Serum S-100β and NSE levels after off-pump versus on-pump coronary artery bypass graft surgery

BMC Cardiovascular Disorders

Zhen-Yu Wei¹  Qing-Ming Fan¹  Lei Zheng¹ 

[1] Department of Cardiovascular Surgery, Yantai Yuhuangding Hospital, No.20 Yuhuangding East Road, Yantai 264000, P.R. China

关键词: Meta-analysis;    Coronary artery bypass grafting;    Coronary heart disease;    NSE;    S-100β;   

Others  :  1219560
DOI  :  10.1186/s12872-015-0050-0

 received in 2015-01-13, accepted in 2015-06-01,  发布年份 2015

【 摘 要 】

Background

We aimed to evaluate serum levels of S-100 beta (S-100β) and neuron specific enolase (NSE) in patients with coronary heart disease (CHD) after off-pump versus on-pump coronary artery bypass graft (CABG) surgery.

Methods

The PubMed (~2013) and the Chinese Biomedical Database (CBM) (1982 ~ 2013) were searched without language restrictions. After extraction of relevant data from selected studies, meta-analyses were conducted using STATA software (Version 12.0, Stata Corporation, College Station, Texas USA). Possible sources of heterogeneity were examined through univariate and multivariate meta-regression analyses and verified by Monte Carlo Simulation.

Results

Eleven studies with a total of 411 CHD patients met the inclusion criteria. Our meta-analysis showed no significant difference in serum S-100β and NSE levels between the on-pump group and the off-pump group before surgery. In the on-pump group, there was a significant difference in serum S-100β levels of CHD patients between before and after surgery, especially within the first 24 h after surgery. Furthermore, in the on-pump group, there was a significant difference in serum NSE levels of CHD patients between before and after surgery, particularly at 0 h after surgery. In the off-pump group, there was an obvious difference in serum S-100β levels between before and after surgery, especially within 24 h after surgery. Our results also demonstrated that serum S-100β and NSE levels of CHD patients in the on-pump group were significantly higher than those of patients in the off-pump group, especially within 24 h after surgery.

Conclusions

Our findings provide empirical evidence that off-pump and on-pump CABG surgeries may increase serum S-100β and NSE levels in CHD patients, which was most prominent within 24 h after on-pump CABG surgery.

【 授权许可】

   
2015 Zheng et al.

【 图 表 】

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