kerkhof GA, Smits MG, Swart AC, van der Meer YG: Delayed sleep phase syndrome: a placebo-controlled cross-over study on the effects of melatonin administered five hours before the individual dim light melatonin onset. J Sleep Res 1998, 7:135-143.
• [246]Middleton B, Arendt J, Stone BM: Complex effects of melatonin on human circadian rhythms in constant dim light. J Biol Rhythms 1997, 12:467-477.
• [247]Middleton B, Arendt J, Stone BM: Human circadian rhythms in constant dim light (8 lux) with knowledge of clock time. J Sleep Res 1996, 5:69-76.
• [248]Carskadon MA, Acebo C, Richardson GS, Tate BA, Seifer R: An approach to studying circadian rhythms of adolescent humans. J Biol Rhythms 1997, 12:278-289.
• [249]Carskadon MA, Wolfson AR, Acebo C, Tzischinsky O, Seifer R: Adolescent sleep patterns, circadian timing, and sleepiness at a transition to early school days. Sleep 1998, 21:871-881.
• [250]Serre F, Fatseas M, Debrabant R, Alexandre JM, Auriacombe M, Swendsen J: Ecological momentary assessment in alcohol, tobacco, cannabis and opiate dependence: a comparison of feasibility and validity. Drug Alcohol Depend 2012, 126:118-123.
• [251]Granholm E, Loh C, Swendsen J: Feasibility and validity of computerized ecological momentary assessment in schizophrenia. Schizophr Bull 2008, 34:507-514.
• [252]Duffy A, Alda M, Crawford L, Milin R, Grof P: The early manifestations of bipolar disorder: a longitudinal prospective study of the offspring of bipolar parents. Bipolar Disord 2007, 9:828-838.
• [253]Gregory AM, Rijsdijk FV, Lau JY, Dahl RE, Eley TC: The direction of longitudinal associations between sleep problems and depression symptoms: a study of twins aged 8 and 10 years. Sleep 2009, 32:189-199.
• [254]Buysse DJ, Angst J, Gamma A, Ajdacic V, Eich D, Rossler W: Prevalence, course, and comorbidity of insomnia and depression in young adults. Sleep 2008, 31:473-480.
• [255]Roane BM, Taylor DJ: Adolescent insomnia as a risk factor for early adult depression and substance abuse. Sleep 2008, 31:1351-1356.
• [256]Rao U, Dahl RE, Ryan ND, Birmaher B, Williamson DE, Rao R, Kaufman J: Heterogeneity in EEG sleep findings in adolescent depression: unipolar versus bipolar clinical course. J Affect Disord 2002, 70:273-280.
• [257]Naismith SL, Rogers NL, Hickie IB, Mackenzie J, Norrie LM, Lewis SJ: Sleep well, think well: sleep-wake disturbance in mild cognitive impairment. J Geriatr Psychiatry Neurol 2010, 23:123-130.
• [258]Naismith SL, Rogers NL, Mackenzie J, Hickie IB, Lewis SJ: The relationship between actigraphically defined sleep disturbance and REM sleep behaviour disorder in parkinson's disease. Clin Neurol Neurosurg 2010, 112:420-423.
• [259]Naismith SL, Rogers NL, Lewis SJ, Diamond K, Terpening Z, Norrie L, Hickie IB: Sleep disturbance in mild cognitive impairment: differential effects of current and remitted depression. Acta Neuropsychiatrica 2011, 23:167-172.
• [260]Naismith SL, Terpening Z, Shine JM, Lewis SJ: Neuropsychological functioning in Pparkinson’s disease: differential relationships with self-reported sleep-wake disturbances. Mov Disord 2011, 26:1537-1541.
• [261]Ellis P, Royal Australian and New Zealand College of Psychiatrists Clinical Practice Guidelines Team for Depression: Australian and New Zealand clinical practice guideline for the treatment of depression. Aust NZ J Psychiatry 2004, 38:389-407.
• [262]Whitty P, Gilbody S: NICE, but will they help people with depression? The new national institute for clinical excellence depression guidelines. Br J Psychiatry 2005, 186:177-178.
• [263]Bunney BG, Bunney WE: Rapid-acting antidepressant strategies: mechanisms of action. Int J Neuropsychopharmacol 2012, 15:695-713.
• [264]Bunney JN, Potkin SG: Circadian abnormalities, molecular clock genes and chronobiological treatments in depression. Br Med Bull 2008, 86(1):23-32.
• [265]Ehlers CL, Kupfer DJ, Frank E, Monk TH: Biological rhythms and depression: the role of zeitgebers and zeitstoreres. Depression 1993, 1:285-293.
• [266]Bootzin RR: Stimulus control treatment for Insomnia. In 80th Annual Convention of the American Psychological Association. Honolulu, HI; 1972:395-396.
• [267]Spielman AJ, Saskin P, Thorpy MJ: Treatment of chronic insomnia by restriction of time in bed. Sleep 1987, 10(1):45-56.
• [268]Shoham-Salomon V, Rosenthal R: Paradoxical interventions: a meta-analysis. J Consult Clin Psychol 1987, 55(1):22-28.
• [269]Harvey AG, Payne S: The management of unwanted pre-sleep thoughts in insomnia: distraction with imagery versus general distraction. Behav Res Ther 2002, 40(3):267-277.
• [270]Buysse DJPMM: The evaluation and treatment of insomnia. Journal of Practical Psychiatry & Behavioral Health 1996, 2(2):80-93.
• [271]Wirz-Justice A, Benedetti F, Terman M: Chronotherapeutics for Affective Disorders: A Clinician’s Manual for Light and Wake Therapy. New York, NY: S Karger; 2009.
• [272]Czeisler CA, Richardson GS, Coleman RM, Zimmerman JC, Moore-Ede MC, Dement WC, Weitzman ED: Chronotherapy: resetting the circadian clocks of patients with delayed sleep phase insomnia. Sleep 1981, 4(1):1-21.
• [273]Terman M, Terman JS: Light therapy for seasonal and nonseasonal depression: efficacy, protocol, safety, and side effects. CNS Spectr 2005, 10:647-663. quiz 672
• [274]Barbini B, Benedetti F, Colombo C, Dotoli D, Bernasconi A, Cigala-Fulgosi M, Florita M, Smeraldi E: Dark therapy for mania: a pilot study. Bipolar Disord 2005, 7:98-101.
• [275]Wehr TA, Sack DA, Rosenthal NE: Antidepressant effects of sleep deprivation and phototherapy. Acta Psychiatr Belg 1985, 85(5):593-602.
• [276]Chesson AL Jr, Littner M, Davila D, Anderson WM, Grigg-Damberger M, Hartse K, Johnson S, Wise M: Practice parameters for the use of light therapy in the treatment of sleep disorders. Standards of practice committee, american academy of sleep medicine. Sleep 1999, 22(5):641-660.
• [277]Czeisler CA, Kronauer RE, Mooney JJ, Anderson JL, Allan JS: Biologic rhythm disorders, depression, and phototherapy. A new hypothesis. Psychiatr Clin North Am 1987, 10(4):687-709.
• [278]Wirz-Justice A: Beginning to see the light. Arch Gen Psychiatry 1998, 55(10):861-862.
• [279]Jindal RD, Thase ME: Treatment of insomnia associated with clinical depression. Sleep Med Rev 2004, 8:19-30.
• [280]Winokur A, Gary KA, Rodner S, Rae-Red C, Fernando AT, Szuba MP: Depression, sleep physiology, and antidepressant drugs. Depress Anxiety 2001, 14:19-28.
• [281]Wilson S, Argyropoulos S: Antidepressants and sleep: a qualitative review of the literature. Drugs 2005, 65:927-947.
• [282]Gursky JT, Krahn LE: The effects of antidepressants on sleep: a review. Harv Rev Psychiatry 2000, 8:298-306.
• [283]Wirz-Justice A, Graw P, Krauchi K, Gisin B, Arendt J, Aldhous M, Poldinger W: Morning or nighttime melatonin is ineffective in seasonal affective disorder. J Psychiatr Res 1990, 24:129-137.
• [284]Leibenluft E, Feldman-Naim S, Turner EH, Wehr TA, Rosenthal NE: Effects of exogenous melatonin administration and withdrawal in five patients with rapid-cycling bipolar disorder. J Clin Psychiatry 1997, 58:383-388.
• [285]Dolberg OT, Hirschmann S, Grunhaus L: Melatonin for the treatment of sleep disturbances in major depressive disorder. Am J Psychiatry 1998, 155:1119-1121.
• [286]Morin CM: Insomnia: Psychological Assessment and Management. New York, NY: Guilford Press; 1993.
• [287]Edinger JD, Carney CE: Overcoming Insomnia; A Cognitive-Behavioural Therapy Approach (Therapist Guide). New York, NY: Oxford University Press; 2008.
• [288]Perlis ML, Jungquist C, Smith MT, Posner D: Cognitive Behavioral Treatment of Insomnia: A Session-by-Session Guide. New York, NY: Springer; 2005.
• [289]Wirz-Justice A, Van den Hoofdakker RH: Sleep deprivation in depression: what do we know, where do we go? Biol Psychiatry 1999, 46(4):445-453.
• [290]Pflug B: The effect of sleep deprivation on depressed patients. Acta Psychiatr Scand 1976, 53(2):148-158.
• [291]Wehr TA, Rosenthal NE, Sack DA, Gillin JC: Antidepressant effects of sleep deprivation in bright and dim light. Acta Psychiatr Scand 1985, 72(2):161-165.
• [292]Harris J, Lack L, Kemp K, Wright H, Bootzin R: A randomized controlled trial of intensive sleep retraining (ISR): a brief conditioning treatment for chronic insomnia. Sleep 2012, 35:49-60.
• [293]Kahn M, Baker BL, Weiss JM: Treatment of insomnia by relaxation training. J Abnorm Psychol 1968, 73(6):556-558.
• [294]Bernstein DA, Borkovec TD: Progressive relaxation training: a manual for the helping professions. In., edn. Michigan: Research Press; 1973.
• [295]Smith J: Advances in ABC relaxation: Application and inventories. New York, NY: Springer; 2001.
• [296]Schultz JH, Luthe W: Autogenic Therapy. New York, NY: Grune and Stratton; 1969. 1
• [297]Kupfer DJ, Ehlers CL, Frank E, Grochocinski VJ, McEachran AB, Buhari A: Persistent effects of antidepressants: EEG sleep studies in depressed patients during maintenance treatment. Biol Psychiatry 1994, 35:781-793.
• [298]Ehlers CL, Havstad JW, Kupfer DJ: Estimation of the time course of slow-wave sleep over the night in depressed patients: effects of clomipramine and clinical response. Biol Psychiatry 1996, 39:171-181.
• [299]Campbell SS, Gillin JC, Kripke DF, Janowsky DS, Risch SC: Lithium delays circadian phase of temperature and REM sleep in a bipolar depressive: a case report. Psychiatry Res 1989, 27:23-29.
• [300]Benedetti F, Barbini B, Campori E, Fulgosi MC, Pontiggia A, Colombo C: Sleep phase advance and lithium to sustain the antidepressant effect of total sleep deprivation in bipolar depression: new findings supporting the internal coincidence model? J Psychiatr Res 2001, 35(6):323-329.
• [301]Abe M, Herzog ED, Block GD: Lithium lengthens the circadian period of individual suprachiasmatic nucleus neurons. Neuroreport 2000, 11(14):3261-3264.
• [302]Kaladchibachi SA, Doble B, Anthopoulos N, Woodgett JR, Manoukian AS: Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium. J Circ Rhythms 2007, 5:3.
• [303]Wilson SJ, Nutt DJ, Alford C, Argyropoulos SV, Baldwin DS, Bateson AN, Britton TC, Crowe C, Dijk DJ, Espie CA, Gringras P, Hajak G, Idzikowski C, Krystal AD, Nash JR, Selsick H, Sharpley AL, Wade AG: British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders. J Psychopharmacol 2010, 24:1577-1601.
• [304]Zhdanova IV, Wurtman RJ, Regan MM, Taylor JA, Shi JP, Leclair OU: Melatonin treatment for age-related insomnia. J Clinical Endocrinol Metab 2001, 86:4727-4730.
• [305]Leger D, Laudon M, Zisapel N: Nocturnal 6-sulfatoxymelatonin excretion in insomnia and its relation to the response to melatonin replacement therapy. Am J Med 2004, 116:91-95.
• [306]Rizvi SJ, Kennedy SH: The keys to improving depression outcomes. Eur Neuropsychopharmacol 2011, 21(Supplement 4):S694-S702.
• [307]Pjrek E, Winkler D, Konstantinidis A, Willeit M, Praschak-Rieder N, Kasper S: Agomelatine in the treatment of seasonal affective disorder. Psychopharmacology (Berl) 2007, 190:575-579.
• [308]Gorwood P: Restoring circadian rhythms: a new way to successfully manage depression. J Psychopharmacol 2010, 24:15-19.
• [309]Leproult R, Van Onderbergen A, L’Hermite-Balériaux M, Van Cauter E, Copinschi G: Phase-shifts of 24-h rhythms of hormonal release and body temperature following early evening administration of the melatonin agonist agomelatine in healthy older men. Clin Endocrinol 2005, 63:298-304.
• [310]Quera Salva MA, Vanier B, Laredo J, Hartley S, Chapotot F, Moulin C, Lofaso F, Guilleminault C: Major depressive disorder, sleep EEG and agomelatine: an open-label study. Int J Neuropsychopharmacol 2007, 10:691-696.
• [311]Lemoine P, Guilleminault C, Alvarez E: Improvement in subjective sleep in major depressive disorder with a novel antidepressant, agomelatine: randomized, double-blind comparison with venlafaxine. J Clin Psychiatry 2007, 68:1723-1732.
• [312]Miyamoto M: Pharmacology of ramelteon, a selective MT1/MT2 receptor agonist: a novel therapeutic drug for sleep disorders. CNS Neurosci Ther 2009, 15:32-51.
• [313]Rajaratnam SM, Polymeropoulos MH, Fisher DM, Roth T, Scott C, Birznieks G, Klerman EB: Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials. Lancet 2009, 373:482-491.
• [314]Nickelsen T, Samel A, Vejvoda M, Wenzel J, Smith B, Gerzer R: Chronobiotic effects of the melatonin agonist LY 156735 following a simulated 9 h time shift: results of a placebo-controlled trial. Chronobiol Int 2002, 19:915-936.
• [315]Singh SP, Singh V, Kar N: Efficacy of agomelatine in major depressive disorder: meta-analysis and appraisal. Int J Neuropsychopharmacol 2012, 13:417-428.
• [316]Barbui C, Cipriani A: Agomelatine and the brave old world of narrative-based medicine. Evid Based Ment Health 2012, 15:2-3.
• [317]Montgomery SA, Kasper S: Severe depression and antidepressants: focus on a pooled analysis of placebo-controlled studies on agomelatine. Int Clin Psychopharmacol 2007, 22:283-291.
• [318]Quera-Salva MA, Lemoine P, Guilleminault C: Impact of the novel antidepressant agomelatine on disturbed sleep-wake cycles in depressed patients. Hum Psychopharmacol 2010, 25:222-229.
• [319]Sack RL, Lewy AJ, White DM, Singer CM, Fireman MJ, Vandiver R: Morning vs evening light treatment for winter depression. Evidence that the therapeutic effects of light are mediated by circadian phase shifts. Arch Gen Psychiatry 1990, 47(4):343-351.
• [320]Wu JC, Kelsoe JR, Schachat C, Bunney BG, DeModena A, Golshan S, Gillin JC, Potkin SG, Bunney WE: Rapid and sustained antidepressant response with sleep deprivation and chronotherapy in bipolar disorder. Biol Psychiatry 2009, 66(3):298-301.
• [321]Voderholzer U, Valerius G, Schaerer L, Riemann D, Giedke H, Schwarzler F, Berger M, Wiegand M: Is the antidepressive effect of sleep deprivation stabilized by a three day phase advance of the sleep period? A pilot study. Eur Arch Psychiatry Clin Neurosci 2003, 253:68-72.
• [322]Souetre E, Salvati E, Pringuey D, Plasse Y, Savelli M, Darcourt G: Antidepressant effects of the sleep/wake cycle phase advance. Preliminary report. J Affect Disord 2006, 60:896-899.
• [323]Sprouse J, Braselton J, Reynolds L: Fluoxetine modulates the circadian biological clock via phase advances of suprachiasmatic nucleus neuronal firing. Biol Psychiatry 2006, 60:896-899.
• [324]Krauchi K, Cajochen C, Mori D, Graw P, Wirz-Justice A: Early evening melatonin and S-20098 advance circadian phase and nocturnal regulation of core body temperature. Am J Physiology 1997, 272:R1178-R1188.
• [325]McEachron DL, Kripke DF, Sharp FR, Lewy AJ, McClellan DE: Lithium effects on selected circadian rhythms in rats. Brain Res Bull 1985, 15:347-350.
• [326]Nagayama H: Chronic administration of imipramine and lithium changes the phase-angle relationship between the activity and core body temperature circadian rhythms in rats. Chronobiol Int 1996, 13:251-259.
• [327]Angst J: The bipolar spectrum. Br J Psychiatry 2007, 190:189-191.